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Open Access 01-05-2011 | Computed Tomography

The association of incidentally detected heart valve calcification with future cardiovascular events

Authors: Martijn J. A. Gondrie, Yolanda van der Graaf, Peter C. Jacobs, Ay L. Oen, Willem P. Th. M. Mali, On behalf of the PROVIDI Study Group

Published in: European Radiology | Issue 5/2011

Abstract

Objectives

This study aims to investigate the prognostic value of incidental aortic valve calcification (AVC), mitral valve calcification (MVC) and mitral annular calcification (MAC) for cardiovascular events and non-rheumatic valve disease in particular on routine diagnostic chest CT.

Methods

The study followed a case-cohort design. 10410 patients undergoing chest CT were followed for a median period of 17 months. Patients referred for cardiovascular disease were excluded. A random sample of 1285 subjects and the subjects who experienced an endpoint were graded for valve calcification by three reviewers. Cox-proportional hazard analysis was performed to evaluate the prognostic value.

Results

515 cardiovascular events were ascertained. Compared with patients with no valve calcification, patients with severe AVC, MVC or MAC had respectively 2.03 (1.48–2.78), 2.08 (1.04–4.19) and 1.53 (1.13–2.08) increased risks of experiencing an event during follow-up. For valve endpoints the hazard ratios were respectively 14.57 (5.19–40.53), 8.78 (2.33–33.13) and 2.43 (1.18–4.98).

Conclusion

Incidental heart valve calcification, detected on routine chest CT is an independent predictor of future cardiovascular events. The study emphasises how incidental imaging findings can contribute to clinical care. It is a step in the process of composing an evidence-based approach in the reporting of incidental subclinical findings.

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Title: The association of incidentally detected heart valve calcification with future cardiovascular events
Authors: Martijn J. A. Gondrie
Yolanda van der Graaf
Peter C. Jacobs
Ay L. Oen
Willem P. Th. M. Mali
On behalf of the PROVIDI Study Group
Publication date: 01-05-2011
Publisher: Springer-Verlag
Published in: European Radiology / Issue 5/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1995-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The association of incidentally detected heart valve calcification with future cardiovascular events

Abstract

Objectives

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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