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01-07-2004 | Experimental

3D pulmonary perfusion MRI and MR angiography of pulmonary embolism in pigs after a single injection of a blood pool MR contrast agent

Authors: Christian Fink, Sebastian Ley, Michael Puderbach, Christian Plathow, Michael Bock, Hans-Ulrich Kauczor

Published in: European Radiology | Issue 7/2004

Abstract

The purpose of this study was to assess the feasibility of contrast-enhanced 3D perfusion MRI and MR angiography (MRA) of pulmonary embolism (PE) in pigs using a single injection of the blood pool contrast Gadomer. PE was induced in five domestic pigs by injection of autologous blood thrombi. Contrast-enhanced first-pass 3D perfusion MRI (TE/TR/FA: 1.0 ms/2.2 ms/40°; voxel size: 1.3×2.5×4.0 mm³; TA: 1.8 s per data set) and high-resolution 3D MRA (TE/TR/FA: 1.4 ms/3.4 ms/40°; voxel size: 0.8×1.0×1.6 mm³) was performed during and after a single injection of 0.1 mmol/kg body weight of Gadomer. Image data were compared to pre-embolism Gd-DTPA-enhanced MRI and post-embolism thin-section multislice CT (n=2). SNR measurements were performed in the pulmonary arteries and lung. One animal died after induction of PE. In all other animals, perfusion MRI and MRA could be acquired after a single injection of Gadomer. At perfusion MRI, PE could be detected by typical wedge-shaped perfusion defects. While the visualization of central PE at MRA correlated well with the CT, peripheral PE were only visualized by CT. Gadomer achieved a higher peak SNR of the lungs compared to Gd-DTPA (21±8 vs. 13±3). Contrast-enhanced 3D perfusion MRI and MRA of PE can be combined using a single injection of the blood pool contrast agent Gadomer.

van Strijen MJ, de Monye W, Schiereck J, Kieft GJ, Prins MH, Huisman MV, Pattynama PM (2003) Single-detector helical computed tomography as the primary diagnostic test in suspected pulmonary embolism: a multicenter clinical management study of 510 patients. Ann Int Med 138:307–314PubMed

Enzweiler CN, Lembcke AE, Wiese TH, Grohmann A, Rogalla P, Bollow M, Kopka L, Hamm B (2002) Häufigkeit und Verteilungsmuster pulmonaler Sattelembolien: Diagnostik mittels Elektronenstrahl-Computertomographie (EBT). Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 174:862–866CrossRefPubMed

van Strijen MJ, de Monye W, Kieft GJ, Pattynama PM, Huisman MV, Smith SJ, Bloem JL (2003) Diagnosis of pulmonary embolism with spiral CT as a second procedure following scintigraphy. Eur Radiol 13:1501–1507CrossRefPubMed

Oudkerk M, van Beek EJ, Wielopolski P, van Ooijen PM, Brouwers-Kuyper EM, Bongaerts AH, Berghout A (2002) Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. Lancet 359:1643–1647CrossRefPubMed

Meaney JF, Weg JG, Chenevert TL, Stafford-Johnson D, Hamilton BH, Prince MR (1997) Diagnosis of pulmonary embolism with magnetic resonance angiography. N Engl J Med 336:1422–1427

Hatabu H, Gaa J, Kim D, Li W, Prasad PV, Edelman RR (1996) Pulmonary perfusion: qualitative assessment with dynamic contrast-enhanced MRI using ultra-short TE and inversion recovery turbo FLASH. Magn Reson Med 36:503–508PubMed

Howarth NR, Beziat C, Berthezene Y (1999) Evolution of pulmonary perfusion defects demonstrated with contrast-enhanced dynamic MR perfusion imaging. Eur Radiol 9:1574–1576CrossRefPubMed

Fink C, Bock M, Puderbach M, Schmahl A, Delorme S (2003) Partially parallel three-dimensional magnetic resonance imaging for the assessment of lung perfusion—initial results. Invest Radiol 38:482–488CrossRefPubMed

Berthezene Y, Croisille P, Wiart M, Howarth N, Houzard C, Faure O, Douek P, Amiel M, Revel D (1999) Prospective comparison of MR lung perfusion and lung scintigraphy. J Magn Reson Imaging 9:61–68CrossRefPubMed

10.

