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01-06-2010 | Hepatobiliary-Pancreas

Diagnosis of liver metastases: value of diffusion-weighted MRI compared with gadolinium-enhanced MRI

Authors: Andrew D. Hardie, Mohit Naik, Elizabeth M. Hecht, Hersh Chandarana, Lorenzo Mannelli, James S. Babb, Bachir Taouli

Published in: European Radiology | Issue 6/2010

Abstract

Objective

The full diagnostic value of diffusion-weighted (DW) MRI in the evaluation of liver metastases remains uncertain. The aim of the present study was to assess the diagnostic accuracy of DW-MRI and contrast-enhanced MRI (CE-MRI) using extracellular gadolinium chelates, with the reference standard established by consensus interpretation of confirmatory imaging and histopathologic data.

Methods

MR examinations of 51 patients with extrahepatic malignancies were retrospectively reviewed by two independent observers who assessed DW-MRI and CE-MRI for detection of liver metastases.

Results

By reference standard, 93 liver lesions (49 metastases and 44 benign lesions) were identified in 27 patients, 11 patients had no liver lesions, and 13 patients had innumerable metastatic and/or benign lesions. There was no difference in diagnostic performance between the two methods for either observer for the diagnosis of metastatic lesions per patient. For per-lesion analysis, sensitivity of DW-MRI was equivalent to CE-MRI for observer 1 (67.3% vs. 63.3%, p = 0.67), but lower for observer 2 (65.3% vs. 83.7%, p = 0.007). By pooling data from both observers, the sensitivity of DW-MRI was 66.3% (65/98) and 73.5% (72/98) for CE-MRI, with no significant difference (p = 0.171).

Conclusion

DW-MRI is a reasonable alternative to CE-MRI for the detection of liver metastases.

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Title: Diagnosis of liver metastases: value of diffusion-weighted MRI compared with gadolinium-enhanced MRI
Authors: Andrew D. Hardie
Mohit Naik
Elizabeth M. Hecht
Hersh Chandarana
Lorenzo Mannelli
James S. Babb
Bachir Taouli
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: European Radiology / Issue 6/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1695-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diagnosis of liver metastases: value of diffusion-weighted MRI compared with gadolinium-enhanced MRI

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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