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Published in: European Radiology 4/2004

01-04-2004 | Neuro

Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease

Authors: Volker Hesselmann, Bettina Sorger, Ralf Girnus, Kathrin Lasek, Mohammad Maarouf, Christoph Wedekind, Jürgen Bunke, Oliver Schulte, Barbara Krug, Klaus Lackner, Volker Sturm

Published in: European Radiology | Issue 4/2004

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Abstract

This article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS.
Literature
1.
go back to reference Fried I, Nenov VI, Ojemann SG, Woods RP (1995) Functional MR and PET imaging of rolandic and visual cortices for neurosurgical planning. J Neurosurg 83:854–961PubMed Fried I, Nenov VI, Ojemann SG, Woods RP (1995) Functional MR and PET imaging of rolandic and visual cortices for neurosurgical planning. J Neurosurg 83:854–961PubMed
2.
go back to reference Nitschke MF, Melchert UH, Hahn C, Otto V, Arnold H, Herrmann HD, Nowak G, Westphal M, Wessel K (1998) Preoperative functional magnetic resonance imaging (fMRI) of the motor system in patients with tumors in the parietal lobe. Acta Neurochir 140:1223–1229CrossRef Nitschke MF, Melchert UH, Hahn C, Otto V, Arnold H, Herrmann HD, Nowak G, Westphal M, Wessel K (1998) Preoperative functional magnetic resonance imaging (fMRI) of the motor system in patients with tumors in the parietal lobe. Acta Neurochir 140:1223–1229CrossRef
3.
go back to reference Achten E, Jackson GD, Cameron JA, Abbott DF, Stella DL, Fabinyi GC (1999) Presurgical evaluation of the motor hand area with functional MR imaging in patients with tumors and dysplastic lesions. Radiology 210:529–538PubMed Achten E, Jackson GD, Cameron JA, Abbott DF, Stella DL, Fabinyi GC (1999) Presurgical evaluation of the motor hand area with functional MR imaging in patients with tumors and dysplastic lesions. Radiology 210:529–538PubMed
4.
go back to reference Tomczak RJ, Wunderlich AP, Wang Y, Braun V, Antoniadis G, Gorich J, Richter HP, Brambs HJ (2000) fMRI for preoperative neurosurgical mapping of motor cortex and language in a clinical setting. J Comput Assist Tomogr 24:927–934CrossRefPubMed Tomczak RJ, Wunderlich AP, Wang Y, Braun V, Antoniadis G, Gorich J, Richter HP, Brambs HJ (2000) fMRI for preoperative neurosurgical mapping of motor cortex and language in a clinical setting. J Comput Assist Tomogr 24:927–934CrossRefPubMed
5.
go back to reference Hall WA, Liu H, Martin A, Pozza CH, Maxwell RE, Truwit CL (2000) Safety, efficacy and functionality of high field strength interventional magnetic resonance imaging for neurosurgery. Neurosurgery 46:632–641PubMed Hall WA, Liu H, Martin A, Pozza CH, Maxwell RE, Truwit CL (2000) Safety, efficacy and functionality of high field strength interventional magnetic resonance imaging for neurosurgery. Neurosurgery 46:632–641PubMed
6.
7.
go back to reference Alexander GE, Crutcher MD, DeLong MR (1990) Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res 85:119–146PubMed Alexander GE, Crutcher MD, DeLong MR (1990) Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res 85:119–146PubMed
8.
go back to reference Volkmann J, Loliot M, Molgilner A, Ioannides AA, Lado F, Fazzini E, Ribary U, Llinas R (1996) Central motor loop oscillations in Parkinsonian resting tremor revealed by magnetoencephalography. Neurology 46:1359–1370PubMed Volkmann J, Loliot M, Molgilner A, Ioannides AA, Lado F, Fazzini E, Ribary U, Llinas R (1996) Central motor loop oscillations in Parkinsonian resting tremor revealed by magnetoencephalography. Neurology 46:1359–1370PubMed
9.
go back to reference Volkmann J, Sturm V, Weiss P, Kappler P, Voges J, Koulousakis A, Lehrke R, Hefter H, Freund HJ (1998) Bilateral high frequency stimulation of the internal globus pallidus in advanced Parkinson's disease. Ann Neurol 44:953–961PubMed Volkmann J, Sturm V, Weiss P, Kappler P, Voges J, Koulousakis A, Lehrke R, Hefter H, Freund HJ (1998) Bilateral high frequency stimulation of the internal globus pallidus in advanced Parkinson's disease. Ann Neurol 44:953–961PubMed
10.
go back to reference Rezai AR, Lozano AM, Crawley AP, Joy ML, Davis KD, Kwan CL, Dostrovsky JO, Tasker RR, Mikulis DJ (1999) Thalamic stimulation and functional magnetic resonance imaging: localization of cortical and subcortical activation with implanted electrodes. Technical note. Neurology 46:583–590 Rezai AR, Lozano AM, Crawley AP, Joy ML, Davis KD, Kwan CL, Dostrovsky JO, Tasker RR, Mikulis DJ (1999) Thalamic stimulation and functional magnetic resonance imaging: localization of cortical and subcortical activation with implanted electrodes. Technical note. Neurology 46:583–590
