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Published in: Rheumatology International 11/2010

01-09-2010 | Review

Atherosclerosis and endothelial dysfunction in patients with ankylosing spondylitis

Authors: V. F. Azevedo, R. Pecoits-Filho

Published in: Rheumatology International | Issue 11/2010

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Abstract

Ankylosing spondylitis (AS) is a systemic inflammatory rheumatic disease characterized primarily by axial joint involvement, sacroiliitis and various extra-articular manifestations. High cardiovascular mortality in AS has led many researchers to investigate possible risk factors involved with cardiovascular disease in these patients. This review summarizes published data concerning endothelial dysfunction and atherosclerosis in patients with AS. The author discusses current limitations and problems related to a better assessment of these two possible changes in AS.
Literature
1.
go back to reference Peters MJ, van der Horst-Bruinsma IE, Dijkmans BA, Nurmohamed MT (2004) Cardiovascular risk profile of patients with spondylarthropathies, particularly ankylosing spondylitis and psoriatic arthritis. Semin Arthritis Rheum 34:585–592CrossRefPubMed Peters MJ, van der Horst-Bruinsma IE, Dijkmans BA, Nurmohamed MT (2004) Cardiovascular risk profile of patients with spondylarthropathies, particularly ankylosing spondylitis and psoriatic arthritis. Semin Arthritis Rheum 34:585–592CrossRefPubMed
2.
go back to reference Radford EP, Doll R, Smith PG (1977) Mortality among patients with ankylosing spondylitis not given X-ray therapy. N Engl J Med 297:572–576CrossRefPubMed Radford EP, Doll R, Smith PG (1977) Mortality among patients with ankylosing spondylitis not given X-ray therapy. N Engl J Med 297:572–576CrossRefPubMed
3.
go back to reference Kaprove RE, Little AH, Graham DC et al (1980) Ankylosing spondylitis: survival in men with and without radiotherapy. Arthritis Rheum 23:57–61CrossRefPubMed Kaprove RE, Little AH, Graham DC et al (1980) Ankylosing spondylitis: survival in men with and without radiotherapy. Arthritis Rheum 23:57–61CrossRefPubMed
4.
go back to reference Darby SC, Doll R, Gill SK et al (1987) Long term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis. Br J Cancer 55:179–190PubMed Darby SC, Doll R, Gill SK et al (1987) Long term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis. Br J Cancer 55:179–190PubMed
5.
go back to reference Lehtinen K (1993) Mortality and causes of death in 398 patients admitted to hospital with ankylosing spondylitis. Ann Rheum Dis 52:174–176CrossRefPubMed Lehtinen K (1993) Mortality and causes of death in 398 patients admitted to hospital with ankylosing spondylitis. Ann Rheum Dis 52:174–176CrossRefPubMed
6.
go back to reference Salmon JE, Roman MJ (2008) Subclinical atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. Am J Med 121(10 Suppl 1):S3–S8CrossRefPubMed Salmon JE, Roman MJ (2008) Subclinical atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. Am J Med 121(10 Suppl 1):S3–S8CrossRefPubMed
7.
go back to reference Pereira IA, Borba EF (2008) The role of inflammation, humoral and cell mediated autoimmunity in the pathogenesis of atherosclerosis. Swiss Med Wkly 138(37–38):534–539 Pereira IA, Borba EF (2008) The role of inflammation, humoral and cell mediated autoimmunity in the pathogenesis of atherosclerosis. Swiss Med Wkly 138(37–38):534–539
8.
go back to reference Sattar N, McCarey DW, Capell H, McInnes IB (2003) Explaining how ‘‘high-grade’’ systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 108:2957–2963CrossRefPubMed Sattar N, McCarey DW, Capell H, McInnes IB (2003) Explaining how ‘‘high-grade’’ systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 108:2957–2963CrossRefPubMed
10.
go back to reference Wick G, Knoflach M, Xu Q (2004) Autoimmune and inflammatory mechanisms in atherosclerosis. Ann Rev Immunol 22:361–403CrossRef Wick G, Knoflach M, Xu Q (2004) Autoimmune and inflammatory mechanisms in atherosclerosis. Ann Rev Immunol 22:361–403CrossRef
11.
