Skip to main content
Top
Published in: European Radiology 9/2012

01-09-2012 | Chest

Analysis of the impact of digital tomosynthesis on the radiological investigation of patients with suspected pulmonary lesions on chest radiography

Authors: Emilio Quaia, Elisa Baratella, Stefano Cernic, Arianna Lorusso, Federica Casagrande, Vincenzo Cioffi, Maria Assunta Cova

Published in: European Radiology | Issue 9/2012

Login to get access

Abstract

Objective

To assess the impact of digital tomosynthesis (DTS) on the radiological investigation of patients with suspected pulmonary lesions on chest radiography (CXR).

Methods

Three hundred thirty-nine patients (200 male; age, 71.19 ± 11.9 years) with suspected pulmonary lesion(s) on CXR underwent DTS. Two readers prospectively analysed CXR and DTS images, and recorded their diagnostic confidence: 1 or 2 = definite or probable benign lesion or pseudolesion deserving no further diagnostic workup; 3 = indeterminate; 4 or 5 = probable or definite pulmonary lesion deserving further diagnostic workup by computed tomography (CT). Imaging follow-up by CT (n = 76 patients), CXR (n = 256) or histology (n = 7) was the reference standard.

Results

DTS resolved doubtful CXR findings in 256/339 (76 %) patients, while 83/339 (24 %) patients proceeded to CT. The mean interpretation time for DTS (mean ± SD, 220 ± 40 s) was higher (P < 0.05; Wilcoxon test) than for CXR (110 ± 30 s), but lower than CT (600 ± 150 s). Mean effective dose was 0.06 mSv (range 0.03–0.1 mSv) for CXR, 0.107 mSv (range 0.094–0.12 mSv) for DTS, and 3 mSv (range 2–4 mSv) for CT.

Conclusions

DTS avoided the need for CT in about three-quarters of patients with a slight increase in the interpretation time and effective dose compared to CXR.

