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01-12-2009 | Chest

Assessment of lobar perfusion in smokers according to the presence and severity of emphysema: preliminary experience with dual-energy CT angiography

Authors: Vittorio Pansini, Martine Remy-Jardin, Jean-Baptiste Faivre, Bernhard Schmidt, Alexis Dejardin-Bothelo, Thierry Perez, Valérie Delannoy, Alain Duhamel, Jacques Remy

Published in: European Radiology | Issue 12/2009

Abstract

The purpose of the study was to assess pulmonary perfusion on a lobar level in smokers using dual-energy computed tomography (CT). Forty-seven smokers and ten non-smokers underwent a dual-energy multi-detector CT angiogram of the chest that allowed automatic quantification of emphysema and determination of the iodine content at the level of the microcirculation (i.e. “perfusion imaging”). Emphysema was present in 37 smokers and absent in ten smokers. Smokers with an upper lobe predominance of emphysema (n = 8) had: (1) significantly lower attenuation enhancement values in the upper lobes compared with smokers without emphysema; (2) the lobes with the most severe emphysematous changes had a statistically significantly higher percentage of emphysema (p = 0.0001) and lower mean attenuation enhancement values (p = 0.0001) than the ipsilateral lobes with less severe emphysema, matching parenchymal destruction; (3) a correlation was found between the difference in percentage of emphysema between the upper and lower lobes and the difference in attenuation attenuation enhancement values in the corresponding lobes (p = 0.0355; r = −0.54). Regional alterations of lung perfusion can be depicted by dual-energy CT in smokers with predominant emphysema.

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Title: Assessment of lobar perfusion in smokers according to the presence and severity of emphysema: preliminary experience with dual-energy CT angiography
Authors: Vittorio Pansini
Martine Remy-Jardin
Jean-Baptiste Faivre
Bernhard Schmidt
Alexis Dejardin-Bothelo
Thierry Perez
Valérie Delannoy
Alain Duhamel
Jacques Remy
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: European Radiology / Issue 12/2009
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1475-6

Keynote webinar | Spotlight on medication adherence

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Assessment of lobar perfusion in smokers according to the presence and severity of emphysema: preliminary experience with dual-energy CT angiography

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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