Top

Published in:

01-09-2007 | Experimental

Late-phase MSCT in the different stages of myocardial infarction: animal experiments

Authors: Andreas H. Mahnken, Philipp Bruners, Sylvia Kinzel, Marcus Katoh, Georg Mühlenbruch, Rolf W. Günther, Joachim E. Wildberger

Published in: European Radiology | Issue 9/2007

Abstract

The purpose of this study was to intraindividually evaluate myocardial late enhancement on multislice spiral computed tomography (MSCT) for the assessment of the different stages of myocardial infarction (MI) in comparison with magnetic resonance (MR) imaging. Reperfused MI was successfully induced in seven pigs. Delayed enhancement MR imaging and late-phase MSCT were performed on day 0 as well as 7, 28 and 90 days after the procedure. The pigs were sacrificed, and 2,3,5-triphenyltetrazolin-chloride (TTC) staining was acquired. MI size was compared between the different imaging techniques and over time applying Bland-Altman plots and multivariate analysis with repeated measures. On day 0 the mean MI size was 23.7 ± 11.8% of the left ventricular area on MSCT and 24.5 ± 10.6% on MR imaging. On day 90 infarct sizes decreased significantly to 16.9 ± 8.4% and 18.9 ± 8.0%, respectively (P = 0.0019). On TTC staining the size of MI was 16.8 ± 8.2%. Bland-Altman plots showed a good agreement between MSCT and MR imaging with mean deviations ranging from −3.4% to −1.9%. No significant difference between MSCT and MR imaging was found. Myocardial late enhancement on MSCT correlates well with delayed enhancement MR imaging during the different stages of MI and allows for reliable assessment of reperfused MI during acute, subacute and chronic stages.

American Heart Association (2006) Heart disease and stroke statistics-2006 update. American Heart Association, Dallas

Gersh BJ, Anderson JL (1993) Thrombolysis and myocardial salvage. Results of clinical trials and the animal paradigm-paradoxic or predictable? Circulation 88:296–306PubMed

Rahimtoola SH (1985) A perspective on the three large multicenter randomised clinical trials of coronary bypass surgery for chronic stable angina. Circulation 72:V123–V135PubMed

Allman KC, Shaw LJ, Hachamovitch R, Udelson JE (2002) Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol 39:1151–1158PubMedCrossRef

Constantine G, Shan K, Flamm SD, Sivananthan MU (2004) Role of MRI in clinical cardiology. Lancet 363:2162–2171PubMedCrossRef

Hillenbrand HB, Kim RJ, Parker MA, Fieno DS, Judd RM (2000) Early assessment of myocardial salvage by contrast-enhanced magnetic resonance imaging. Circulation 102:1678–1683PubMed

Simonetti OP, Kim RJ, Fieno DS, Hillenbrand HB, Wu E, Bundy JM, Finn JP, Judd RM (2001) An improved MR imaging technique for the visualization of myocardial infarction. Radiology 218:215–223PubMed

Thomson LE, Kim RJ, Judd RM (2004) Magnetic resonance imaging for the assessment of myocardial viability. J Magn Reson Imaging 19:771–788PubMedCrossRef

Lardo AC, Cordeiro MA, Silva C, Amado LC, George RT, Saliaris AP, Schuleri KH, Fernandes VR, Zviman M, Nazarian S, Halperin HR, Wu KC, Hare JM, Lima JA (2006) Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation 113:394–404PubMedCrossRef

10.

Mahnken AH, Koos R, Katoh M, Wildberger JE, Spuentrup E, Buecker A, Gunther RW, Kuhl HP (2005) Assessment of myocardial viability in reperfused acute myocardial infarction using 16-slice computed tomography in comparison to magnetic resonance imaging. J Am Coll Cardiol 45:2042–2047PubMedCrossRef

11.

Mahnken AH, Bruners P, Katoh M, Wildberger JE, Gunther RW, Buecker A (2006) Dynamic multi-section CT imaging in acute myocardial infarction: preliminary animal experience. Eur Radiol 16:746–752PubMedCrossRef

12.

Brodoefel H, Klumpp B, Reimann A, Ohmer M, Fenchel M, Schroeder S, Miller S, Claussen C, Kopp AF, Scheule AM (2006) Late myocardial enhancement assessed by 64-MSCT in reperfused porcine myocardial infarction: diagnostic accuracy of low-dose CT protocols in comparison with magnetic resonance imaging. Eur Radiol Jun 27; DOI 10.1007/s00330-006-0334-y

13.

Baks T, Cademartiri F, Moelker AD AC, van Geuns RJ, Mollet NR, Krestin GP, Duncker DJ, de Feyter PJ (2006) Multislice computed tomography and magnetic resonance imaging for the assessment of reperfused acute myocardial infarction. J Am Coll Cardiol 48:144–152PubMedCrossRef

14.

Thompson BH, Stanford W (1994) Evaluation of cardiac function with ultrafast computed tomography. Radiol Clin North Am 32:537–551PubMed

15.

Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, Bundy J, Finn JP, Klocke FJ, Judd RM (1999) Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 100:1992–2002PubMed

16.

Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, Klocke FJ, Bonow RO, Kim RJ, Judd RM (2003) Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 361:374–379PubMedCrossRef

17.

Buecker A, Katoh M, Krombach GA, Spuentrup E, Bruners P, Gunther RW, Niendorf T, Mahnken AH (2005) A feasibility study of contrast enhancement of acute myocardial infarction in multislice computed tomography: comparison with magnetic resonance imaging and gross morphology in pigs. Invest Radiol 40:700–704PubMedCrossRef

18.

Gerber BL, Belge B, Legros GJ, Lim P, Poncelet A, Pasquet A, Gisellu G, Coche E, Vanoverschelde JLJ (2006) Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: comparison with contrast-enhanced magnetic resonance. Circulation 113:823–833PubMedCrossRef

19.

Nieman K, Cury RC, Ferencik M, Nomura CH, Abbara S, Hoffmann U, Gold HK, Jang IK, Brady TJ (2006) Differentiation of recent and chronic myocardial infarction by cardiac computed tomography. Am J Cardiol 98:303–308PubMedCrossRef

20.

Nishimura T, Kobayashi H, O’hara Y, Yamada N, Haze K, Takamiya M, Hiramori K (1989) Serial assessment of myocardial infarction by using gated MR imaging and Gd-DTPA. Am J Roentgenol 153:715–720

21.

Eichstaedt HW, Felix R, Dougherty FC, Langer M, Rutsch W, Schmutzler H (1986) Magnetic resonance imaging (MRI) in different stages of myocardial infarction using the contrast agent gadolinium-DTPA. Clin Cardiol 9:527–535PubMedCrossRef

22.

van Dijkman PRM, van der Wall EE, de Roos A, Matheijssen NAA, van Rossum AC, Doombos J, van der Laarse A, van Voorthuisen AE, Bruschke AVG (1991) Acute, subacute, and chronic myocardial infarction: quantitative analysis of gadolinium-enhanced MR images. Radiology 180:147–151PubMed

23.

Wu E, Judd RM, Vargas JD, Klocke FJ, Bonow RO, Kim RJ (2001) Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 357:21–28PubMedCrossRef

24.

Rehwald WG, Fieno DS, Chen EL, Kim RJ, Judd RM (2002) Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation 105:224–229PubMedCrossRef

25.

Kim R, Chen EL, Lima JAC, Judd RM (1996) Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury following acute reperfused infarction. Circulation 94:3318–3326PubMed

26.

Ambrosio G, Tritto I (1999) Reperfusion injury: experimental evidence and clinical implications. Am Heart J 138:S69–S75PubMedCrossRef

27.

Judd RM, Lugo-Olivieri CH, Arai M, Kondo T, Croisille P, Lima JA, Mohan V, Becker LC, Zerhouni EA (1995) Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. Circulation 92:1902–1910PubMed

28.

Abdel-Aty H, Zagrosek A, Schulz-Menger J, Taylor AJ, Messroghli D, Kumar A, Gross M, Dietz R, Friedrich MG (2004) Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation 109:2411–2416PubMedCrossRef

29.

Wu KC, Kim RJ, Bluemke DA, Rochitte CE, Zerhouni EA, Becker LC, Lima JA (1998) Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion. J Am Coll Cardiol 32:1756–1764PubMedCrossRef

30.

Reimer KA, Jennings RB (1992) Myocardial ischemia, hypoxia and infarction. In: Fozzard HA, Haber E, Jennings RB (eds) The heart of cardiovascular system, 2nd edn. Raven Press, New York, pp 1875–1973

31.

Raff GL, Gallagher MJ, O’Neill WW, Goldstein JA (2005) Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography. J Am Coll Cardiol 46:552–557PubMedCrossRef

32.

Mahnken AH, Katoh M, Bruners P, Spuentrup E, Wildberger JE, Gunther RW, Buecker A (2005) Acute myocardial infarction: assessment of left ventricular function with 16-detector row spiral CT versus MR imaging-study in pigs. Radiology 236:112–117PubMedCrossRef

Title: Late-phase MSCT in the different stages of myocardial infarction: animal experiments
Authors: Andreas H. Mahnken
Philipp Bruners
Sylvia Kinzel
Marcus Katoh
Georg Mühlenbruch
Rolf W. Günther
Joachim E. Wildberger
Publication date: 01-09-2007
Publisher: Springer-Verlag
Published in: European Radiology / Issue 9/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-006-0569-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Late-phase MSCT in the different stages of myocardial infarction: animal experiments

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 9/2007

Encephalitis following Mycoplasma pneumonia (2007: 6b)

Imaging the cranial nerves: part II: primary and secondary neoplastic conditions and neurovascular conflicts

Endovascular optical coherence tomography ex vivo: venous wall anatomy and tissue alterations after endovenous therapy

Comparison of sonoelastography guided biopsy with systematic biopsy: impact on prostate cancer detection

Unenhanced helical computed tomography vs intravenous urography in patients with acute flank pain: accuracy and economic impact in a randomized prospective trial

The intravertebral vacuum phenomen as specific sign of osteonecrosis in vertebral compression fractures: results from a radiological and histological study