go back to reference Doria A, Sherer Y, Meroni PT, Schoenfeld Y (2005) Inflammation and accelerated atherosclerosis. Basic mechanisms. Rheum Dis N Am 31:355–362CrossRef Doria A, Sherer Y, Meroni PT, Schoenfeld Y (2005) Inflammation and accelerated atherosclerosis. Basic mechanisms. Rheum Dis N Am 31:355–362CrossRef
12.
go back to reference Maksimowicz-McKinnon K, Bhatt DL, Calabrese LH (2004) Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers. Curr Opin Rheumatol 16(1):18–24CrossRefPubMed Maksimowicz-McKinnon K, Bhatt DL, Calabrese LH (2004) Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers. Curr Opin Rheumatol 16(1):18–24CrossRefPubMed
13.
go back to reference Hahn BH, Grossman J, Chen W, McMahon M (2007) The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia. J Autoimmun 28(2–3):69–75CrossRefPubMed Hahn BH, Grossman J, Chen W, McMahon M (2007) The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia. J Autoimmun 28(2–3):69–75CrossRefPubMed
14.
go back to reference Han C, Robinson DW Jr, Hackett MV, Paramore LC, Fraeman KH, Bala MV (2006) Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. J Rheumatol 33(11):2167–2172PubMed Han C, Robinson DW Jr, Hackett MV, Paramore LC, Fraeman KH, Bala MV (2006) Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. J Rheumatol 33(11):2167–2172PubMed
15.
go back to reference Sharrett AR, Ballantyne CM, Coady SA et al (2001) Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: the atherosclerosis risk in communities (ARIC) study. Circulation 104:1108–1113CrossRefPubMed Sharrett AR, Ballantyne CM, Coady SA et al (2001) Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: the atherosclerosis risk in communities (ARIC) study. Circulation 104:1108–1113CrossRefPubMed
16.
go back to reference Rosenson RS (2005) Low high-density lipoprotein cholesterol disorders and cardiovascular risk: contribution of associated low-density lipoprotein subclass abnormalities. Curr Opin Cardiol 20:313–317CrossRefPubMed Rosenson RS (2005) Low high-density lipoprotein cholesterol disorders and cardiovascular risk: contribution of associated low-density lipoprotein subclass abnormalities. Curr Opin Cardiol 20:313–317CrossRefPubMed
17.
go back to reference Rader DJ (2002) High density lipoproteins and atherosclerosis. Am J Cardiol 90(suppl):i62–i70CrossRef Rader DJ (2002) High density lipoproteins and atherosclerosis. Am J Cardiol 90(suppl):i62–i70CrossRef
18.
go back to reference Rossner S (1978) Further studies on serum lipoproteins in connective tissue diseases. Atherosclerosis 31:93–99CrossRefPubMed Rossner S (1978) Further studies on serum lipoproteins in connective tissue diseases. Atherosclerosis 31:93–99CrossRefPubMed
19.
go back to reference Joven J, Rubies-Prat J, Ras MR, de la Figuera M, Lience E, Masdeu S (1984) High density lipoprotein cholesterol subfractions and apolipoprotein A-I in patients with rheumatoid arthritis and ankylosing spondylitis. Arhtritis Rheum 27:1199–2000CrossRef Joven J, Rubies-Prat J, Ras MR, de la Figuera M, Lience E, Masdeu S (1984) High density lipoprotein cholesterol subfractions and apolipoprotein A-I in patients with rheumatoid arthritis and ankylosing spondylitis. Arhtritis Rheum 27:1199–2000CrossRef
20.
go back to reference Divecha H, Sattar N, Rumley A, Cherry L, Lowe GDO, Sturrock R (2005) Cardiovascular risk parameters in men with ankylosing spondylitis in comparison with non-inflammatory control subjects: relevance of systemic inflammation. Clin Sci (Lond) 109(2):171–176CrossRef Divecha H, Sattar N, Rumley A, Cherry L, Lowe GDO, Sturrock R (2005) Cardiovascular risk parameters in men with ankylosing spondylitis in comparison with non-inflammatory control subjects: relevance of systemic inflammation. Clin Sci (Lond) 109(2):171–176CrossRef
21.
