Skip to main content
Top
Published in: European Radiology 9/2003

01-09-2003 | Hepatobiliary–Pancreas

Effect of contrast injection protocol with dose tailored to patient weight and fixed injection duration on aortic and hepatic enhancement at multidetector-row helical CT

Authors: Kazuo Awai, Shinichi Hori

Published in: European Radiology | Issue 9/2003

Login to get access

Abstract

The aim of this study was to investigate the effect of a contrast material injection protocol with dose and injection rate of contrast material tailored to patient weight (dose tailored to patient weight and fixed injection duration). Hepatic helical CT was performed in 92 patients with chronic liver damage with a dose of 1.4 ml (518 mgI) at a rate of 0.056 ml/s per kilogram body weight of Iopamidol 370. Attenuation values of liver and aorta were measured for calculation of maximum aortic and hepatic enhancement, time to maximum hepatic enhancement, and end of hepatic arterial phase. Correlation coefficients between the injection rate and the four parameters were r=0.008, 0.057, 0.167, and 0.036, and there were no statistically significant correlations between the injection rates and the four parameters. In our injection protocol, uniform temporal scan window may be achieved and the injection rate can be reduced in lighter patients without reducing the degree of enhancement in the aorta and the liver.
Literature
1.
go back to reference Bonaldi VM, Bret PM, Reinhold C, Atri M (1995) Helical CT of the liver: value of an early hepatic arterial phase. Radiology 197:357PubMedCrossRef Bonaldi VM, Bret PM, Reinhold C, Atri M (1995) Helical CT of the liver: value of an early hepatic arterial phase. Radiology 197:357PubMedCrossRef
2.
go back to reference Oliver JH III, Baron RL (1996) Helical biphasic contrast enhanced CT of the liver: technique, indications, interpretations, and pitfalls. Radiology 201:1PubMedCrossRef Oliver JH III, Baron RL (1996) Helical biphasic contrast enhanced CT of the liver: technique, indications, interpretations, and pitfalls. Radiology 201:1PubMedCrossRef
3.
go back to reference Mitsuzaki K, Yamashita Y, Ogata I, Nishiharu T, Urata J, Takahashi M (1996) Multiple-phase helical CT of the liver for detecting small hepatomas in patients with liver cirrhosis: contrast-injection protocol and optimal timing. AJR 167:753PubMedCrossRef Mitsuzaki K, Yamashita Y, Ogata I, Nishiharu T, Urata J, Takahashi M (1996) Multiple-phase helical CT of the liver for detecting small hepatomas in patients with liver cirrhosis: contrast-injection protocol and optimal timing. AJR 167:753PubMedCrossRef
4.
go back to reference Foley WD, Hoffmann RG, Quiroz FA, Kahn CE, Perret RS (1994) Hepatic helical CT: contrast material injection protocol. Radiology 192:367PubMedCrossRef Foley WD, Hoffmann RG, Quiroz FA, Kahn CE, Perret RS (1994) Hepatic helical CT: contrast material injection protocol. Radiology 192:367PubMedCrossRef
5.
go back to reference Hollete MD, Jeffrey RB Jr, Nino-Murcia M, Jorgensen MJ, Harris DP (1995) Dual-phase helical CT of the liver: value of arterial phase scans in the detection of small (≤1.5 cm) malignant hepatic neoplasms. AJR 164:879CrossRef Hollete MD, Jeffrey RB Jr, Nino-Murcia M, Jorgensen MJ, Harris DP (1995) Dual-phase helical CT of the liver: value of arterial phase scans in the detection of small (≤1.5 cm) malignant hepatic neoplasms. AJR 164:879CrossRef
6.
go back to reference Kopka L, Funke M, Fischer U, Vosshenrich R, Oestmann JW, Grabbe E (1995) Parenchymal liver enhancement with bolus-triggered helical CT: preliminary clinical results. Radiology 195:282PubMedCrossRef Kopka L, Funke M, Fischer U, Vosshenrich R, Oestmann JW, Grabbe E (1995) Parenchymal liver enhancement with bolus-triggered helical CT: preliminary clinical results. Radiology 195:282PubMedCrossRef
