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Open Access 01-01-2013 | Musculoskeletal

Image registration improves human knee cartilage T1 mapping with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)

Authors: Esther E. Bron, Jasper van Tiel, Henk Smit, Dirk H. J. Poot, Wiro J. Niessen, Gabriel P. Krestin, Harrie Weinans, Edwin H. G. Oei, Gyula Kotek, Stefan Klein

Published in: European Radiology | Issue 1/2013

Abstract

Objectives

To evaluate the effect of automated registration in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of the knee on the occurrence of movement artefacts on the T1 map and the reproducibility of region-of-interest (ROI)-based measurements.

Methods

Eleven patients with early-stage knee osteoarthritis and ten healthy controls underwent dGEMRIC twice at 3 T. Controls underwent unenhanced imaging. ROIs were manually drawn on the femoral and tibial cartilage. T1 calculation was performed with and without registration of the T1-weighted images. Automated three-dimensional rigid registration was performed on the femur and tibia cartilage separately. Registration quality was evaluated using the square root Cramér–Rao lower bound (CRLB_σ). Additionally, the reproducibility of dGEMRIC was assessed by comparing automated registration with manual slice-matching.

Results

Automated registration of the T1-weighted images improved the T1 maps as the 90% percentile of the CRLB_σ was significantly (P < 0.05) reduced with a median reduction of 55.8 ms (patients) and 112.9 ms (controls). Manual matching and automated registration of the re-imaged T1 map gave comparable intraclass correlation coefficients of respectively 0.89/0.90 (patients) and 0.85/0.85 (controls).

Conclusions

Registration in dGEMRIC reduces movement artefacts on T1 maps and provides a good alternative to manual slice-matching in longitudinal studies.

Key Points

• Quantitative MRI is increasingly used for biomedical assessment of knee articular cartilage

• Image registration leads to more accurate quantification of cartilage quality and damage

• Movement artefacts in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) are reduced

• Automated image registration successfully aligns baseline and follow-up dGEMRIC examinations

• Reproducibility of dGEMRIC with registration is similar to that using manual slice-matching

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Title: Image registration improves human knee cartilage T1 mapping with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)
Authors: Esther E. Bron
Jasper van Tiel
Henk Smit
Dirk H. J. Poot
Wiro J. Niessen
Gabriel P. Krestin
Harrie Weinans
Edwin H. G. Oei
Gyula Kotek
Stefan Klein
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: European Radiology / Issue 1/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2590-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Image registration improves human knee cartilage T1 mapping with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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