Published in:
01-04-2004 | Neuro
Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease
Authors:
Volker Hesselmann, Bettina Sorger, Ralf Girnus, Kathrin Lasek, Mohammad Maarouf, Christoph Wedekind, Jürgen Bunke, Oliver Schulte, Barbara Krug, Klaus Lackner, Volker Sturm
Published in:
European Radiology
|
Issue 4/2004
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Abstract
This article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS.