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01-03-2008 | Hepatobiliary-Pancreas

Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique

Authors: Melanie Bruegel, Konstantin Holzapfel, Jochen Gaa, Klaus Woertler, Simone Waldt, Berthold Kiefer, Alto Stemmer, Carl Ganter, Ernst J. Rummeny

Published in: European Radiology | Issue 3/2008

Abstract

The aim of this study was to determine apparent diffusion coefficients (ADCs) of focal liver lesions on the basis of a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging sequence (DW-SS-EPI) and to evaluate whether ADC measurements can be used to characterize lesions. One hundred and two patients with focal liver lesions [11 hepatocellular carcinomas (HCC), 82 metastases, 4 focal nodular hyperplasias (FNH), 56 hemangiomas and 51 cysts; mean size, 16.6 mm; range 5–92 mm] were examined on a 1.5-T system using respiratory triggered DW-SS-EPI (b-values: 50, 300, 600 s/mm²). Results were correlated with histopathologic data and follow-up imaging. The ADCs of different lesion types were compared, and lesion discrimination using optimal thresholds for ADCs was evaluated. Mean ADCs (×10⁻³mm²/s) were 1.24 and 1.04 for normal and cirrhotic liver parenchyma and 1.05, 1.22, 1.40, 1.92 and 3.02 for HCCs, metastases, FNHs, hemangiomas and cysts, respectively. Mean ADCs differed significantly for all lesion types except for comparison of metastases with HCCs and FNHs. Overall, 88% of lesions were correctly classified as benign or malignant using a threshold value of 1.63 × 10⁻³mm²/s. Measurements of the ADCs of focal liver lesions on the basis of a respiratory triggered DW-SS-EPI sequence may constitute a useful supplementary method for lesion characterization.

Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T (1998) Diffusion-weighted MR imaging with a single-shot echoplanar sequence: detection and characterization of focal hepatic lesions. AJR Am J Roentgenol 170:397–402PubMed

Nasu K, Kuroki Y, Nawano S et al (2006) Hepatic metastases: diffusion-weighted sensitivity-encoding versus SPIO-enhanced MR imaging. Radiology 239:122–130PubMedCrossRef

Okada Y, Ohtomo K, Kiryu S, Sasaki Y (1998) Breath-hold T2-weighted MRI of hepatic tumors: value of echo planar imaging with diffusion-sensitizing gradient. J Comput Assist Tomogr 22:364–371PubMedCrossRef

Le Bihan D, Breton E, Lallemand D et al (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505PubMed

Marks MP, de Crespigny A, Lentz D et al (1996) Acute and chronic stroke: navigated spin-echo diffusion-weighted MR imaging. Radiology 199:403–408PubMed

Sugahara T, Korogi Y, Kochi M et al (1999) Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 9:53–60PubMedCrossRef

Bammer R (2003) Basic principles of diffusion-weighted imaging. Eur J Radiol 45:169–184PubMedCrossRef

Turner R, Le Bihan D, Maier J et al (1990) Echo-planar imaging of intravoxel incoherent motion. Radiology 177:407–414PubMed

Thoeny HC, De Keyzer F (2007) Extracranial applications of diffusion-weighted magnetic resonance imaging. Eur Radiol 17:1385–1393PubMedCrossRef

10.

Kim T, Murakami T, Takahashi S et al (1999) Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol 173:393–398PubMed

11.

Namimoto T, Yamashita Y, Sumi S, Tang Y, Takahashi M (1997) Focal liver masses: characterization with diffusion-weighted echo-planar MR imaging. Radiology 204:739–744PubMed

12.

Sun XJ, Quan XY, Huang FH, Xu YK (2005) Quantitative evaluation of diffusion-weighted magnetic resonance imaging of focal hepatic lesions. World J Gastroenterol 11:6535–6537PubMed

13.

Taouli B, Vilgrain V, Dumont E et al (2003) Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology 226:71–78PubMedCrossRef

14.

Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H (1999) Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology 210:617–623PubMed

15.

Amano Y, Kumazaki T, Ishihara M (1998) Single-shot diffusion-weighted echo-planar imaging of normal and cirrhotic livers using a phased-array multicoil. Acta Radiol 39:440–442PubMedCrossRef

16.

Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T (1999) Diffusion-weighted MR imaging with single-shot echo-planar imaging in the upper abdomen: preliminary clinical experience in 61 patients. Abdom Imaging 24:456–461PubMedCrossRef

17.

Deng J, Miller FH, Rhee TK et al (2006) Diffusion-weighted MR imaging for determination of hepatocellular carcinoma response to yttrium-90 radioembolization. J Vasc Interv Radiol 17:1195–1200PubMedCrossRef

18.

