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01-11-2015 | Magnetic Resonance

T2 mapping of CT remodelling patterns in interstitial lung disease

Authors: Maria T. A. Buzan, Monika Eichinger, Michael Kreuter, Hans-Ulrich Kauczor, Felix J. Herth, Arne Warth, Carmen Monica Pop, Claus Peter Heussel, Julien Dinkel

Published in: European Radiology | Issue 11/2015

Abstract

Objectives

To evaluate lung T2 mapping for quantitative characterization and differentiation of ground-glass opacity (GGO), reticulation (RE) and honeycombing (HC) in usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP).

Methods

Twelve patients with stable UIP or NSIP underwent thin-section multislice CT and 1.5-T MRI of the lung. A total of 188 regions were classified at CT into normal (n = 29) and pathological areas, including GGO (n = 48), RE (n = 60) and HC (n = 51) predominant lesions. Entire lung T2 maps based on multi-echo single shot TSE sequence (TE: 20, 40, 79, 140, 179 ms) were generated from each subject with breath-holds at end-expiration and ECG-triggering.

Results

The median T2 relaxation of GGO was 67 ms (range 60-72 ms). RE predominant lesions had a median relaxation of 74 ms (range 69-79 ms), while for HC pattern this was 79 ms (range 74-89 ms). The median T2 relaxation for normal lung areas was 41 ms (ranged 38-49 ms), and showed significant difference to pathological areas (p < 0.001). A statistical difference was found between the T2 relaxation of GGO, RE and HC (p < 0.05).

Conclusions

The proposed method provides quantitative information for pattern differentiation, potentially allowing for monitoring of progression and response to treatment, in interstitial lung disease.

Key points

• Multi-echo single shot TSE sequence allows for entire lung T2 mapping.

• Lung remodelling patterns in ILD show different T2 relaxation.

• Quantitative T2 mapping may provide information for monitoring of ILD.

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Title: T2 mapping of CT remodelling patterns in interstitial lung disease
Authors: Maria T. A. Buzan
Monika Eichinger
Michael Kreuter
Hans-Ulrich Kauczor
Felix J. Herth
Arne Warth
Carmen Monica Pop
Claus Peter Heussel
Julien Dinkel
Publication date: 01-11-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 11/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3751-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

T2 mapping of CT remodelling patterns in interstitial lung disease

Abstract

Objectives

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

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