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European Radiology

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Open Access 01-10-2012 | Contrast Media

MR liver imaging with Gd-EOB-DTPA: a delay time of 10 minutes is sufficient for lesion characterisation

Authors: C. S. van Kessel, W. B. Veldhuis, M. A. A. J. van den Bosch, M. S. van Leeuwen

Published in: European Radiology | Issue 10/2012

Abstract

Objectives

To assess whether, in patients with normal liver function, a hepatobiliary delay time of 10 min after Gd-EOB-DTPA injection is sufficient for lesion characterisation.

Methods

In 42 consecutive patients with suspected focal liver lesions, dynamic MRI was performed after intravenous Gd-EOB-DTPA, followed by hepatobiliary phases at 5, 10 and 20 min. The following items were assessed at each hepatobiliary phase: parenchymal enhancement, contrast agent excretion in bile ducts, lesion enhancement characteristics (hypo-, iso-, or hyperintensity, rim enhancement, central non-enhancement), and contrast- and signal-to-noise ratios, separately for hypo- and hyperintense lesions.

Results

Following enhancement, parenchymal signal intensity increased significantly up to 10 min (86.3%, P < 0.001), and subsequently stabilised (86.5% after 20 min, P = 0.223). Biliary contrast agent excretion was first observed in 2, 32 and 5 patients after 5, 10 and 20 min respectively. Hepatobiliary lesion enhancement characteristics observed after 5 min persisted during later hepatobiliary phases. CNR and SNR ratios increased significantly (P < 0.05) up to 10 min after enhancement without further increase at 20 min, in hypo- and hyperintense lesions.

Conclusions

If lesion characterisation is the primary reason for performing MRI, a hepatobiliary delay time of 10 min after Gd-EOB-DTPA injection is sufficient in patients with normal liver function.

Key Points

• Magnetic resonance imaging is now a first line of investigation of the liver.

• Optimal CNR and SNR are achieved 10 min after Gd-EOB-DTPA injection.

• Typical enhancement characteristics are observed early and do not change.

• Ten-minute hepatobiliary delay is sufficient for characterisation of focal liver lesions.

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Title: MR liver imaging with Gd-EOB-DTPA: a delay time of 10 minutes is sufficient for lesion characterisation
Authors: C. S. van Kessel
W. B. Veldhuis
M. A. A. J. van den Bosch
M. S. van Leeuwen
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: European Radiology / Issue 10/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2486-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

MR liver imaging with Gd-EOB-DTPA: a delay time of 10 minutes is sufficient for lesion characterisation

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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