go back to reference Malesci D, Niglio A, Mennillo GA, Buono R, Valentini G, La Montagna G (2007) High prevalence of metabolic syndrome in patients with ankylosing spondylitis. Clin Rheumatol 26(5):710–714CrossRefPubMed Malesci D, Niglio A, Mennillo GA, Buono R, Valentini G, La Montagna G (2007) High prevalence of metabolic syndrome in patients with ankylosing spondylitis. Clin Rheumatol 26(5):710–714CrossRefPubMed
22.
go back to reference van Halm VP, van Denderen JC, Peters MJ, Twisk JW, van der Paardt M, van der Horst-Bruinsma IE, van de Stadt RJ, de Koning MH, Dijkmans BA, Nurmohamed MT (2006) Increased disease activity is associated with a deteriorated lipid profile in patients with ankylosing spondylitis. Ann Rheum Dis 65(11):1473–1477CrossRefPubMed van Halm VP, van Denderen JC, Peters MJ, Twisk JW, van der Paardt M, van der Horst-Bruinsma IE, van de Stadt RJ, de Koning MH, Dijkmans BA, Nurmohamed MT (2006) Increased disease activity is associated with a deteriorated lipid profile in patients with ankylosing spondylitis. Ann Rheum Dis 65(11):1473–1477CrossRefPubMed
23.
go back to reference Masi AT, Aldag JC, Mohan PC, Murugan TSR (1999) Determinants of significantly lower serum total cholesterol levels in ankylosing spondylitis patients than age-, gender-, and medical service-matched control patients: results of multivariate analysis. Arthritis Rheum 42(Suppl):S300 Masi AT, Aldag JC, Mohan PC, Murugan TSR (1999) Determinants of significantly lower serum total cholesterol levels in ankylosing spondylitis patients than age-, gender-, and medical service-matched control patients: results of multivariate analysis. Arthritis Rheum 42(Suppl):S300
24.
go back to reference Masi AT, Aldag JC, Mohan PC, Murugan TSR (2000) Significantly lower serum triglyceride levels in ankylosing spondylitis patients than age-, gender-, and medical service-matched controls: results of multivariate analysis. Arthritis Rheum 43(Suppl):S104 Masi AT, Aldag JC, Mohan PC, Murugan TSR (2000) Significantly lower serum triglyceride levels in ankylosing spondylitis patients than age-, gender-, and medical service-matched controls: results of multivariate analysis. Arthritis Rheum 43(Suppl):S104
25.
go back to reference Burger D, Dayer JM (2002) High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation? Autoimmun Rev 1:111–117CrossRefPubMed Burger D, Dayer JM (2002) High-density lipoprotein-associated apolipoprotein A-I: the missing link between infection and chronic inflammation? Autoimmun Rev 1:111–117CrossRefPubMed
26.
go back to reference Hulthe J, Fagerberg B (2002) Circulating oxidized LDL is associated with subclinical atherosclerosis development and inflammatory cytokines (AIR study). Arterioscler Thromb Vasc Biol 22:1162–1167CrossRefPubMed Hulthe J, Fagerberg B (2002) Circulating oxidized LDL is associated with subclinical atherosclerosis development and inflammatory cytokines (AIR study). Arterioscler Thromb Vasc Biol 22:1162–1167CrossRefPubMed
27.
go back to reference Tabas I, Williams KJ, Borén J (2007) Subendothelial lipoprotein retention as the initiating process in atherosclerosis. Update and therapeutic implications. Circulation 116:1832–1844CrossRefPubMed Tabas I, Williams KJ, Borén J (2007) Subendothelial lipoprotein retention as the initiating process in atherosclerosis. Update and therapeutic implications. Circulation 116:1832–1844CrossRefPubMed
28.