Key Points

Digital tomosynthesis (DTS) improves the diagnostic confidence of chest radiography (CXR)
DTS reduces the need for CT for a suspected pulmonary lesion
DTS only imparts a radiation dose of around two CXRs
DTS takes longer to interpret than conventional chest radiography
Literature
1.
go back to reference Wu N, Gamsu G, Czum J et al (2006) Detection of small pulmonary nodules using direct digital radiography and picture archiving and communication systems. J Thorac Imaging 21:27–31PubMedCrossRef Wu N, Gamsu G, Czum J et al (2006) Detection of small pulmonary nodules using direct digital radiography and picture archiving and communication systems. J Thorac Imaging 21:27–31PubMedCrossRef
2.
go back to reference Bley TA, Baumann T, Saueressig U et al (2008) Comparison of radiologist and CAD performance in the detection of CT-confirmed subtle pulmonary nodules on digital chest radiographs. Investig Radiol 43:343–348CrossRef Bley TA, Baumann T, Saueressig U et al (2008) Comparison of radiologist and CAD performance in the detection of CT-confirmed subtle pulmonary nodules on digital chest radiographs. Investig Radiol 43:343–348CrossRef
3.
go back to reference Remy-Jardin M, Remy J, Giraud F, Marquette CH (1993) Pulmonary nodules: detection with thick-section spiral CT versus conventional CT. Radiology 187:513–520PubMed Remy-Jardin M, Remy J, Giraud F, Marquette CH (1993) Pulmonary nodules: detection with thick-section spiral CT versus conventional CT. Radiology 187:513–520PubMed
4.
go back to reference Rubin GD, Lyo JK, Paik DS et al (2005) Pulmonary nodules on multi-detector row CT scans: performance comparison of radiologists and computer-aided detection. Radiology 234:274–283PubMedCrossRef Rubin GD, Lyo JK, Paik DS et al (2005) Pulmonary nodules on multi-detector row CT scans: performance comparison of radiologists and computer-aided detection. Radiology 234:274–283PubMedCrossRef
5.
go back to reference Dobbins JT III, Godfrey DJ (2003) Digital x-ray tomosynthesis: current state of the art and clinical potential. Phys Med Biol 48:R65–R106PubMedCrossRef Dobbins JT III, Godfrey DJ (2003) Digital x-ray tomosynthesis: current state of the art and clinical potential. Phys Med Biol 48:R65–R106PubMedCrossRef
6.
go back to reference Dobbins JT, Mc Adams HP, Devon G, Li CM (2008) Digital tomosynthesis of the chest. J Thorac Imaging 23:86–92PubMedCrossRef Dobbins JT, Mc Adams HP, Devon G, Li CM (2008) Digital tomosynthesis of the chest. J Thorac Imaging 23:86–92PubMedCrossRef
7.
go back to reference Dobbins JT, Mc Adams HP, Song JW et al (2008) Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial. Med Phys 35:2554–2557CrossRef Dobbins JT, Mc Adams HP, Song JW et al (2008) Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial. Med Phys 35:2554–2557CrossRef
8.
go back to reference Vikgren J, Zachrisson S, Svalkvist A et al (2008) Comparison of chest tomosynthesis and chest radiography for detection of pulmonary nodules: human observer study of clinical cases. Radiology 249:1034–1041PubMedCrossRef Vikgren J, Zachrisson S, Svalkvist A et al (2008) Comparison of chest tomosynthesis and chest radiography for detection of pulmonary nodules: human observer study of clinical cases. Radiology 249:1034–1041PubMedCrossRef
9.
go back to reference Gomi T, Nakajima M, Fujiwara H, Umeda T (2011) Comparison of chest dual-energy subtraction digital tomosynthesis imaging and dual-energy subtraction radiography to detect simulated pulmonary nodules with and without calcifications a phantom study. Acad Radiol 18:191–196PubMedCrossRef Gomi T, Nakajima M, Fujiwara H, Umeda T (2011) Comparison of chest dual-energy subtraction digital tomosynthesis imaging and dual-energy subtraction radiography to detect simulated pulmonary nodules with and without calcifications a phantom study. Acad Radiol 18:191–196PubMedCrossRef
10.
go back to reference Yamada Y, Jinzaki M, Hasegawa I et al (2011) Fast scanning tomosynthesis for the detection of pulmonary nodules: diagnostic performance compared with chest radiography using multidetector-row computed tomography as the reference. Investig Radiol 46:471–477CrossRef Yamada Y, Jinzaki M, Hasegawa I et al (2011) Fast scanning tomosynthesis for the detection of pulmonary nodules: diagnostic performance compared with chest radiography using multidetector-row computed tomography as the reference. Investig Radiol 46:471–477CrossRef
11.
go back to reference Quaia E, Baratella E, Cioffi V, Bregant P, Cernic S, Cuttin R, Cova MA (2010) The value of digital tomosynthesis in the diagnosis of suspected pulmonary lesions on chest radiography: analysis of diagnostic accuracy and confidence. Acad Radiol 17:1267–1274PubMedCrossRef Quaia E, Baratella E, Cioffi V, Bregant P, Cernic S, Cuttin R, Cova MA (2010) The value of digital tomosynthesis in the diagnosis of suspected pulmonary lesions on chest radiography: analysis of diagnostic accuracy and confidence. Acad Radiol 17:1267–1274PubMedCrossRef
