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Published in: European Radiology 6/2006

01-06-2006 | Hepatobiliary-Pancreas

Detection and characterization of liver metastases: 16--slice multidetector computed tomography versus superparamagnetic iron oxide-enhanced magnetic resonance imaging

Authors: Young Kon Kim, Seog Wan Ko, Seung Bae Hwang, Chong Soo Kim, Hee Chul Yu

Published in: European Radiology | Issue 6/2006

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Abstract

The aim of our study was to compare the diagnostic performance of 16--slice multidetector computed tomography with that of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging in the detection of small hepatic metastases and in the differentiation of hepatic metastases from cysts. Twenty-three patients with 55 liver metastases and 14 liver cysts underwent SPIO-enhanced MR imaging and multiphasic CT using 16-MDCT. Two observers independently analyzed each image, in random order. Sensitivity and diagnostic accuracy for lesion detection and differentiation as metastases or cysts for MDCT and SPIO-enhanced MR imaging were calculated using receiver operating characteristic analysis. For all observers, the Az values of SPIO-enhanced MR imaging for lesion detection and differentiation of liver metastases from cysts (mean 0.955, 0.999) were higher than those of MDCT (mean 0.925, 0.982), but not statistically significantly so (P>0.05). Sensitivity of SPIO-enhanced MR imaging with regard to the detection of liver metastases (mean 94.5%) was significantly higher than that of MDCT (mean 80.0%) (P<0.05). SPIO-enhanced MR imaging and 16-MDCT showed similar diagnostic accuracies for detection and differentiation of liver metastases from cysts, but sensitivity of SPIO-enhanced imaging in the detection of liver metastases was superior to that of 16-MDCT.
Literature
1.
go back to reference Hagspiel KD, Neidel KFW, Eichenberger AC, Weder W, Marincek B (1995) Detection of liver metastases: comparison of superparamagnetic iron-oxide-enhanced MR imaging at 1.5 T with dynamic CT, intraoperative US, and percutaneous US. Radiology 196:471–478PubMed Hagspiel KD, Neidel KFW, Eichenberger AC, Weder W, Marincek B (1995) Detection of liver metastases: comparison of superparamagnetic iron-oxide-enhanced MR imaging at 1.5 T with dynamic CT, intraoperative US, and percutaneous US. Radiology 196:471–478PubMed
2.
go back to reference Ward J, Naik KS, Guthrie JA, Wilson D, Robinson PJ (1999) Hepatic lesion detection: comparison of MR imaging after the administration of superparamagnetic iron oxide with dual-phase CT by using alternative free response receiver operating characteristic analysis. Radiology 210:459–466PubMed Ward J, Naik KS, Guthrie JA, Wilson D, Robinson PJ (1999) Hepatic lesion detection: comparison of MR imaging after the administration of superparamagnetic iron oxide with dual-phase CT by using alternative free response receiver operating characteristic analysis. Radiology 210:459–466PubMed
3.
go back to reference Semelka RC, Brown ED, Ascher SM, Patt RH, Bagley AS, Li W, Edelman RR, Shoenut JP, Brown JJ (1994) Solitary hepatic metastasis: comparison of dynamic contrast-enhanced CT and MR imaging with fat-suppressed T2-weighted, breath-hold T1-weighted FLASH, and dynamic gadolinium-enhanced FLASH sequences. J Magn Reson Imaging 4:319–323PubMedCrossRef Semelka RC, Brown ED, Ascher SM, Patt RH, Bagley AS, Li W, Edelman RR, Shoenut JP, Brown JJ (1994) Solitary hepatic metastasis: comparison of dynamic contrast-enhanced CT and MR imaging with fat-suppressed T2-weighted, breath-hold T1-weighted FLASH, and dynamic gadolinium-enhanced FLASH sequences. J Magn Reson Imaging 4:319–323PubMedCrossRef
4.