go back to reference Marcora S, Casanova F, Williams E et al (2006) Preliminary evidence for cachexia in patients with well established ankylosing spondylitis. Rheumatology (Oxford) 45:1385–1388CrossRef Marcora S, Casanova F, Williams E et al (2006) Preliminary evidence for cachexia in patients with well established ankylosing spondylitis. Rheumatology (Oxford) 45:1385–1388CrossRef
29.
go back to reference Engvall IL, Elkan AC, Tengstrand B, Cederholm T, Brismar K, Hafstrom I (2008) Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin-like growth factor. Scand J Rheumatol 37(5):321–328CrossRefPubMed Engvall IL, Elkan AC, Tengstrand B, Cederholm T, Brismar K, Hafstrom I (2008) Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin-like growth factor. Scand J Rheumatol 37(5):321–328CrossRefPubMed
30.
go back to reference Hennekens CH (2000) Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101:1767–1772PubMed Hennekens CH (2000) Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101:1767–1772PubMed
31.
go back to reference Luc G, Bard JM, Juhan-Vague I et al (2003) C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME study. Arterioscler Thromb Vasc Biol 23:55–1261CrossRef Luc G, Bard JM, Juhan-Vague I et al (2003) C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME study. Arterioscler Thromb Vasc Biol 23:55–1261CrossRef
32.
go back to reference Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V (2000) Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148:209–214CrossRefPubMed Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V (2000) Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148:209–214CrossRefPubMed
33.
34.
go back to reference Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115(10):1285–1295PubMed Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115(10):1285–1295PubMed
35.
go back to reference Ganz P, Vita JA (2003) Testing endothelial vasomotor function. Nitric oxide, a multipotent molecule. Circulation 108:2049–2053CrossRefPubMed Ganz P, Vita JA (2003) Testing endothelial vasomotor function. Nitric oxide, a multipotent molecule. Circulation 108:2049–2053CrossRefPubMed
36.
go back to reference Landmesser U, Hornig B, Drexler H (2004) Endothelial function: a critical determinant in atherosclerosis? Circulation 109(suppl II):II-27–II-33CrossRef Landmesser U, Hornig B, Drexler H (2004) Endothelial function: a critical determinant in atherosclerosis? Circulation 109(suppl II):II-27–II-33CrossRef
37.
go back to reference Widlansky ME, Gokce NL, Keaney JF Jr, Vita JA (2003) The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42:1149–1160CrossRefPubMed Widlansky ME, Gokce NL, Keaney JF Jr, Vita JA (2003) The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42:1149–1160CrossRefPubMed
38.
go back to reference Langheinrich AC, Kampschulte M, Buch T, Bohle RM (2007) Vasa vasorum and atherosclerosis—Quid novi? Thromb Haemost 97(6):873–879PubMed Langheinrich AC, Kampschulte M, Buch T, Bohle RM (2007) Vasa vasorum and atherosclerosis—Quid novi? Thromb Haemost 97(6):873–879PubMed
39.
go back to reference Amoroso A, Del Porto F, Di Monaco C, Manfredini P, Afeltra A (1997) Vascular endothelial growth factor: a key mediator of neoangiogenesis. A review. Eur Rev Med Pharmacol Sci 1:17–25PubMed Amoroso A, Del Porto F, Di Monaco C, Manfredini P, Afeltra A (1997) Vascular endothelial growth factor: a key mediator of neoangiogenesis. A review. Eur Rev Med Pharmacol Sci 1:17–25PubMed
40.
go back to reference Ballara SC, Miotla JM, Paleolog EM (1999) New vessels, new approaches:angiogenesis as a therapeutic target in musculoskeletal disorders. Int J Exp Pathol 80:235–250CrossRefPubMed Ballara SC, Miotla JM, Paleolog EM (1999) New vessels, new approaches:angiogenesis as a therapeutic target in musculoskeletal disorders. Int J Exp Pathol 80:235–250CrossRefPubMed
41.
go back to reference Benjamin M, Toumi H, Suzuki D, Hayashi K, McGonagle D (2008) Evidence for a distinctive pattern of bone formation in enthesophytes. Ann Rheum Dis. 2008 Jul 14. [Epub ahead of print] Benjamin M, Toumi H, Suzuki D, Hayashi K, McGonagle D (2008) Evidence for a distinctive pattern of bone formation in enthesophytes. Ann Rheum Dis. 2008 Jul 14. [Epub ahead of print]
42.
