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01-01-2015 | Chest

Computed tomographic characteristics of interval and post screen carcinomas in lung cancer screening

Authors: Ernst Th. Scholten, Nanda Horeweg, Harry J. de Koning, Rozemarijn Vliegenthart, Matthijs Oudkerk, Willem P. Th. M. Mali, Pim A. de Jong

Published in: European Radiology | Issue 1/2015

Abstract

Objectives

To analyse computed tomography (CT) findings of interval and post-screen carcinomas in lung cancer screening.

Methods

Consecutive interval and post-screen carcinomas from the Dutch–Belgium lung cancer screening trial were included. The prior screening and the diagnostic chest CT were reviewed by two experienced radiologists in consensus with knowledge of the tumour location on the diagnostic CT.

Results

Sixty-one participants (53 men) were diagnosed with an interval or post-screen carcinoma. Twenty-two (36 %) were in retrospect visible on the prior screening CT. Detection error occurred in 20 cancers and interpretation error in two cancers. Errors involved intrabronchial tumour (n = 5), bulla with wall thickening (n = 5), lymphadenopathy (n = 3), pleural effusion (n = 1) and intraparenchymal solid nodules (n = 8). These were missed because of a broad pleural attachment (n = 4), extensive reticulation surrounding a nodule (n = 1) and extensive scarring (n = 1). No definite explanation other than human error was found in two cases. None of the interval or post-screen carcinomas involved a subsolid nodule.

Conclusions

Interval or post-screen carcinomas that were visible in retrospect were mostly due to detection errors of solid nodules, bulla wall thickening or endobronchial lesions. Interval or post-screen carcinomas without explanation other than human errors are rare.

Key points

• 22 % of missed carcinomas originally presented as bulla wall thickening on CT.

• 22 % of missed carcinomas originally presented as endobronchial lesions on CT.

• All malignant endobronchial lesions presented as interval carcinomas.

• In the NELSON trial subsolid nodules were not a source of missed carcinomas.

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Title: Computed tomographic characteristics of interval and post screen carcinomas in lung cancer screening
Authors: Ernst Th. Scholten
Nanda Horeweg
Harry J. de Koning
Rozemarijn Vliegenthart
Matthijs Oudkerk
Willem P. Th. M. Mali
Pim A. de Jong
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 1/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3394-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Computed tomographic characteristics of interval and post screen carcinomas in lung cancer screening

Abstract

Objectives

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

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