go back to reference Bartolozzi C, Donati F, Cioni D, Procacci C, Morana G, Chiesa A, Grazioli L, Cittadini G, Cittadini G, Giovagnoni A, Gandini G, Maass J, Lencioni R (2004) Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT. Eur Radiol 14:14–20CrossRefPubMed Bartolozzi C, Donati F, Cioni D, Procacci C, Morana G, Chiesa A, Grazioli L, Cittadini G, Cittadini G, Giovagnoni A, Gandini G, Maass J, Lencioni R (2004) Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT. Eur Radiol 14:14–20CrossRefPubMed
5.
go back to reference Kim KW, Kim AY, Kim TK, Park SH, Kim HJ, Lee YK, Park MS, Ha HK, Kim PN, Kim JC, Lee MG (2004) Small (≤ 2 cm) hepatic lesions in colorectal cancer patients: detection and characterization on mangafodipir trisodium-enhanced MRI. AJR Am J Roentgenol 182:1233–1240PubMed Kim KW, Kim AY, Kim TK, Park SH, Kim HJ, Lee YK, Park MS, Ha HK, Kim PN, Kim JC, Lee MG (2004) Small (≤ 2 cm) hepatic lesions in colorectal cancer patients: detection and characterization on mangafodipir trisodium-enhanced MRI. AJR Am J Roentgenol 182:1233–1240PubMed
6.
go back to reference Torres CG, Lundby B, Sterud AT, McGill S, Gordon PB, Bjerknes HS (1997) MnDPDP for MR imaging of the liver: results from the European phase III studies. Acta Radiol 38:631–637PubMedCrossRef Torres CG, Lundby B, Sterud AT, McGill S, Gordon PB, Bjerknes HS (1997) MnDPDP for MR imaging of the liver: results from the European phase III studies. Acta Radiol 38:631–637PubMedCrossRef
7.
go back to reference Jones EC, Chezmar JL, Nelson RC, Bernardino ME (1992) The frequency and significance of small hepatic lesions (<15 mm) detected by CT. AJR Am J Roentgenol 158:535–539PubMed Jones EC, Chezmar JL, Nelson RC, Bernardino ME (1992) The frequency and significance of small hepatic lesions (<15 mm) detected by CT. AJR Am J Roentgenol 158:535–539PubMed
8.
go back to reference Haider MA, Amitai MM, Rappaport DC, O’Malley ME, Hanbidge AE, Redston M, Lockwood GA, Gallinger S (2002) Multi-detector row helical CT in preoperative assessment of small (≤ 1.5 cm) liver metastases: is thinner collimation better? Radiology 225:137–142PubMedCrossRef Haider MA, Amitai MM, Rappaport DC, O’Malley ME, Hanbidge AE, Redston M, Lockwood GA, Gallinger S (2002) Multi-detector row helical CT in preoperative assessment of small (≤ 1.5 cm) liver metastases: is thinner collimation better? Radiology 225:137–142PubMedCrossRef
9.
go back to reference Krakora GA, Coakley FV, Williams G, Yeh BM, Breiman RS, Qayyum A (2004) Small hypoattenuating hepatic lesions at contrast-enhanced CT: prognostic importance in patients with breast cancer. Radiology 233:667–673PubMedCrossRef Krakora GA, Coakley FV, Williams G, Yeh BM, Breiman RS, Qayyum A (2004) Small hypoattenuating hepatic lesions at contrast-enhanced CT: prognostic importance in patients with breast cancer. Radiology 233:667–673PubMedCrossRef
10.
go back to reference Tsushima K, Nishie A, Yoshimitsu K, Taketomi A, Honda H (2005) Liver metastasis with apparent intratumoral superparamagnetic iron oxide uptake. Eur Radiol 15:2203–2204CrossRefPubMed Tsushima K, Nishie A, Yoshimitsu K, Taketomi A, Honda H (2005) Liver metastasis with apparent intratumoral superparamagnetic iron oxide uptake. Eur Radiol 15:2203–2204CrossRefPubMed
11.
