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European Radiology
Published in: European Radiology 9/2011

01-09-2011 | Magnetic Resonance

Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: preliminary results

Authors: Oguz Akin, David H. Gultekin, Hebert Alberto Vargas, Junting Zheng, Chaya Moskowitz, Xin Pei, Dahlia Sperling, Lawrence H. Schwartz, Hedvig Hricak, Michael J. Zelefsky

Published in: European Radiology | Issue 9/2011

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Abstract

Objectives

To assess the incremental value of diffusion-weighted (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) to T2-weighted MRI (T2WI) in detecting locally recurrent prostate cancer after radiotherapy.

Methods

Twenty-four patients (median age, 70 years) with a history of radiotherapy-treated prostate cancer underwent multi-parametric MRI (MP-MRI) and transrectal prostate biopsy. Two readers independently scored the likelihood of cancer on a 1–5 scale, using T2WI alone and then adding DW-MRI and DCE-MRI. Areas under receiver operating characteristic curves (AUCs) were estimated at the patient and prostate-side levels. The apparent diffusion coefficient (ADC) from DW-MRI and the Ktrans, kep, ve, AUGC90 and AUGC180 from DCE-MRI were recorded.

Results

Biopsy was positive in 16/24 (67%) and negative in 8/24 (33%) patients. AUCs for readers 1 and 2 increased from 0.64 and 0.53 to 0.95 and 0.86 with MP-MRI, at the patient level, and from 0.73 and 0.66 to 0.90 and 0.79 with MP-MRI, at the prostate-side level (p values < 0.05). Biopsy-positive and biopsy-negative prostate sides differed significantly in median ADC [1.44 vs. 1.68 (×10−3 mm2/s)], median Ktrans [1.07 vs. 0.34 (1/min)], and kep [2.06 vs 1.0 (1/min)] (p values < 0.05).

Conclusions

MP-MRI was significantly more accurate than T2WI alone in detecting locally recurrent prostate cancer after radiotherapy.
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Metadata
Title
Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: preliminary results
Authors
Oguz Akin
David H. Gultekin
Hebert Alberto Vargas
Junting Zheng
Chaya Moskowitz
Xin Pei
Dahlia Sperling
Lawrence H. Schwartz
Hedvig Hricak
Michael J. Zelefsky
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 9/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-011-2130-6

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