go back to reference Goldberger C, Dulak J, Duftner C, Weidinger F, Falkenbach A, Schirmer M (2002) Vascular endothelial growth factor (VEGF) in ankylosing spondylitis–a pilot study. Wien Med Wochenschr 152(9–10):223–225CrossRefPubMed Goldberger C, Dulak J, Duftner C, Weidinger F, Falkenbach A, Schirmer M (2002) Vascular endothelial growth factor (VEGF) in ankylosing spondylitis–a pilot study. Wien Med Wochenschr 152(9–10):223–225CrossRefPubMed
43.
go back to reference Drouart M, Saas P, Billot M, Cedoz J-P, Tiberghien P, Wendling D, Toussirot É (2003) High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies. Clin Exp Immunol 132:158–162CrossRefPubMed Drouart M, Saas P, Billot M, Cedoz J-P, Tiberghien P, Wendling D, Toussirot É (2003) High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies. Clin Exp Immunol 132:158–162CrossRefPubMed
44.
go back to reference Taylor HG, Weiss JB, McLaughlin B, Dawes PT (1993) Raised endothelial cell stimulating angiogenesis factor in ankylosing spondylitis. Clin Exp Rheumatol 11(5):537–539PubMed Taylor HG, Weiss JB, McLaughlin B, Dawes PT (1993) Raised endothelial cell stimulating angiogenesis factor in ankylosing spondylitis. Clin Exp Rheumatol 11(5):537–539PubMed
45.
go back to reference Jones PB, Makki RJ, Weiss JB (1994) Endothelial cell stimulating angiogenesis factor–a new biological marker for disease activity in ankylosing spondylitis? Br J Rheumatol 33(4):332–335CrossRefPubMed Jones PB, Makki RJ, Weiss JB (1994) Endothelial cell stimulating angiogenesis factor–a new biological marker for disease activity in ankylosing spondylitis? Br J Rheumatol 33(4):332–335CrossRefPubMed
46.
go back to reference Karoli NA, Rebrov AP (2007) Vascular wall lesion and disorder of endothelial vasoregulating function in patients with ankylosing spondylitis. Klin Med (Mosk) 85(6):54–57 Karoli NA, Rebrov AP (2007) Vascular wall lesion and disorder of endothelial vasoregulating function in patients with ankylosing spondylitis. Klin Med (Mosk) 85(6):54–57
47.
go back to reference Poddubnyĭ DA, Rebrov AP (2007) Endothelial dysfunction in patients with Bechterew’s disease (ankylosing spondylitis). Klin Med (Mosk) 85(7):66–69 Poddubnyĭ DA, Rebrov AP (2007) Endothelial dysfunction in patients with Bechterew’s disease (ankylosing spondylitis). Klin Med (Mosk) 85(7):66–69
48.
go back to reference George F, Brisson C, Poncelet P, Laurent JC, Massot O, Arnoux D, Ambrosi P, Klein-Soyer C, Cazenave JP, Sampol J (1992) Rapid isolation of human endothelial cells from whole blood using S-Endo1 monoclonal antibody coupled to immuno-magnetic beads: demonstration of endothelial injury after angioplasty. Thromb Haemost 67:147–153PubMed George F, Brisson C, Poncelet P, Laurent JC, Massot O, Arnoux D, Ambrosi P, Klein-Soyer C, Cazenave JP, Sampol J (1992) Rapid isolation of human endothelial cells from whole blood using S-Endo1 monoclonal antibody coupled to immuno-magnetic beads: demonstration of endothelial injury after angioplasty. Thromb Haemost 67:147–153PubMed
49.
go back to reference Braun J, Sieper J, Breban M, Collantes-Estevez E, Davis J, Inman R et al (2002) Anti-tumournecrosis factor alpha therapy for ankylosing spondylitis: international experience. Ann Rheum Dis 61(Suppl 3):iii51–iii60PubMed Braun J, Sieper J, Breban M, Collantes-Estevez E, Davis J, Inman R et al (2002) Anti-tumournecrosis factor alpha therapy for ankylosing spondylitis: international experience. Ann Rheum Dis 61(Suppl 3):iii51–iii60PubMed
50.
