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01-08-2012 | Gastrointestinal

Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer

Authors: Joon Seok Lim, Daehong Kim, Song-Ee Baek, Sungmin Myoung, Junjeong Choi, Sang Joon Shin, Myeong-Jin Kim, Nam Kyu Kim, Jinsuk Suh, Ki Whang Kim, Ki Chang Keum

Published in: European Radiology | Issue 8/2012

Abstract

Objectives

To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer.

Methods

Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRT were prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The K ^trans (volume transfer constant) and V _e (extracellular extravascular space fraction) were calculated.

Results

Before CRT, the mean tumour K ^trans in the downstaged group was significantly higher than that in the non-downstaged group (P = 0.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (P = 0.1392). Repeated-measures analysis of variance (ANOVA) showed significant differences for evolution of K ^trans values both between downstaged and non-downstaged groups (P = 0.0215) and between TRG responders and TRG non-responders (P = 0.0001). Regarding V _e, no significant differences were observed both between downstaged and non-downstaged groups (P = 0.689) or between TRG responders and TRG non-responders (P = 0.887).

Conclusion

Perfusion MRI of rectal cancer can be useful for assessing tumoural K ^trans changes by CRT. Tumours with high pre-CRT K ^trans values tended to respond favourably to CRT, particularly in terms of downstaging criteria.

Key Points

• Perfusion MRI can now assess therapeutic response of tumours to therapy.

• Tumours with high initial K ^trans values responded favourably to chemoradiotherapy.

• Perfusion MRI of rectal cancer may help with decisions about management.

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Title: Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer
Authors: Joon Seok Lim
Daehong Kim
Song-Ee Baek
Sungmin Myoung
Junjeong Choi
Sang Joon Shin
Myeong-Jin Kim
Nam Kyu Kim
Jinsuk Suh
Ki Whang Kim
Ki Chang Keum
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: European Radiology / Issue 8/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2416-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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