Amundsen T, Torheim G, Kvistad KA, Waage A, Bjermer L, Nordlid KK, Johnsen H, Asberg A, Haraldseth O (2002) Perfusion abnormalities in pulmonary embolism studied with perfusion MRI and ventilation-perfusion scintigraphy: an intra-modality and inter-modality agreement study. J Magn Reson Imaging 15:386–394CrossRefPubMed

11.

Schnorr J, Wagner S, Ebert W, Heyer C, Laub G, Kivelitz D, Abramjuk C, Hamm B, Taupitz M (2003) MR-Angiographie der Koronararterien: Vergleich des Blutpoolkontrastmittels Gadomer mit Gd-DTPA am Schwein. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 175:822–829CrossRefPubMed

12.

Abolmaali ND, Hietschold V, Appold S, Ebert W, Vogl TJ (2002) Gadomer-17-enhanced 3D navigator-echo MR angiography of the pulmonary arteries in pigs. Eur Radiol 12:692–697PubMed

13.

Stanford W, Reiners TJ, Thompson BH, Landas SK, Galvin JR (1994) Contrast-enhanced thin slice ultrafast computed tomography for the detection of small pulmonary emboli. Studies using autologous emboli in the pig. Invest Radiol 29:184–187PubMed

14.

Misselwitz B, Schmitt-Willich H, Ebert W, Frenzel T, Weinmann HJ (2001) Pharmacokinetics of Gadomer-17, a new dendritic magnetic resonance contrast agent. MAGMA 12:128–134PubMed

15.

Griswold MA, Jakob PM, Heidemann RM, Nittka M, Jellus V, Wang J, Kiefer B, Haase A (2002) Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 47:1202–1210CrossRefPubMed

16.

Sodickson DK, Manning WJ (1997) Simultaneous acquisition of spatial harmonics (SMASH): fast imaging with radiofrequency coil arrays. Magn Reson Med 38:591–603PubMed

17.

Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P (1999) SENSE: sensitivity encoding for fast MRI. Magn Reson Med 42:952–962CrossRefPubMed

18.

Hunold P, Maderwald S, Ladd ME et al (2002) Parallel acquisition techniques for cardiac cine MRA: comparison of image quality. Proc ISMRM 2002:1664

19.

Berthezene Y, Vexler V, Price DC, Wisner-Dupon J, Moseley ME, Aicher KP, Brasch RC (1992) Magnetic resonance imaging detection of an experimental pulmonary perfusion deficit using a macromolecular contrast agent. Polylysine-gadolinium-DTPA40. Invest Radiol 27:346–351PubMed

20.

Zheng J, Carr J, Harris K, Saker MB, Cavagna FM, Maggioni F, Laub G, Li D, Finn JP (2001) Three-dimensional MR pulmonary perfusion imaging and angiography with an injection of a new blood pool contrast agent B-22956/1. J Magn Reson Imaging 14:425–432PubMed

21.

Kauczor HU, Hanke A, Van Beek EJ (2002) Assessment of lung ventilation by MR imaging: current status and future perspectives. Eur Radiol 12:1962–1970PubMed

Title: 3D pulmonary perfusion MRI and MR angiography of pulmonary embolism in pigs after a single injection of a blood pool MR contrast agent
Authors: Christian Fink
Sebastian Ley
Michael Puderbach
Christian Plathow
Michael Bock
Hans-Ulrich Kauczor
Publication date: 01-07-2004
Publisher: Springer-Verlag
Published in: European Radiology / Issue 7/2004
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-004-2282-8

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3D pulmonary perfusion MRI and MR angiography of pulmonary embolism in pigs after a single injection of a blood pool MR contrast agent

Abstract

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Abstract

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