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European Radiology

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01-09-2015 | Chest

CT characteristics and pathological implications of early stage (T1N0M0) lung adenocarcinoma with pure ground-glass opacity

Authors: Xin Jin, Shao-hong Zhao, Jie Gao, Dian-jun Wang, Jian Wu, Chong-chong Wu, Rui-ping Chang, Hai-yue Ju

Published in: European Radiology | Issue 9/2015

Abstract

Objectives

To analyze the CT characteristics and pathological classification of early lung adenocarcinoma (T1N0M0) with pure ground-glass opacity (pGGO).

Methods

Ninety-four lesions with pGGO on CT in 88 patients with T1N0M0 lung adenocarcinoma were selected from January 2010 to December 2012. All lesions were confirmed by pathology. CT appearances were analyzed including lesion location, size, density, uniformity, shape, margin, tumour-lung interface, internal and surrounding malignant signs. Lesion size and density were compared using analysis of variance, lesion size also assessed using ROC curves. Gender of patients, lesion location and CT appearances were compared using χ2-test.

Results

There were no significant differences in gender, lesion location and density with histological invasiveness (P > 0.05). The ROC curve showed that the possibility of invasive lesion was 88.73 % when diameter of lesion was more than 10.5 mm. There was a significant difference between lesion uniformity and histological invasiveness (P = 0.01). There were significant differences in margin, tumour-lung interface, air bronchogram with histological invasiveness ( P = 0.02,P = 0.00,P = 0.048). The correlation index of lesion size and uniformity was r = 0.45 (P = 0.00).

Conclusions

The lesion size and uniformity, tumour-lung interface and the air bronchogram can help predict invasive extent of early stage lung adenocarcinoma with pGGO.

Key Points

• CT characteristics and pathological classification of pGGO lung adenocarcinoma smaller than 3 cm

• The optimal cut-off value for discriminating preinvasive from invasive lesions was 10.5 mm

• Uniformity was significant difference between histological subtypes and correlated with lesion size

• Tumour margin, tumour-lung interface and air bronchogram showed different between histological types

• No significant difference in gender, lesion location and density with histological subtypes

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Title: CT characteristics and pathological implications of early stage (T1N0M0) lung adenocarcinoma with pure ground-glass opacity
Authors: Xin Jin
Shao-hong Zhao
Jie Gao
Dian-jun Wang
Jian Wu
Chong-chong Wu
Rui-ping Chang
Hai-yue Ju
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 9/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3637-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

CT characteristics and pathological implications of early stage (T1N0M0) lung adenocarcinoma with pure ground-glass opacity

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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