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Open Access 01-12-2015 | Neuro

Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging

Authors: Hua-Feng Xiao, Zhi-Ye Chen, Xin Lou, Yu-Lin Wang, Qiu-Ping Gui, Yan Wang, Kai-Ning Shi, Zhen-Yu Zhou, Dan-Dan Zheng, Danny J. J. Wang, Lin Ma

Published in: European Radiology | Issue 12/2015

Abstract

Objectives

We hypothesized that three-dimensional pseudocontinuous arterial spin labelling (pCASL) may have similar efficacy in astrocytic tumour grading as dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI), and the grading accuracy may be further improved when combined with apparent diffusion coefficient (ADC) values.

Methods

Forty-three patients with astrocytic tumours were studied using diffusion weighted imaging (DWI), pCASL, and DSC-PWI. Histograms of ADC and normalized tumour cerebral blood flow values (nCBF on pCASL and nrCBF on DSC-PWI) were measured and analyzed.

Results

The mean 10 % ADC value was the DWI parameter that provided the best differentiation between low-grade astrocytoma (LGA) and high-grade astrocytoma (HGA). The nCBF and nrCBF (1.810 ± 0.979 and 2.070 ± 1.048) in LGA were significantly lower than those (4.505 ± 2.270 and 5.922 ± 2.630) in HGA. For differentiation between LGA and HGA, the cutoff values of 0.764 × 10^-3 mm²/s for mean 10 % ADC, 2.374 for nCBF, and 3.464 for nrCBF provided the optimal accuracy (74.4 %, 86.1 %, and 88.6 %, respectively). Combining the ADC values with nCBF or nrCBF could further improve the grading accuracy to 97.7 % or 95.3 %, respectively.

Conclusions

pCASL is an alternative to DSC-PWI for astrocytic tumour grading. The combination of DWI and contrast-free pCASL offers a valuable choice in patients with risk factors.

Key Points

• pCASL shows positive correlation with DSC-PWI in astrocytic tumour grading.

• ADC values based on ADC histograms can be an objective method.

• Combination of DWI and pCASL or DSC-PWI can improve grading accuracy.

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Title: Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging
Authors: Hua-Feng Xiao
Zhi-Ye Chen
Xin Lou
Yu-Lin Wang
Qiu-Ping Gui
Yan Wang
Kai-Ning Shi
Zhen-Yu Zhou
Dan-Dan Zheng
Danny J. J. Wang
Lin Ma
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 12/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3768-2

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Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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