7.
go back to reference Silverman PM, O'Malley J, Tefft MC, Cooper C, Zeman R (1995) Conspicuity of heptatic metastases on helical CT: effect of different time delays between contrast administration and scanning. AJR 164:619PubMedCrossRef Silverman PM, O'Malley J, Tefft MC, Cooper C, Zeman R (1995) Conspicuity of heptatic metastases on helical CT: effect of different time delays between contrast administration and scanning. AJR 164:619PubMedCrossRef
8.
go back to reference Heiken JP, Brink JA, McClennan BL, Sagel SS, Crowe TM, Gaines MV (1995) Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancement. Radiology 195:353PubMedCrossRef Heiken JP, Brink JA, McClennan BL, Sagel SS, Crowe TM, Gaines MV (1995) Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancement. Radiology 195:353PubMedCrossRef
9.
go back to reference Brink JA, Heiken JP, Forman HP, Sagel SS, Molina PL, Brown PC (1995) Hepatic spiral CT: reduction of dose of intravenous contrast material. Radiology 197:83PubMedCrossRef Brink JA, Heiken JP, Forman HP, Sagel SS, Molina PL, Brown PC (1995) Hepatic spiral CT: reduction of dose of intravenous contrast material. Radiology 197:83PubMedCrossRef
10.
go back to reference Dean PB, Violante MR, Mahoney JA (1980) Hepatic CT contrast enhancement: effect of dose, duration of infusion, and time elapsed following infusion. Invest Radiol 15:158PubMedCrossRef Dean PB, Violante MR, Mahoney JA (1980) Hepatic CT contrast enhancement: effect of dose, duration of infusion, and time elapsed following infusion. Invest Radiol 15:158PubMedCrossRef
11.
go back to reference Berland LL, Lee JY (1988) Comparison of contrast media injection rates and volumes for hepatic dynamic incremented computed tomography. Invest Radiol 23:918PubMedCrossRef Berland LL, Lee JY (1988) Comparison of contrast media injection rates and volumes for hepatic dynamic incremented computed tomography. Invest Radiol 23:918PubMedCrossRef
12.
go back to reference Harmon BH, Berland LL, Lee JY (1992) Effect of varying rates of low-osmolarity contrast media injection for hepatic CT: correlation with indocyanine green transit time. Radiology 184:379PubMedCrossRef Harmon BH, Berland LL, Lee JY (1992) Effect of varying rates of low-osmolarity contrast media injection for hepatic CT: correlation with indocyanine green transit time. Radiology 184:379PubMedCrossRef
13.
go back to reference Heiken JP, Brink JA, McClennan BL, Sagel SS, Forman HP, DiCroce J (1993) Dynamic contrast-enhanced CT of the liver: comparison of contrast medium injection rates and uniphasic and biphasic injection protocols. Radiology 187:327PubMedCrossRef Heiken JP, Brink JA, McClennan BL, Sagel SS, Forman HP, DiCroce J (1993) Dynamic contrast-enhanced CT of the liver: comparison of contrast medium injection rates and uniphasic and biphasic injection protocols. Radiology 187:327PubMedCrossRef
14.
go back to reference Garcia PA, Bonaldi VM, Bret PM, Liang L, Reinhold C, Atri M (1996) Effect of rate of contrast medium injection on hepatic enhancement at CT. Radiology 199:185PubMedCrossRef Garcia PA, Bonaldi VM, Bret PM, Liang L, Reinhold C, Atri M (1996) Effect of rate of contrast medium injection on hepatic enhancement at CT. Radiology 199:185PubMedCrossRef
15.
go back to reference Bae KT, Heiken JP, Brink JA (1998) Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate pharmacokinetic analysis and experimental porcine model. Radiology 206:455PubMedCrossRef Bae KT, Heiken JP, Brink JA (1998) Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate pharmacokinetic analysis and experimental porcine model. Radiology 206:455PubMedCrossRef