go back to reference Gratacos J, Collado A, Filella X, Sanmarti R, Canete J, Llena J et al (1994) Serum cytokines(IL-6, TNF-alpha, IL-1 beta and IFN-gamma) in ankylosing spondylitis: a closecorrelation between serum IL-6 and disease activity and severity. Br J Rheumatol 33(10):927–931CrossRefPubMed Gratacos J, Collado A, Filella X, Sanmarti R, Canete J, Llena J et al (1994) Serum cytokines(IL-6, TNF-alpha, IL-1 beta and IFN-gamma) in ankylosing spondylitis: a closecorrelation between serum IL-6 and disease activity and severity. Br J Rheumatol 33(10):927–931CrossRefPubMed
51.
go back to reference Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation ofnitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399(6736):601–605CrossRefPubMed Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation ofnitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399(6736):601–605CrossRefPubMed
52.
go back to reference Caliskan M, Erdogan D, Gullu H, Yilmaz S, Gursoy Y, Yildirir A et al (2008) Impaired coronary microvascular and left ventricular diastolic functions in patients with ankylosing spondylitis. Atherosclerosis 196(1):306–312CrossRefPubMed Caliskan M, Erdogan D, Gullu H, Yilmaz S, Gursoy Y, Yildirir A et al (2008) Impaired coronary microvascular and left ventricular diastolic functions in patients with ankylosing spondylitis. Atherosclerosis 196(1):306–312CrossRefPubMed
53.
go back to reference Choe JY, Lee MY, Rheem I, Rhee MY, Park SH, Kim SK (2008) No differences of carotid intima-media thickness between young patients with ankylosing spondylitis and healthy controls. Joint Bone Spine 75(5):548–553CrossRefPubMed Choe JY, Lee MY, Rheem I, Rhee MY, Park SH, Kim SK (2008) No differences of carotid intima-media thickness between young patients with ankylosing spondylitis and healthy controls. Joint Bone Spine 75(5):548–553CrossRefPubMed
54.
go back to reference de Jongh RT, Ijzerman RG, Serne EH, Voordouw JJ, Yudkin JS, de Waal HA et al (2006) Visceral and truncal subcutaneous adipose tissue are associated with impaired capillaryrecruitment in healthy individuals. J Clin Endocrinol Metab 91(12):5100–5106CrossRefPubMed de Jongh RT, Ijzerman RG, Serne EH, Voordouw JJ, Yudkin JS, de Waal HA et al (2006) Visceral and truncal subcutaneous adipose tissue are associated with impaired capillaryrecruitment in healthy individuals. J Clin Endocrinol Metab 91(12):5100–5106CrossRefPubMed
55.
go back to reference Ijzerman RG, Voordouw JJ, van Weissenbruch MM, Yudkin JS, Serne EH, Delemarrevande Waal HA et al (2006) TNF-alpha levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-alpha and insulin resistance. Clin Sci (Lond) 110(3):361–368CrossRef Ijzerman RG, Voordouw JJ, van Weissenbruch MM, Yudkin JS, Serne EH, Delemarrevande Waal HA et al (2006) TNF-alpha levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-alpha and insulin resistance. Clin Sci (Lond) 110(3):361–368CrossRef
56.
go back to reference Wofford J, Kahl F, Howard G, McKinney W, Toole J, Crouse JI (1991) Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arterioscler Thromb 11(6):1786–1794PubMed Wofford J, Kahl F, Howard G, McKinney W, Toole J, Crouse JI (1991) Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arterioscler Thromb 11(6):1786–1794PubMed
57.
go back to reference Sari I, Okan T, Akar S, Cece H, Altay C, Secil M, Birlik M, Onen F, Akkoc N (2006) Impaired endothelial function in patients with ankylosing spondylitis. Rheumatology 45:283–286CrossRefPubMed Sari I, Okan T, Akar S, Cece H, Altay C, Secil M, Birlik M, Onen F, Akkoc N (2006) Impaired endothelial function in patients with ankylosing spondylitis. Rheumatology 45:283–286CrossRefPubMed
58.
