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Published in: European Radiology 11/2015

01-11-2015 | Musculoskeletal

Long Term Outcomes from CT-guided Indirect Cervical Nerve Root Blocks and their relationship to the MRI findings- A prospective Study

Authors: Susanne Bensler, Reto Sutter, Christian W. A. Pfirrmann, Cynthia K. Peterson

Published in: European Radiology | Issue 11/2015

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Abstract

Purpose

To investigate long-term pain reduction and ‘improvement’ in patients with indirect cervical nerve-root-blocks in comparison to MRI findings.

Material and Methods

One hundred and twelve patients with MRI confirmed cervical radiculopathy and an indirect cervical nerve-root-block were included. Two radiologists independently evaluated the MRI examinations. 12 different MRI abnormalities at the level and side of infiltration were compared to pain relief and ‘improvement’ at 1-month, 3-months and 1-year post injection.

Results

The proportion of patients reporting clinically relevant 'improvement' was 36.7 % at 1-month, 53.9 % at 3-months and 68.1 % at 1-year. At 1-month post injection, a statistically significantly lower percentage of patients eventually requiring surgery reported improvement and lower NRS change scores compared to those who did not undergo surgery (p = 0.001). Patients with extrusion of the disc were around 4-times more likely to have surgery. At 1-year post-injection the presence of nerve-root compromise was significantly linked to treatment outcome (p = 0.011).

Conclusion

Patients with nerve root compression were more likely to report improvement at 1 year. Patients with disc extrusions have less pain relief and are 4 times more likely to go to surgery than patients with disc protrusions.

