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European Radiology
Published in: European Radiology 9/2003

01-09-2003 | Vascular–Interventional

Gadobutrol-enhanced moving-table magnetic resonance angiography in patients with peripheral vascular disease: a prospective, multi-centre blinded comparison with digital subtraction angiography

Authors: Annette Hentsch, Manuela A. Aschauer, Jörn O. Balzer, Joachim Brossmann, Hans P. Busch, Kirsten Davis, Philippe Douek, Franz Ebner, Jos M. A. van Engelshoven, Michaela Gregor, Christian Kersting, Patrick R. Knüsel, Edward Leen, Tim Leiner, Christian Loewe, Simon McPherson, Peter Reimer, Fritz K. W. Schäfer, Matthias Taupitz, Siegfried A. Thurnher, Bernd Tombach, Robin Wegener, Dominik Weishaupt, James F. M. Meaney

Published in: European Radiology | Issue 9/2003

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Abstract.

The purpose of this study was to compare moving-table three-dimensional contrast-enhanced magnetic resonance angiography (CE MRA), using 1.0-mol gadobutrol, with intra-arterial digital subtraction angiography (i.a. DSA) for evaluation of pelvic and peripheral arteries in patients with peripheral arterial occlusive disease. A total of 203 patients were examined in a prospective, multi-centre study at 1.0/1.5 T. Ten vessel segments of one leg were evaluated on-site and by three independent blinded reviewers off-site. One hundred eighty-two patients were evaluable in blinded reading. For pelvis and thigh, there was statistically significant diagnostic agreement between CE MRA and i.a. DSA on-site (94%) and off-site (86–88%). Overall, for detection of clinically significant stenoses, 93% sensitivity and 90% specificity were achieved in on-site evaluation, with 71–76 and 87–93% off-site; for detection of occlusion, sensitivity and specificity on-site were 91 and 97%, with 75–82 and 94–98% off-site. Evaluation was more sensitive on-site than off-site for detection of stenoses and occlusion, whereas specificity was similar. The CE MRA with 1.0-mol gadobutrol gave results comparable to those of i.a. DSA for the larger arteries of pelvis and thigh. Results for calf arteries were compromised by spatial resolution and technical limitations.
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Metadata
Title
Gadobutrol-enhanced moving-table magnetic resonance angiography in patients with peripheral vascular disease: a prospective, multi-centre blinded comparison with digital subtraction angiography
Authors
Annette Hentsch
Manuela A. Aschauer
Jörn O. Balzer
Joachim Brossmann
Hans P. Busch
Kirsten Davis
Philippe Douek
Franz Ebner
Jos M. A. van Engelshoven
Michaela Gregor
Christian Kersting
Patrick R. Knüsel
Edward Leen
Tim Leiner
Christian Loewe
Simon McPherson
Peter Reimer
Fritz K. W. Schäfer
Matthias Taupitz
Siegfried A. Thurnher
Bernd Tombach
Robin Wegener
Dominik Weishaupt
James F. M. Meaney
Publication date
01-09-2003
Publisher
Springer-Verlag
Published in
European Radiology / Issue 9/2003
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-003-1844-5

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