11.
go back to reference Sabatini U, Boulanouar K, Fabre N, Martin F, Carel C, Colonnese C, Bozzao L, Berry I, Montrastruc JL, Chollet F, Rascol O (2000) Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study. Brain 123:394–403PubMed Sabatini U, Boulanouar K, Fabre N, Martin F, Carel C, Colonnese C, Bozzao L, Berry I, Montrastruc JL, Chollet F, Rascol O (2000) Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study. Brain 123:394–403PubMed
12.
go back to reference Girnus R, Hesselmann V, Luyken KJ, Krug B, Nimtz G, Lackner K (2002) Interventional MRI in patients with implanted deep brain stimulation electrodes: safety aspects. Proc Int Soc Magn Reson Med 10:2242 Girnus R, Hesselmann V, Luyken KJ, Krug B, Nimtz G, Lackner K (2002) Interventional MRI in patients with implanted deep brain stimulation electrodes: safety aspects. Proc Int Soc Magn Reson Med 10:2242
13.
go back to reference Haslinger B, Erhard P, Kämpfe N, Boecker H, Rummeny E, Schwaiger M, Conrad B, Ceballos-Baumann O (2001) Event related functional magnetic resonance imaging in Parkinson' s disease before and after Levodopa. Brain 124:558–570CrossRefPubMed Haslinger B, Erhard P, Kämpfe N, Boecker H, Rummeny E, Schwaiger M, Conrad B, Ceballos-Baumann O (2001) Event related functional magnetic resonance imaging in Parkinson' s disease before and after Levodopa. Brain 124:558–570CrossRefPubMed
14.
go back to reference Ceballos-Baumann AO, Boecker H, Bartenstein P, Falkenhain I von, Riescher H, Conrad B, Moringlane JR, Alesch F (1999) A positron emission tomographic study of subthalamic nucleus stimulation in Parkinson disease: enhanced movement-related activity of motor association cortex and decreased motor cortex resting activity. Arch Neurol 56:997–1003PubMed Ceballos-Baumann AO, Boecker H, Bartenstein P, Falkenhain I von, Riescher H, Conrad B, Moringlane JR, Alesch F (1999) A positron emission tomographic study of subthalamic nucleus stimulation in Parkinson disease: enhanced movement-related activity of motor association cortex and decreased motor cortex resting activity. Arch Neurol 56:997–1003PubMed
15.
go back to reference Limousin P, Greene J, Polak P, Rothwell JC, Benabid AL, Frackowiack RSJ (1997) Positron emission tomography (PET) study of modulation of cerebral activity by subthalamic nucleus (STN) and internal globus pallidus (GPI) stimulation in Parkinson's disease. Neurology 48 (Suppl 2):A249 Limousin P, Greene J, Polak P, Rothwell JC, Benabid AL, Frackowiack RSJ (1997) Positron emission tomography (PET) study of modulation of cerebral activity by subthalamic nucleus (STN) and internal globus pallidus (GPI) stimulation in Parkinson's disease. Neurology 48 (Suppl 2):A249
16.
go back to reference Jech R, Urgosik D, Tintera J, Nebuzelsky A, Krasensky J, Liscak R, Roth J, Ruzicka E (2001) Functional magnetic resonance imaging during deep brain stimulation: a pilot study in four patients with Parkinson's disease. Mov Disord 16:1126–1132CrossRefPubMed Jech R, Urgosik D, Tintera J, Nebuzelsky A, Krasensky J, Liscak R, Roth J, Ruzicka E (2001) Functional magnetic resonance imaging during deep brain stimulation: a pilot study in four patients with Parkinson's disease. Mov Disord 16:1126–1132CrossRefPubMed
17.
go back to reference Parrish TB, Gitelmann DR, LaBar KS, Marsel-Mesulam M (2000) Impact of signal-to-noise-ratio on functional MRI. Magn Reson Med 44:925–932CrossRefPubMed Parrish TB, Gitelmann DR, LaBar KS, Marsel-Mesulam M (2000) Impact of signal-to-noise-ratio on functional MRI. Magn Reson Med 44:925–932CrossRefPubMed
18.
go back to reference Ball T, Schreiber A, Feige B, Wagner M, Lucking CH, Kristeva-Feige R (1999) The role of higher-order motor areas in voluntary movement as revealed by high-resolution EEG and fMRI. Neuroimage 10:682–694PubMed Ball T, Schreiber A, Feige B, Wagner M, Lucking CH, Kristeva-Feige R (1999) The role of higher-order motor areas in voluntary movement as revealed by high-resolution EEG and fMRI. Neuroimage 10:682–694PubMed
Metadata
Title
Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease
Authors
Volker Hesselmann
Bettina Sorger
Ralf Girnus
Kathrin Lasek
Mohammad Maarouf
Christoph Wedekind
Jürgen Bunke
Oliver Schulte
Barbara Krug
Klaus Lackner
Volker Sturm
Publication date
01-04-2004
Publisher
Springer-Verlag
Published in
European Radiology / Issue 4/2004
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-003-2051-0

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