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European Radiology
Published in: European Radiology 4/2011

Open Access 01-04-2011 | Neuro

Distribution of cerebral blood flow in the caudate nucleus, lentiform nucleus and thalamus in patients with carotid artery stenosis

Authors: Nolan S. Hartkamp, Reinoud P. H. Bokkers, H. Bart van der Worp, M. J. P. van Osch, L. Jaap Kappelle, Jeroen Hendrikse

Published in: European Radiology | Issue 4/2011

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Abstract

Objective

To investigate the influence of internal carotid artery (ICA) stenosis on the distribution of blood flow to the caudate nucleus, lentiform nucleus, and thalamus.

Methods

We studied 18 healthy control subjects, 20 patients with a unilateral asymptomatic ICA stenosis, and 15 patients with a recently symptomatic unilateral ICA stenosis. The contribution of the ICAs and the basilar artery to the perfusion of the deep brain structures was assessed by perfusion territory selective arterial spin labeling (ASL) MRI. Differences were tested with a two-tailed Fishers’ exact test.

Results

The caudate nucleus was predominantly supplied with blood by the ipsilateral ICA in all groups. In 4 of the 15 (27%) the symptomatic patients, the caudate nucleus partially received blood from the contralateral ICA, compared to none of the 18 healthy control subjects (p = 0.03). The lentiform nucleus and the thalamus were predominantly supplied with blood by the ipsilateral ICA and basilar artery respectively in all groups.

Conclusion

In patients with a symptomatic ICA stenosis, the caudate nucleus may be supplied with blood by the contralateral ICA more often than in healthy controls.
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Metadata
Title
Distribution of cerebral blood flow in the caudate nucleus, lentiform nucleus and thalamus in patients with carotid artery stenosis
Authors
Nolan S. Hartkamp
Reinoud P. H. Bokkers
H. Bart van der Worp
M. J. P. van Osch
L. Jaap Kappelle
Jeroen Hendrikse
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 4/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1952-y

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