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01-01-2004 | Hepatobiliary–Pancreas

Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT

Authors: Carlo Bartolozzi, Francescamaria Donati, Dania Cioni, Carlo Procacci, Giovanni Morana, Antonio Chiesa, Luigi Grazioli, Giorgio Cittadini, Giuseppe Cittadini, Andrea Giovagnoni, Giovanni Gandini, Jochen Maass, Riccardo Lencioni

Published in: European Radiology | Issue 1/2004

Abstract

The aim of this study was to compare unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT in the detection of hepatic colorectal metastases. Forty-four patients with hepatic colorectal metastases were examined with unenhanced and MnDPDP-enhanced MRI and with unenhanced and contrast-enhanced spiral CT. The MR examination protocol included baseline T1-weighted spin-echo (SE), T1-weighted gradient-recalled-echo (GRE), and T2-weighted fast-SE sequences; and T1-weighted SE and T1-weighted GRE sequences obtained 30–60 min after administration of 0.5 µmol/kg (0.5 ml/kg) mangafodipir trisodium (MnDPDP). Images were interpreted by three blinded readers. Findings at CT and MRI were compared with those at intraoperative US, which were used as term of reference. Intraoperative US detected 128 metastases. In a lesion-by-lesion analysis, the overall detection rate was 71% (91 of 128) for spiral CT, 72% (92 of 128) for unenhanced MRI, and 90% (115 of 128) for MnDPDP-enhanced MRI. MnDPDP-enhanced MRI was more sensitive than either unenhanced MRI (p<0.0001) or spiral CT (p=0.0007). In a patient-by-patient analysis, agreement with gold standard was higher for MnDPDP-enhanced MRI (33 of 44 cases) than for spiral CT (22 of 44 cases, p=0.0023) and unenhanced MRI (21 of 44 cases, p=0.0013). MnDPDP-enhanced MRI is superior to unenhanced MRI and spiral CT in the detection of hepatic colorectal metastases.

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Title: Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT
Authors: Carlo Bartolozzi
Francescamaria Donati
Dania Cioni
Carlo Procacci
Giovanni Morana
Antonio Chiesa
Luigi Grazioli
Giorgio Cittadini
Giuseppe Cittadini
Andrea Giovagnoni
Giovanni Gandini
Jochen Maass
Riccardo Lencioni
Publication date: 01-01-2004
Publisher: Springer-Verlag
Published in: European Radiology / Issue 1/2004
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-003-1966-9

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Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT

Abstract

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Springer Medicine

Abstract

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