go back to reference Takahama K, Amano Y, Hayashi H, Ishihara M, Kumazaki T (2003) Detection and characterization of focal liver lesions using superparamagnetic iron oxide-enhanced magnetic resonance imaging: comparison between ferumoxides-enhanced T1-weighted imaging and delayed-phase gadolinium-enhanced T1-weighted imaging. Abdom Imaging 28:525–530CrossRefPubMed Takahama K, Amano Y, Hayashi H, Ishihara M, Kumazaki T (2003) Detection and characterization of focal liver lesions using superparamagnetic iron oxide-enhanced magnetic resonance imaging: comparison between ferumoxides-enhanced T1-weighted imaging and delayed-phase gadolinium-enhanced T1-weighted imaging. Abdom Imaging 28:525–530CrossRefPubMed
12.
go back to reference Reimer P, Jahnke N, Fiebich M, Schima W, Deckers F, Marx C, Holzknecht N, Saini S (2000) Hepatic lesion detection and characterization: value of nonenhanced MR imaging, superparamagnetic iron oxide-enhanced MR imaging, and spiral CT-ROC analysis. Radiology 217:152–158PubMed Reimer P, Jahnke N, Fiebich M, Schima W, Deckers F, Marx C, Holzknecht N, Saini S (2000) Hepatic lesion detection and characterization: value of nonenhanced MR imaging, superparamagnetic iron oxide-enhanced MR imaging, and spiral CT-ROC analysis. Radiology 217:152–158PubMed
13.
go back to reference Kim YK, Lee JM, Kim CS, Lee YH (2004) Gadobenate dimeglumine-enhanced liver MR imaging: value of delayed imaging for the characterization and detection of focal liver lesions. Eur Radiol 14:5–13CrossRefPubMed Kim YK, Lee JM, Kim CS, Lee YH (2004) Gadobenate dimeglumine-enhanced liver MR imaging: value of delayed imaging for the characterization and detection of focal liver lesions. Eur Radiol 14:5–13CrossRefPubMed
14.
go back to reference Kim YK, Lee JM, Kim CS, Chung GH, Kim CY, Kim IH (2005) Detection of liver metastases: gadobenate dimeglumine-enhanced three-dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced MR imaging. Eur Radiol 15:220–228CrossRefPubMed Kim YK, Lee JM, Kim CS, Chung GH, Kim CY, Kim IH (2005) Detection of liver metastases: gadobenate dimeglumine-enhanced three-dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced MR imaging. Eur Radiol 15:220–228CrossRefPubMed
15.
go back to reference Hu H, He HD, Foley WD, Fox SH (2000) Four multidetector-row helical CT: image quality and volume coverage speed. Radiology 215:55–62PubMed Hu H, He HD, Foley WD, Fox SH (2000) Four multidetector-row helical CT: image quality and volume coverage speed. Radiology 215:55–62PubMed
16.
go back to reference Berland LL, Smith JK (1998) Multidetector-array CT: once again, technology creates new opportunities. Radiology 209:327–329PubMed Berland LL, Smith JK (1998) Multidetector-array CT: once again, technology creates new opportunities. Radiology 209:327–329PubMed
17.
go back to reference Murakami T, Kim T, Takamura M, Hori M, Takahashi S, Federle MP, Tsuda K, Osuga K, Nakamura H, Kudo M (2001) Hypervascular hepatocellular carcinoma: detection with double arterial phase multi-detector row helical CT. Radiology 218:763–767PubMed Murakami T, Kim T, Takamura M, Hori M, Takahashi S, Federle MP, Tsuda K, Osuga K, Nakamura H, Kudo M (2001) Hypervascular hepatocellular carcinoma: detection with double arterial phase multi-detector row helical CT. Radiology 218:763–767PubMed
18.
go back to reference Foley WD, Mallisee TA, Hohenwalter MD, Wilson CR, Quiroz FA, Taylor AJ (2000) Multiphase hepatic CT with a multirow detector CT scanner. AJR Am J Roentgenol 175:679–685PubMed Foley WD, Mallisee TA, Hohenwalter MD, Wilson CR, Quiroz FA, Taylor AJ (2000) Multiphase hepatic CT with a multirow detector CT scanner. AJR Am J Roentgenol 175:679–685PubMed
19.
go back to reference Wong K, Paulson EK, Nelson RC (2001) Breath-hold three-dimensional CT of the liver with multidetector helical CT. Radiology 219:75–79PubMed Wong K, Paulson EK, Nelson RC (2001) Breath-hold three-dimensional CT of the liver with multidetector helical CT. Radiology 219:75–79PubMed
20.
go back to reference National Comprehensive Cancer Network. Practice guidelines in oncology—v.1 (2005) Invasive breast cancer/clinical staging. Available at http://www.nccn. org/. Accessed 27 February 2005 National Comprehensive Cancer Network. Practice guidelines in oncology—v.1 (2005) Invasive breast cancer/clinical staging. Available at http://​www.​nccn.​ org/​. Accessed 27 February 2005
21.
go back to reference Chakraborty DP, Winter LH (1990) Free-response methodology: alternate analysis and a new observer-performance experiment. Radiology 74:873–881 Chakraborty DP, Winter LH (1990) Free-response methodology: alternate analysis and a new observer-performance experiment. Radiology 74:873–881
23.
go back to reference Rao JN, Scott AJ (1992) A simple method for the analysis of clustered binary data. Biometrics 48:577–585PubMedCrossRef Rao JN, Scott AJ (1992) A simple method for the analysis of clustered binary data. Biometrics 48:577–585PubMedCrossRef
24.
go back to reference Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174PubMedCrossRef Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174PubMedCrossRef
25.
go back to reference Bipat S, van Leeuwen MS, Comans EFI, Piji ME, Bossuyt PM, Zwinderman AH, Stoker J (2005) Colorectal liver metastases: CT, MR imaging, and PET for diagnosis-meta-analysis. Radiology 237:123–131PubMedCrossRef Bipat S, van Leeuwen MS, Comans EFI, Piji ME, Bossuyt PM, Zwinderman AH, Stoker J (2005) Colorectal liver metastases: CT, MR imaging, and PET for diagnosis-meta-analysis. Radiology 237:123–131PubMedCrossRef
26.
go back to reference Kim MJ, Kim JH, Lim JS, Oh YT, Chung JJ, Choi JS, Lee WJ, Kim KW (2004) Detection and characterization of focal hepatic lesions: mangafodipir vs. superparamagnetic iron oxide-enhanced magnetic resonance imaging. J Magn Reson Imaging 20:612–621CrossRefPubMed Kim MJ, Kim JH, Lim JS, Oh YT, Chung JJ, Choi JS, Lee WJ, Kim KW (2004) Detection and characterization of focal hepatic lesions: mangafodipir vs. superparamagnetic iron oxide-enhanced magnetic resonance imaging. J Magn Reson Imaging 20:612–621CrossRefPubMed
27.
go back to reference Ward J, Robinson PJ, Guthrie JA, Downing S, Wilson D, Lodge JP, Prasad KR, Toogood GJ, Wyatt JI (2005) Liver metastases in candidates for hepatic resection: comparison of helical CT and gadolinium- and SPIO-enhanced MR imaging. Radiology 237:170–180PubMedCrossRef Ward J, Robinson PJ, Guthrie JA, Downing S, Wilson D, Lodge JP, Prasad KR, Toogood GJ, Wyatt JI (2005) Liver metastases in candidates for hepatic resection: comparison of helical CT and gadolinium- and SPIO-enhanced MR imaging. Radiology 237:170–180PubMedCrossRef
28.
go back to reference Fretz CJ, Elizondo G, Weissleder R, Hahn PF, Stark DD, Ferrucci JT Jr (1989) Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer. Radiology 172:393–397PubMed Fretz CJ, Elizondo G, Weissleder R, Hahn PF, Stark DD, Ferrucci JT Jr (1989) Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer. Radiology 172:393–397PubMed
29.
