Published in:
Open Access
01-07-2011 | Musculoskeletal
Predictive factors for new onset or progression of knee osteoarthritis one year after trauma: MRI follow-up in general practice
Authors:
Ingrid M. Koster, Edwin H. G. Oei, Jan-Hein J. Hensen, Simone S. Boks, Bart W. Koes, Dammis Vroegindeweij, M. G. Myriam Hunink, Sita M. A. Bierma-Zeinstra
Published in:
European Radiology
|
Issue 7/2011
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Abstract
Objective
To prospectively evaluate prognostic factors for new onset or progression of degenerative change on follow-up MRI one year after knee trauma and the association with clinical outcome.
Methods
Within a prospective observational cohort study in general practice, we studied a subgroup of 117 patients with acute knee trauma (mean age 41 years, 43% women). Degenerative change was scored on MRI at baseline and after one year follow-up. Multivariate logistic regression analysis was performed to evaluate prognostic factors for new onset or progressive degenerative change on follow-up MRI. Association between new or progressive degeneration and clinical outcome after one year was assessed.
Results
On follow-up MRI 15% of patients with pre-existing knee osteoarthritis showed progression and 26% of patients demonstrated new degenerative change. The only statistically significant prognostic variable in the multivariate analysis was bone marrow oedema on initial MRI (OR 5.29 (95% CI 1.64–17.1), p = 0.005). A significant association between new or progressive degenerative change and clinical outcome was found (p = 0.003).
Conclusion
Bone marrow oedema on MRI for acute knee injury is strongly predictive of new onset or progression of degenerative change of the femorotibial joint on follow-up MRI one year after trauma, which is reflected in clinical outcome.