Deng J, Rhee TK, Sato KT et al (2006) In vivo diffusion-weighted imaging of liver tumor necrosis in the VX2 rabbit model at 1.5 Tesla. Invest Radiol 41:410–414PubMedCrossRef

19.

Yoshikawa T, Kawamitsu H, Mitchell DG et al (2006) ADC measurement of abdominal organs and lesions using parallel imaging technique. AJR Am J Roentgenol 187:1521–1530PubMedCrossRef

20.

Koh DM, Scurr E, Collins DJ et al (2006) Colorectal hepatic metastases: quantitative measurements using single-shot echo-planar diffusion-weighted MR imaging. Eur Radiol 16:1898–1905PubMedCrossRef

21.

Taouli B, Martin AJ, Qayyum A et al (2004) Parallel imaging and diffusion tensor imaging for diffusion-weighted MRI of the liver: preliminary experience in healthy volunteers. AJR Am J Roentgenol 183:677–680PubMed

22.

Bartolozzi C, Cioni D, Donati F, Lencioni R (2001) Focal liver lesions: MR imaging-pathologic correlation. Eur Radiol 11:1374–1388PubMedCrossRef

23.

Horton KM, Bluemke DA, Hruban RH, Soyer P, Fishman EK (1999) CT and MR imaging of benign hepatic and biliary tumors. Radiographics 19:431–451PubMed

24.

Heid O (2000) Eddy Current-Nulled Diffusion Weighting. Proc Intl Soc Mag Reson Med 8: abstract number 799

25.

Stejskal EO, Tanner JE (1965) Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 42:288–292CrossRef

26.

Griswold MA, Jakob PM, Heidemann RM et al (2002) Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 47:1202–1210PubMedCrossRef

27.

Sandberg A, Parikh T, Johnson G, Stemmer A, Taouli B (2006) Feasibility of a respiratory-triggered SSEPI diffusion-weighted sequence for liver imaging using navigator echo technique: comparison with breath-hold diffusion-weighted sequence. Proc Intl Soc Mag Reson Med 14: abstract number 400

28.

Nasu K, Kuroki Y, Sekiguchi R, Nawano S (2006) The effect of simultaneous use of respiratory triggering in diffusion-weighted imaging of the liver. Magn Reson Med Sci 5:129–136PubMedCrossRef

29.

Mürtz P, Flacke S, Traber F et al (2002) Abdomen: diffusion-weighted MR imaging with pulse-triggered single-shot sequences. Radiology 224:258–264PubMedCrossRef

30.

Jones DK, Basser PJ (2004) “Squashing peanuts and smashing pumpkins”: how noise distorts diffusion-weighted MR data. Magn Reson Med 52:979–993PubMedCrossRef

31.

Chow LC, Bammer R, Moseley ME, Sommer FG (2003) Single breath-hold diffusion-weighted imaging of the abdomen. J Magn Reson Imaging 18:377–382PubMedCrossRef

32.

Müller MF, Prasad P, Siewert B et al (1994) Abdominal diffusion mapping with use of a whole-body echo-planar system. Radiology 190:475–478PubMed

33.

Vilgrain V, Boulos L, Vullierme MP et al (2000) Imaging of atypical hemangiomas of the liver with pathologic correlation. Radiographics 20:379–397PubMed

34.

Cieszanowski A, Szeszkowski W, Golebiowski M et al (2002) Discrimination of benign from malignant hepatic lesions based on their T2-relaxation times calculated from moderately T2-weighted turbo SE sequence. Eur Radiol 12:2273–2279PubMed

35.

Farraher SW, Jara H, Chang KJ, Ozonoff A, Soto JA (2006) Differentiation of hepatocellular carcinoma and hepatic metastasis from cysts and hemangiomas with calculated T2 relaxation times and the T1/T2 relaxation times ratio. J Magn Reson Imaging 24:1333–1341PubMedCrossRef

36.

Fenlon HM, Tello R, DeCarvalho VL, Yucel EK (2000) Signal characteristics of focal liver lesions on double echo T2-weighted conventional spin echo MRI: observer performance versus quantitative measurements of T2 relaxation times. J Comput Assist Tomogr 24:204–211PubMedCrossRef

Title: Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique
Authors: Melanie Bruegel
Konstantin Holzapfel
Jochen Gaa
Klaus Woertler
Simone Waldt
Berthold Kiefer
Alto Stemmer
Carl Ganter
Ernst J. Rummeny
Publication date: 01-03-2008
Publisher: Springer-Verlag
Published in: European Radiology / Issue 3/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-007-0785-9

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Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique

Abstract

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Abstract

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