12.
go back to reference Kim EY, Chung MJ, Lee HY, Koh WJ, Jung HN, Lee KS (2010) Pulmonary mycobacterial disease: diagnostic performance of low-dose digital tomosynthesis as compared with chest radiography. Radiology 257:269–277PubMedCrossRef Kim EY, Chung MJ, Lee HY, Koh WJ, Jung HN, Lee KS (2010) Pulmonary mycobacterial disease: diagnostic performance of low-dose digital tomosynthesis as compared with chest radiography. Radiology 257:269–277PubMedCrossRef
13.
go back to reference Hansell DM, Bankier A, Mac Mahon H, McLoud T, Muller NL, Remy J (2008) Fleischner society: glossary of terms for thoracic imaging. Radiology 246:697–722PubMedCrossRef Hansell DM, Bankier A, Mac Mahon H, McLoud T, Muller NL, Remy J (2008) Fleischner society: glossary of terms for thoracic imaging. Radiology 246:697–722PubMedCrossRef
14.
go back to reference Servomaa A, Tapiovaara M (1998) Organ dose calculation in medical X ray examinations by the program PCXMC. Radiat Prot Dosim 80:213–219CrossRef Servomaa A, Tapiovaara M (1998) Organ dose calculation in medical X ray examinations by the program PCXMC. Radiat Prot Dosim 80:213–219CrossRef
15.
go back to reference Cristy M, Eckerman KR (1987) Specific absorbed fractions of energy at various ages from internal photon sources. I. Method. Publication no. ORNL/TM-8381, Oak Ridge National Laboratory, Oak Ridge (USA) Cristy M, Eckerman KR (1987) Specific absorbed fractions of energy at various ages from internal photon sources. I. Method. Publication no. ORNL/TM-8381, Oak Ridge National Laboratory, Oak Ridge (USA)
16.
go back to reference Sabol JM (2009) A Monte Carlo estimation of effective dose in chest tomosynthesis. Med Phys 36:5480–5487PubMedCrossRef Sabol JM (2009) A Monte Carlo estimation of effective dose in chest tomosynthesis. Med Phys 36:5480–5487PubMedCrossRef
18.
go back to reference Campbell MJ, Machin D (1999) Medical statistics, a commonsense approach. Wiley, Chichester, pp 85–89 Campbell MJ, Machin D (1999) Medical statistics, a commonsense approach. Wiley, Chichester, pp 85–89
19.
go back to reference Beck JR, Shultz EK (1986) The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 110:13–20PubMed Beck JR, Shultz EK (1986) The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 110:13–20PubMed
20.
go back to reference Hanley JA, McNeil BJ (1983) A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 148:839–843PubMed Hanley JA, McNeil BJ (1983) A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 148:839–843PubMed
21.
22.
go back to reference Erasmus JJ, Connolly JE, McAdams HP, Roggli VL (2000) Solitary pulmonary nodules. I. Morphologic evaluation for differentiation of benign and malignant lesions. RadioGraphics 20:43–58PubMed Erasmus JJ, Connolly JE, McAdams HP, Roggli VL (2000) Solitary pulmonary nodules. I. Morphologic evaluation for differentiation of benign and malignant lesions. RadioGraphics 20:43–58PubMed
23.
go back to reference Zhu X, Yu J, Huang Z (2004) Low-dose chest CT: optimizing radiation protection for patients. AJR Am J Roentgenol 183:809–816PubMed Zhu X, Yu J, Huang Z (2004) Low-dose chest CT: optimizing radiation protection for patients. AJR Am J Roentgenol 183:809–816PubMed
24.
go back to reference Gierada DS, Pilgram TK, Ford M et al (2008) Lung cancer: interobserver agreement on interpretation of pulmonary findings at low-dose CT screening. Radiology 246:265–272PubMedCrossRef Gierada DS, Pilgram TK, Ford M et al (2008) Lung cancer: interobserver agreement on interpretation of pulmonary findings at low-dose CT screening. Radiology 246:265–272PubMedCrossRef
25.
go back to reference Li B, Avinash GB (2007) Optimization of slice sensitivity profile for radiographic tomosynthesis. Med Phys 34:2907–2916PubMedCrossRef Li B, Avinash GB (2007) Optimization of slice sensitivity profile for radiographic tomosynthesis. Med Phys 34:2907–2916PubMedCrossRef
26.
go back to reference Godfrey DJ, McAdams HP, Dobbins JT (2006) Optimization of the matrix inversion tomosynthesis (MITS) impulse response and modulation transfer function characteristics for chest imaging. Med Phys 33:655–667PubMedCrossRef Godfrey DJ, McAdams HP, Dobbins JT (2006) Optimization of the matrix inversion tomosynthesis (MITS) impulse response and modulation transfer function characteristics for chest imaging. Med Phys 33:655–667PubMedCrossRef
Metadata
Title
Analysis of the impact of digital tomosynthesis on the radiological investigation of patients with suspected pulmonary lesions on chest radiography
Authors
Emilio Quaia
Elisa Baratella
Stefano Cernic
Arianna Lorusso
Federica Casagrande
Vincenzo Cioffi
Maria Assunta Cova
Publication date
01-09-2012
Publisher
Springer-Verlag
Published in
European Radiology / Issue 9/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2440-3

Other articles of this Issue 9/2012

European Radiology 9/2012 Go to the issue