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01-10-2008 | Head and Neck

Functional CT of squamous cell carcinoma in the head and neck: repeatability of tumor and muscle quantitative measurements, inter- and intra-observer agreement

Authors: Sotirios Bisdas, Katarina Surlan-Popovic, Vojko Didanovic, Thomas J. Vogl

Published in: European Radiology | Issue 10/2008

Abstract

Our purpose was to determine the repeatability of squamous cell cancer in head and neck (SCCHN) and muscle tissue vascularity measurements as well as the inter- and intra-observer agreement using dynamic contrast-enhanced (DCE) multi-detector CT (MDCT). Twelve patients with histologically proven SCCHN were twice examined within 46 h. Measurement error and repeatability were assessed for each of the four functional parameters using the Bland-Altman plots. Two independent observers recorded the vascularity values of the tumor tissue; inter- and intra-observer agreement was assessed using the Bland-Altman plot analysis and intraclass correlation coefficients. For the tumor, the mean difference (95% limits of agreement) was 0.40 ml/min/100 g tissue (−6.80, 9.60); 0.01 (−0.96, 0.97) ml/100 g tissue; 0.20 (−1.80, 2.30) s; and 0.40 (−2.00, 2.80) ml/min/100 g tissue for BF, BV, MTT, and PS, respectively. For the muscle, the mean difference (95% limits of agreement) was −0.18 (−1.70, 1.35), 0.04 (−1.17, 1.35), −0.10 (−5.80, 5.60), and −0.10 (−2.20, 2.00), respectively. Measurement changes of at least ±8%, 30%, 36%, and 13% were found to be significant for BF, BV, MTT, and PS, respectively. There was better intra- than inter-observer agreement.

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Title: Functional CT of squamous cell carcinoma in the head and neck: repeatability of tumor and muscle quantitative measurements, inter- and intra-observer agreement
Authors: Sotirios Bisdas
Katarina Surlan-Popovic
Vojko Didanovic
Thomas J. Vogl
Publication date: 01-10-2008
Publisher: Springer-Verlag
Published in: European Radiology / Issue 10/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-008-0990-1

2024 ASCO Annual Meeting

Springer Medicine

Functional CT of squamous cell carcinoma in the head and neck: repeatability of tumor and muscle quantitative measurements, inter- and intra-observer agreement

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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