Key Points

Good long term outcomes after indirect nerve root infiltrations with non-particulate steroids.
The presence of nerve root compression was a predictive finding ofimprovement’.
Significantly less patients subsequently having surgery had lower NRS scores 1-month post injection.
There is less pain relief in patients with disc extrusions.
There are less improvement in patients with modic type I changes.
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Literature
1.
go back to reference Martin BI, Deyo RA, Mirza SK et al (2008) Expenditures and health status among adults with back and neck problems. JAMA 299:656–664CrossRefPubMed Martin BI, Deyo RA, Mirza SK et al (2008) Expenditures and health status among adults with back and neck problems. JAMA 299:656–664CrossRefPubMed
2.
go back to reference Rao R (2002) Neck pain, cervical radiculopathy, and cervical myelopathy: pathophysiology, natural history, and clinical evaluation. J Bone Joint Surg Am 84-A:1872–1881PubMed Rao R (2002) Neck pain, cervical radiculopathy, and cervical myelopathy: pathophysiology, natural history, and clinical evaluation. J Bone Joint Surg Am 84-A:1872–1881PubMed
3.
go back to reference Dreyfuss P, Baker R, Bogduk N (2006) Comparative effectiveness of cervical transforaminal injections with particulate and nonparticulate corticosteroid preparations for cervical radicular pain. Pain Med 7:237–242CrossRefPubMed Dreyfuss P, Baker R, Bogduk N (2006) Comparative effectiveness of cervical transforaminal injections with particulate and nonparticulate corticosteroid preparations for cervical radicular pain. Pain Med 7:237–242CrossRefPubMed
4.
go back to reference Wagner AL (2005) CT fluoroscopic-guided cervical nerve root blocks. AJNR Am J Neuroradiol 26:43–44PubMed Wagner AL (2005) CT fluoroscopic-guided cervical nerve root blocks. AJNR Am J Neuroradiol 26:43–44PubMed
5.
go back to reference Hodler J, Boos N, Schubert M (2013) Must we discontinue selective cervical nerve root blocks? Report of two cases and review of the literature. Eur Spine J 22(Suppl 3):S466–S470CrossRefPubMed Hodler J, Boos N, Schubert M (2013) Must we discontinue selective cervical nerve root blocks? Report of two cases and review of the literature. Eur Spine J 22(Suppl 3):S466–S470CrossRefPubMed
6.
go back to reference Scanlon GC, Moeller-Bertram T, Romanowsky SM, Wallace MS (2007) Cervical transforaminal epidural steroid injections: more dangerous than we think? Spine 32:1249–1256, Phila Pa 1976CrossRefPubMed Scanlon GC, Moeller-Bertram T, Romanowsky SM, Wallace MS (2007) Cervical transforaminal epidural steroid injections: more dangerous than we think? Spine 32:1249–1256, Phila Pa 1976CrossRefPubMed
7.
go back to reference Huntoon MA (2005) Anatomy of the cervical intervertebral foramina: vulnerable arteries and ischemic neurologic injuries after transforaminal epidural injections. Pain 117:104–111CrossRefPubMed Huntoon MA (2005) Anatomy of the cervical intervertebral foramina: vulnerable arteries and ischemic neurologic injuries after transforaminal epidural injections. Pain 117:104–111CrossRefPubMed
8.
go back to reference Baker R, Dreyfuss P, Mercer S, Bogduk N (2003) Cervical transforaminal injection of corticosteroids into a radicular artery: a possible mechanism for spinal cord injury. Pain 103:211–215CrossRefPubMed Baker R, Dreyfuss P, Mercer S, Bogduk N (2003) Cervical transforaminal injection of corticosteroids into a radicular artery: a possible mechanism for spinal cord injury. Pain 103:211–215CrossRefPubMed
9.
go back to reference Brouwers PJ, Kottink EJ, Simon MA, Prevo RL (2001) A cervical anterior spinal artery syndrome after diagnostic blockade of the right C6-nerve root. Pain 91:397–399CrossRefPubMed Brouwers PJ, Kottink EJ, Simon MA, Prevo RL (2001) A cervical anterior spinal artery syndrome after diagnostic blockade of the right C6-nerve root. Pain 91:397–399CrossRefPubMed
10.
go back to reference Rosenkranz M, Grzyska U, Niesen W et al (2004) Anterior spinal artery syndrome following periradicular cervical nerve root therapy. J Neurol 251:229–231CrossRefPubMed Rosenkranz M, Grzyska U, Niesen W et al (2004) Anterior spinal artery syndrome following periradicular cervical nerve root therapy. J Neurol 251:229–231CrossRefPubMed
11.
