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01-01-2013 | Gastrointestinal

Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case–control study

Authors: Utaroh Motosugi, Tomoaki Ichikawa, Tsuyota Koshiishi, Katsuhiro Sano, Hiroyuki Morisaka, Shintaro Ichikawa, Nobuyuki Enomoto, Masanori Matsuda, Hideki Fujii, Tsutomu Araki

Published in: European Radiology | Issue 1/2013

Abstract

Objective

To examine if liver stiffness measured by magnetic resonance elastography (MRE) is a risk factor for hepatocellular carcinoma (HCC) in patients with chronic liver disease.

Methods

By reviewing the records of magnetic resonance (MR) examinations performed at our institution, we selected 301 patients with chronic liver disease who did not have a previous medical history of HCC. All patients underwent MRE and gadoxetic acid-enhanced MR imaging. HCC was identified on MR images in 66 of the 301 patients, who were matched to controls from the remaining patients without HCC according to age. MRE images were obtained by visualising elastic waves generated in the liver by pneumatic vibration transferred via a cylindrical passive driver. Risk factors of HCC development were determined by the odds ratio with logistic regression analysis; gender and liver stiffness by MRE and serum levels of aspartate transferase, alanine transferase, alpha-fetoprotein, and protein induced by vitamin K absence-II.

Results

Multivariate analysis revealed that only liver stiffness by MRE was a significant risk factor for HCC with an odds ratio (95 % confidence interval) of 1.38 (1.05–1.84).

Conclusion

Liver stiffness measured by MRE is an independent risk factor for HCC in patients with chronic liver disease.

Key Points

• Magnetic resonance elastography can estimate liver stiffness, a marker of hepatic fibrosis.

• Liver stiffness is an independent risk factor of hepatocellular carcinoma (HCC).

• Liver stiffness seems a better indicator of HCC than tumour markers.

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Title: Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case–control study
Authors: Utaroh Motosugi
Tomoaki Ichikawa
Tsuyota Koshiishi
Katsuhiro Sano
Hiroyuki Morisaka
Shintaro Ichikawa
Nobuyuki Enomoto
Masanori Matsuda
Hideki Fujii
Tsutomu Araki
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: European Radiology / Issue 1/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2571-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case–control study

Abstract

Objective

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Key Points

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