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European Radiology
Published in: European Radiology 12/2006

01-12-2006 | Musculoskeletal

Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: initial results

Authors: Yoshiko Hayashida, Toshitake Yakushiji, Kazuo Awai, Kazuhiro Katahira, Yoshiharu Nakayama, Osamu Shimomura, Mika Kitajima, Toshinori Hirai, Yasuyuki Yamashita, Hiroshi Mizuta

Published in: European Radiology | Issue 12/2006

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Abstract

The purpose of our study was to investigate whether quantitative diffusion-weighted images (DWI) were useful for monitoring the therapeutic response of primary bone tumors. We encountered 18 osteogenic and Ewing sarcomas. Magnetic resonance (MR) images were performed in all patients before and after therapy. We measured the apparent diffusion coefficient (ADC) values, contrast-to-noise ratio (CNR), and tumor volume of the bone tumors pre- and posttreatment. We determined change in ADC value, change in CNR on T2-weighted images (T2WI), change in CNR on gadopentetate dimeglumine (Gd)-T1-weighted images (Gd-T1WI), and change in tumor volume. The bone tumors were divided into two groups: group A was comprised of tumors with less than 90% necrosis after treatment and group B of tumors at least with 90%. Changes in ADC value, tumor volume, and CNR were compared between the groups. Change in the ADC value was statistically greater in group B than that in the group A (p=0.003). There was no significant difference in the changes in CNR on T2WI (p=0.683), in CNR on Gd-T1WI (p=0.763), and tumor volume (p=0.065). The ADC value on DWI is a promising tool for monitoring the therapeutic response of primary bone sarcomas.

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Metadata
Title
Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: initial results
Authors
Yoshiko Hayashida
Toshitake Yakushiji
Kazuo Awai
Kazuhiro Katahira
Yoshiharu Nakayama
Osamu Shimomura
Mika Kitajima
Toshinori Hirai
Yasuyuki Yamashita
Hiroshi Mizuta
Publication date
01-12-2006
Publisher
Springer-Verlag
Published in
European Radiology / Issue 12/2006
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-006-0342-y

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