go back to reference Mathieu S, Joly H, Baron G, Tournadre A, Dubost J-J, Ristori J-M, Lusson J-R, Soubrier M (2008) Trend towards increased arterial stiffness or intima–media thickness in ankylosing spondylitis patients without clinically evident cardiovascular disease. Rheumatology 47:1203–1207CrossRefPubMed Mathieu S, Joly H, Baron G, Tournadre A, Dubost J-J, Ristori J-M, Lusson J-R, Soubrier M (2008) Trend towards increased arterial stiffness or intima–media thickness in ankylosing spondylitis patients without clinically evident cardiovascular disease. Rheumatology 47:1203–1207CrossRefPubMed
59.
go back to reference Pieringer H (2006) Impaired endothelial function in patients with ankylosing spondylitis. Rheumatology (Oxford) 45(10):1319; author reply 1319–20. Comment on:Rheumatology (Oxford). 2006 Mar;45(3):283–286 Pieringer H (2006) Impaired endothelial function in patients with ankylosing spondylitis. Rheumatology (Oxford) 45(10):1319; author reply 1319–20. Comment on:Rheumatology (Oxford). 2006 Mar;45(3):283–286
60.
go back to reference Galderisi M, Cicala S, Caso P et al (2002) Coronary flow reserve andmyocardial diastolic dysfunction in arterial hypertension. AmJ Cardiol 90:860–864CrossRef Galderisi M, Cicala S, Caso P et al (2002) Coronary flow reserve andmyocardial diastolic dysfunction in arterial hypertension. AmJ Cardiol 90:860–864CrossRef
61.
go back to reference Erdogan D, Gullu H, Caliskan M et al (2005) Coronary flow reserve in dipper and non-dipper hypertensive patients. Blood Press 14:345–352CrossRefPubMed Erdogan D, Gullu H, Caliskan M et al (2005) Coronary flow reserve in dipper and non-dipper hypertensive patients. Blood Press 14:345–352CrossRefPubMed
62.
go back to reference van Eijk IC, Peters MJL, Serne EH, van der Horst-Bruinsma IE, Dijkmans BAC, Smulders YM, Nurmohamed MT (2008) Microvascular function is impaired in ankylosing spondylitis and improves after TNF blockade. Ann Rheum Dis 2008 Apr 4. [Epub ahead of print] van Eijk IC, Peters MJL, Serne EH, van der Horst-Bruinsma IE, Dijkmans BAC, Smulders YM, Nurmohamed MT (2008) Microvascular function is impaired in ankylosing spondylitis and improves after TNF blockade. Ann Rheum Dis 2008 Apr 4. [Epub ahead of print]
63.
go back to reference Braun J, Davis J, Dougados M, Sieper J, van der LS, van der HD (2006) First update of the international ASAS consensus statement for the use of anti-TNF agents in patients with ankylosing spondylitis. Ann Rheum Dis 65(3):316–320CrossRefPubMed Braun J, Davis J, Dougados M, Sieper J, van der LS, van der HD (2006) First update of the international ASAS consensus statement for the use of anti-TNF agents in patients with ankylosing spondylitis. Ann Rheum Dis 65(3):316–320CrossRefPubMed
64.
go back to reference Rudwaleit M, Listing J, Marker-Hermann E et al (2004) Spinal mobility in early ankylosing spondylitis and in axial SpA without definite radiographic sacroillitis. Ann Rheum Dis 63(Suppl 1):400 Rudwaleit M, Listing J, Marker-Hermann E et al (2004) Spinal mobility in early ankylosing spondylitis and in axial SpA without definite radiographic sacroillitis. Ann Rheum Dis 63(Suppl 1):400
Metadata
Title
Atherosclerosis and endothelial dysfunction in patients with ankylosing spondylitis
Authors
V. F. Azevedo
R. Pecoits-Filho
Publication date
01-09-2010
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 11/2010
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-010-1416-3

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine