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European Radiology
Published in: European Radiology 6/2014

01-06-2014 | Magnetic Resonance

MR diffusion imaging for preoperative staging of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis

Authors: Anita Andreano, Gilda Rechichi, Paola Rebora, Sandro Sironi, Maria Grazia Valsecchi, Stefania Galimberti

Published in: European Radiology | Issue 6/2014

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Abstract

Objectives

To compare the diagnostic accuracy of dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MR imaging in detecting deep myometrial invasion in endometrial cancer, using surgical-pathological staging as reference standard.

Methods

After searching a wide range of electronic databases and screening titles/abstracts, we obtained full papers for potentially eligible studies and evaluated according to predefined inclusion criteria. Quality assessment was conducted by adapting the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) checklist. From each study, we extracted information on diagnostic performance of DW and DCE sequences. After exploring heterogeneity, we adopted a bivariate generalized linear mixed model to compare the effect of the two MR sequences jointly on sensitivity and specificity.

Results

Nine studies (442 patients) were considered. Significant evidence of heterogeneity was found only for specificity, both in DW and DCE imaging (I 2  = 70.8 % and 70.6 %). Pooled sensitivity of DW and DCE was 0.86 and specificity did not significantly differ (p = 0.16) between the two sequences (DW = 0.86 and DCE = 0.82). No difference was found between 3-T and 1.5-T MR. There was no evidence of publication bias.

Conclusions

MR diagnostic accuracy in presurgical detection of deep myometrial infiltration in endometrial cancer is high. DCE and DW imaging do not differ in sensitivity and specificity.

Key Points

• Myometrial invasion is the most important morphological prognostic feature of endometrial cancer
• MR diagnostic accuracy in presurgical detection of deep myometrial infiltration is high
• MR examination including T2 and DCE imaging is considered the reference standard
• DW imaging has been increasingly employed with heterogeneous results
• This meta-analysis shows that DCE and DW do not differ in diagnostic accuracy
Appendix
Available only for authorised users
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Metadata
Title
MR diffusion imaging for preoperative staging of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis
Authors
Anita Andreano
Gilda Rechichi
Paola Rebora
Sandro Sironi
Maria Grazia Valsecchi
Stefania Galimberti
Publication date
01-06-2014
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3139-4

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