16.
go back to reference Kim T, Murakami T, Takahashi S et al. (1998) Effect of injection rates of contrast material on arterial phase hepatic CT. AJR 171:429PubMedCrossRef Kim T, Murakami T, Takahashi S et al. (1998) Effect of injection rates of contrast material on arterial phase hepatic CT. AJR 171:429PubMedCrossRef
17.
go back to reference Itoh S, Ikeda M, Achiwa M, Ota T, Satake H, Ishigaki T (2003) Multiphase contrast-enhanced CT of the liver with a multislice CT scanner. Eur Radiol 13:1085 Itoh S, Ikeda M, Achiwa M, Ota T, Satake H, Ishigaki T (2003) Multiphase contrast-enhanced CT of the liver with a multislice CT scanner. Eur Radiol 13:1085
18.
go back to reference Kopp AF, Heuschmid M, Claussen CD (2002) Multidetector helical CT of the liver for tumor detection and characterization. Eur Radiol 12:745PubMedCrossRef Kopp AF, Heuschmid M, Claussen CD (2002) Multidetector helical CT of the liver for tumor detection and characterization. Eur Radiol 12:745PubMedCrossRef
19.
go back to reference Sandstede JJ, Tshammler A, Beer M, Vogelsang C, Wittenberg G, Hahn D (2001) Optimization of automatic bolus tracking for timing of the arterial phase of helical liver CT. Eur Radiol 11:1396PubMedCrossRef Sandstede JJ, Tshammler A, Beer M, Vogelsang C, Wittenberg G, Hahn D (2001) Optimization of automatic bolus tracking for timing of the arterial phase of helical liver CT. Eur Radiol 11:1396PubMedCrossRef
20.
go back to reference Yamashita Y, Komohara Y, Takahashi M, Uchida M, Hayabuchi N, Shimizu T, Narabayashi I (2000) Abdominal helical CT: evaluation of optimal doses of intravenous contrast material. A prospective randomized study. Radiology 216:718PubMedCrossRef Yamashita Y, Komohara Y, Takahashi M, Uchida M, Hayabuchi N, Shimizu T, Narabayashi I (2000) Abdominal helical CT: evaluation of optimal doses of intravenous contrast material. A prospective randomized study. Radiology 216:718PubMedCrossRef
21.
go back to reference Murakami T, Kim T, Takamura M et al. (2001) Hypervascular hepatocellular carcianoma: detection with double arterial phase multi-detector row helical CT. Radiology 218:763PubMedCrossRef Murakami T, Kim T, Takamura M et al. (2001) Hypervascular hepatocellular carcianoma: detection with double arterial phase multi-detector row helical CT. Radiology 218:763PubMedCrossRef
22.
go back to reference Foley WD, Mallisee TA, Hohenwalter MD, Wilson CR, Quiroz FA, Taylor AJ (2000) Multiphase hepatic CT with a multirow detector CT scanner. AJR 175:679PubMedCrossRef Foley WD, Mallisee TA, Hohenwalter MD, Wilson CR, Quiroz FA, Taylor AJ (2000) Multiphase hepatic CT with a multirow detector CT scanner. AJR 175:679PubMedCrossRef
23.
go back to reference Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K (1990) Adverse reactions to ionic and nonionic contrast media. A report from the Japanese committee on the safety of contrast media. Radiology 175:621PubMedCrossRef Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K (1990) Adverse reactions to ionic and nonionic contrast media. A report from the Japanese committee on the safety of contrast media. Radiology 175:621PubMedCrossRef
Metadata
Title
Effect of contrast injection protocol with dose tailored to patient weight and fixed injection duration on aortic and hepatic enhancement at multidetector-row helical CT
Authors
Kazuo Awai
Shinichi Hori
Publication date
01-09-2003
Publisher
Springer-Verlag
Published in
European Radiology / Issue 9/2003
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-003-1904-x

Other articles of this Issue 9/2003

European Radiology 9/2003 Go to the issue