go back to reference Karasek M, Bogduk N (2004) Temporary neurologic deficit after cervical transforaminal injection of local anesthetic. Pain Med 5:202–205CrossRefPubMed Karasek M, Bogduk N (2004) Temporary neurologic deficit after cervical transforaminal injection of local anesthetic. Pain Med 5:202–205CrossRefPubMed
12.
go back to reference Tiso RL, Cutler T, Catania JA, Whalen K (2004) Adverse central nervous system sequelae after selective transforaminal block: the role of corticosteroids. Spine J 4:468–474CrossRefPubMed Tiso RL, Cutler T, Catania JA, Whalen K (2004) Adverse central nervous system sequelae after selective transforaminal block: the role of corticosteroids. Spine J 4:468–474CrossRefPubMed
13.
go back to reference Wallace MA, Fukui MB, Williams RL, Ku A, Baghai P (2007) Complications of cervical selective nerve root blocks performed with fluoroscopic guidance. AJR Am J Roentgenol 188:1218–1221CrossRefPubMed Wallace MA, Fukui MB, Williams RL, Ku A, Baghai P (2007) Complications of cervical selective nerve root blocks performed with fluoroscopic guidance. AJR Am J Roentgenol 188:1218–1221CrossRefPubMed
14.
go back to reference Okubadejo GO, Talcott MR, Schmidt RE et al (2008) Perils of intravascular methylprednisolone injection into the vertebral artery. An animal study. J Bone Joint Surg Am 90:1932–1938CrossRefPubMed Okubadejo GO, Talcott MR, Schmidt RE et al (2008) Perils of intravascular methylprednisolone injection into the vertebral artery. An animal study. J Bone Joint Surg Am 90:1932–1938CrossRefPubMed
15.
go back to reference Suresh S, Berman J, Connell DA (2007) Cerebellar and brainstem infarction as a complication of CT-guided transforaminal cervical nerve root block. Skeletal Radiol 36:449–452CrossRefPubMed Suresh S, Berman J, Connell DA (2007) Cerebellar and brainstem infarction as a complication of CT-guided transforaminal cervical nerve root block. Skeletal Radiol 36:449–452CrossRefPubMed
16.
go back to reference Rozin L, Rozin R, Koehler SA et al (2003) Death during transforaminal epidural steroid nerve root block (C7) due to perforation of the left vertebral artery. Am J Forensic Med Pathol 24:351–355CrossRefPubMed Rozin L, Rozin R, Koehler SA et al (2003) Death during transforaminal epidural steroid nerve root block (C7) due to perforation of the left vertebral artery. Am J Forensic Med Pathol 24:351–355CrossRefPubMed
17.
go back to reference Furman MB, Giovanniello MT, O'Brien EM (2003) Incidence of intravascular penetration in transforaminal cervical epidural steroid injections. Spine 28:21–25, Phila Pa 1976CrossRefPubMed Furman MB, Giovanniello MT, O'Brien EM (2003) Incidence of intravascular penetration in transforaminal cervical epidural steroid injections. Spine 28:21–25, Phila Pa 1976CrossRefPubMed
18.
go back to reference Sutter R, Pfirrmann CW, Zanetti M, Hodler J, Peterson CK (2011) CT-guided cervical nerve root injections: comparing the immediate post-injection anesthetic-related effects of the transforaminal injection with a new indirect technique. Skeletal Radiol 40:1603–1608CrossRefPubMed Sutter R, Pfirrmann CW, Zanetti M, Hodler J, Peterson CK (2011) CT-guided cervical nerve root injections: comparing the immediate post-injection anesthetic-related effects of the transforaminal injection with a new indirect technique. Skeletal Radiol 40:1603–1608CrossRefPubMed
19.
go back to reference Wolter T, Knoeller S, Berlis A, Hader C (2010) CT-guided cervical selective nerve root block with a dorsal approach. AJNR Am J Neuroradiol 31:1831–1836CrossRefPubMed Wolter T, Knoeller S, Berlis A, Hader C (2010) CT-guided cervical selective nerve root block with a dorsal approach. AJNR Am J Neuroradiol 31:1831–1836CrossRefPubMed
20.
go back to reference Klessinger S, Freund W, Karpel-Massler G, Halatsch ME (2014) Response to Transforaminal Injection of Steroids and Correlation to MRI Findings in Patients with Cervical Radicular Pain or Radiculopathy due to Disc Herniation or Spondylosis. Pain Med 15:929–937CrossRefPubMed Klessinger S, Freund W, Karpel-Massler G, Halatsch ME (2014) Response to Transforaminal Injection of Steroids and Correlation to MRI Findings in Patients with Cervical Radicular Pain or Radiculopathy due to Disc Herniation or Spondylosis. Pain Med 15:929–937CrossRefPubMed
21.
go back to reference Strobel K, Pfirrmann CW, Schmid M, Hodler J, Boos N, Zanetti M (2004) Cervical nerve root blocks: indications and role of MR imaging. Radiology 233:87–92CrossRefPubMed Strobel K, Pfirrmann CW, Schmid M, Hodler J, Boos N, Zanetti M (2004) Cervical nerve root blocks: indications and role of MR imaging. Radiology 233:87–92CrossRefPubMed
22.
go back to reference Butterworth JF, Strichartz GR (1990) Molecular mechanisms of local anesthesia: a review. Anesthesiology 72:711–734CrossRefPubMed Butterworth JF, Strichartz GR (1990) Molecular mechanisms of local anesthesia: a review. Anesthesiology 72:711–734CrossRefPubMed
23.
go back to reference Sato C, Sakai A, Ikeda Y, Suzuki H, Sakamoto A (2008) The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain. Anesth Analg 106:313–320, table of contentsCrossRefPubMed Sato C, Sakai A, Ikeda Y, Suzuki H, Sakamoto A (2008) The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain. Anesth Analg 106:313–320, table of contentsCrossRefPubMed
24.
go back to reference Toda S, Sakai A, Ikeda Y, Sakamoto A, Suzuki H (2011) A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain. Mol Pain 7:2PubMedCentralCrossRefPubMed Toda S, Sakai A, Ikeda Y, Sakamoto A, Suzuki H (2011) A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain. Mol Pain 7:2PubMedCentralCrossRefPubMed
25.
go back to reference Bush K, Hillier S (1996) Outcome of cervical radiculopathy treated with periradicular/epidural corticosteroid injections: a prospective study with independent clinical review. Eur Spine J 5:319–325CrossRefPubMed Bush K, Hillier S (1996) Outcome of cervical radiculopathy treated with periradicular/epidural corticosteroid injections: a prospective study with independent clinical review. Eur Spine J 5:319–325CrossRefPubMed
26.
go back to reference Desai A, Saha S, Sharma N, Huckerby L, Houghton R (2014) The short- and medium-term effectiveness of CT-guided selective cervical nerve root injection for pain and disability. Skeletal Radiol 43:973–978CrossRefPubMed Desai A, Saha S, Sharma N, Huckerby L, Houghton R (2014) The short- and medium-term effectiveness of CT-guided selective cervical nerve root injection for pain and disability. Skeletal Radiol 43:973–978CrossRefPubMed
27.
go back to reference Kolstad F, Leivseth G, Nygaard OP (2005) Transforaminal steroid injections in the treatment of cervical radiculopathy. A prospective outcome study. Acta Neurochir (Wien) 147:1065–1070, discussion 1070CrossRef Kolstad F, Leivseth G, Nygaard OP (2005) Transforaminal steroid injections in the treatment of cervical radiculopathy. A prospective outcome study. Acta Neurochir (Wien) 147:1065–1070, discussion 1070CrossRef
28.
go back to reference Kremer S, Pfirrmann CW, Hodler J, Peterson CK (2012) Imaging-guided lumbar facet injections: is there a difference in outcomes between low back pain patients who remember to return a postal questionnaire and those who do not? Insights Imaging 3:411–418PubMedCentralCrossRefPubMed Kremer S, Pfirrmann CW, Hodler J, Peterson CK (2012) Imaging-guided lumbar facet injections: is there a difference in outcomes between low back pain patients who remember to return a postal questionnaire and those who do not? Insights Imaging 3:411–418PubMedCentralCrossRefPubMed
29.
go back to reference Lechmann M, Peterson CK, Pfirrmann CW, Hodler J (2013) Lumbar nerve root injections: a prospective cohort outcomes study comparing age- and gender-matched patients who returned an outcomes-based postal questionnaire with patients who did not return the postal questionnaire. Skeletal Radiol 42:1429–1435CrossRefPubMed Lechmann M, Peterson CK, Pfirrmann CW, Hodler J (2013) Lumbar nerve root injections: a prospective cohort outcomes study comparing age- and gender-matched patients who returned an outcomes-based postal questionnaire with patients who did not return the postal questionnaire. Skeletal Radiol 42:1429–1435CrossRefPubMed
Metadata
Title
Long Term Outcomes from CT-guided Indirect Cervical Nerve Root Blocks and their relationship to the MRI findings- A prospective Study
Authors
Susanne Bensler
Reto Sutter
Christian W. A. Pfirrmann
Cynthia K. Peterson
Publication date
01-11-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 11/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3758-4

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