go back to reference Kim SH, Choi D, Lim JH, Lee WJ, Jang HJ, Lim HK, Lee SJ, Cho JM, Kim SK, Kim GC (2002) Optimal pulse sequence for ferumoxides-enhanced MR imaging used in the detection of hepatocellular carcinoma: a comparative study using seven pulse sequences. Korean J Radiol 3:87–97PubMedCrossRef Kim SH, Choi D, Lim JH, Lee WJ, Jang HJ, Lim HK, Lee SJ, Cho JM, Kim SK, Kim GC (2002) Optimal pulse sequence for ferumoxides-enhanced MR imaging used in the detection of hepatocellular carcinoma: a comparative study using seven pulse sequences. Korean J Radiol 3:87–97PubMedCrossRef
30.
go back to reference Abdelmoumene A, Chevallier P, Chalaron M, Schneider F, Verdun FR, Frascarolo P, Meuli R, Schnyder P, Denys A (2005) Detection of liver metastases under 2 cm: comparison of different acquisition protocols in four row multidetector-CT (MDCT). Eur Radiol 15:1881–1887CrossRefPubMed Abdelmoumene A, Chevallier P, Chalaron M, Schneider F, Verdun FR, Frascarolo P, Meuli R, Schnyder P, Denys A (2005) Detection of liver metastases under 2 cm: comparison of different acquisition protocols in four row multidetector-CT (MDCT). Eur Radiol 15:1881–1887CrossRefPubMed
31.
go back to reference Furuta A, Ito K, Fujita T, Koike S, Shimizu A, Matsunaga N (2004) Hepatic enhancement in multiphasic contrast-enhanced MDCT: comparison of high- and low-iodine-concentration contrast medium in same patients with chronic liver disease. AJR Am J Roentgenol 183:157–162PubMed Furuta A, Ito K, Fujita T, Koike S, Shimizu A, Matsunaga N (2004) Hepatic enhancement in multiphasic contrast-enhanced MDCT: comparison of high- and low-iodine-concentration contrast medium in same patients with chronic liver disease. AJR Am J Roentgenol 183:157–162PubMed
32.
go back to reference Yagyu Y, Awai K, Inoue M, Watai R, Sano T, Hasegawa H, Nishimura Y (2005) MDCT of hypervascular hepatocellular carcinomas: a prospective study using contrast materials with different iodine concentrations. AJR Am J Roentgenol 184:1535–1540PubMed Yagyu Y, Awai K, Inoue M, Watai R, Sano T, Hasegawa H, Nishimura Y (2005) MDCT of hypervascular hepatocellular carcinomas: a prospective study using contrast materials with different iodine concentrations. AJR Am J Roentgenol 184:1535–1540PubMed
33.
go back to reference Sica GT, Ji H, Ros PR (2000) CT and MR imaging of hepatic metastases. AJR Am J Roentgenol 174:691–698PubMed Sica GT, Ji H, Ros PR (2000) CT and MR imaging of hepatic metastases. AJR Am J Roentgenol 174:691–698PubMed
34.
go back to reference Urban BA, Fishman EK, Kuhlman JE, Kawashima A, Hennessey JG, Siegelman SS (1993) Detection of focal hepatic lesions with spiral CT: comparison of 4- and 8-mm interscan spacing. AJR Am J Roentgenol 160:783–785PubMed Urban BA, Fishman EK, Kuhlman JE, Kawashima A, Hennessey JG, Siegelman SS (1993) Detection of focal hepatic lesions with spiral CT: comparison of 4- and 8-mm interscan spacing. AJR Am J Roentgenol 160:783–785PubMed
35.
go back to reference Obuchowski NA (2003) Receiver operating characteristic curves and their use in radiology. Radiology 229:3–8PubMedCrossRef Obuchowski NA (2003) Receiver operating characteristic curves and their use in radiology. Radiology 229:3–8PubMedCrossRef
36.
go back to reference Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39:561–577PubMed Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39:561–577PubMed
Metadata
Title
Detection and characterization of liver metastases: 16--slice multidetector computed tomography versus superparamagnetic iron oxide-enhanced magnetic resonance imaging
Authors
Young Kon Kim
Seog Wan Ko
Seung Bae Hwang
Chong Soo Kim
Hee Chul Yu
Publication date
01-06-2006
Publisher
Springer-Verlag
Published in
European Radiology / Issue 6/2006
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-005-0140-y

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