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01-10-2011 | Magnetic REsonance

Diagnostic performance of diffusion-weighted magnetic resonance imaging in bladder cancer: potential utility of apparent diffusion coefficient values as a biomarker to predict clinical aggressiveness

Authors: Shuichiro Kobayashi, Fumitaka Koga, Soichiro Yoshida, Hitoshi Masuda, Chikako Ishii, Hiroshi Tanaka, Yoshinobu Komai, Minato Yokoyama, Kazutaka Saito, Yasuhisa Fujii, Satoru Kawakami, Kazunori Kihara

Published in: European Radiology | Issue 10/2011

Abstract

Objectives

The diagnostic performance of diffusion-weighted magnetic resonance imaging (DW-MRI) in bladder cancer and the potential role of apparent diffusion coefficient (ADC) values in predicting pathological bladder cancer phenotypes associated with clinical aggressiveness were investigated.

Methods

One hundred and four bladder cancer patients underwent DW-MRI and T2-weighted magnetic resonance imaging (T2W-MRI) before transurethral resection. The image sets were reviewed by two independent radiologists. ADC values were measured in 121 eligible tumours.

Results

In detecting patients with bladder cancer, DW-MRI exhibited high sensitivity equivalent to that of T2W-MRI (>90%). Interobserver agreement was excellent for DW-MRI (κ score, 0.88) though moderate for T2W-MRI (0.67). ADC values were significantly lower in high-grade (vs. low-grade, P < 0.0001) and high-stage (T2 vs. T1 vs. Ta, P < 0.0001) tumours. At a cut-off ADC value determined by partition analysis, clinically aggressive phenotypes including muscle-invasive bladder cancer (MIBC) and high-grade T1 disease were differentiated from less aggressive phenotypes with a sensitivity of 88%, a specificity of 85% and an accuracy of 87%.

Conclusion

DW-MRI exhibits high diagnostic performance in bladder cancer with excellent objectivity. The ADC value could potentially serve as a biomarker to predict clinical aggressiveness in bladder cancer.

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Title: Diagnostic performance of diffusion-weighted magnetic resonance imaging in bladder cancer: potential utility of apparent diffusion coefficient values as a biomarker to predict clinical aggressiveness
Authors: Shuichiro Kobayashi
Fumitaka Koga
Soichiro Yoshida
Hitoshi Masuda
Chikako Ishii
Hiroshi Tanaka
Yoshinobu Komai
Minato Yokoyama
Kazutaka Saito
Yasuhisa Fujii
Satoru Kawakami
Kazunori Kihara
Publication date: 01-10-2011
Publisher: Springer-Verlag
Published in: European Radiology / Issue 10/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2174-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diagnostic performance of diffusion-weighted magnetic resonance imaging in bladder cancer: potential utility of apparent diffusion coefficient values as a biomarker to predict clinical aggressiveness

Abstract

Objectives

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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