Top

Published in:

01-04-2010 | Short Communication

Elevation of serum IgG subclass concentration in patients with rheumatoid arthritis

Authors: Guigao Lin, Jinming Li

Published in: Rheumatology International | Issue 6/2010

Abstract

A new concept of IgG subclass such as IgG4-related systemic disease including autoimmune pancreatitis, characterized by a high-serum IgG4 level, has been proposed. Our aim was to investigate serum IgG subclass levels in rheumatoid arthritis (RA). IgG subclass levels of sera from 72 patients with rheumatoid arthritis were determined by immunonephelometric assay. The patients were divided into two groups according to clinical activity of the disease: active disease and remission. The sera from 45 normal controls were also measured. All statistical analyses were carried out with SPSS software version 13.0. We found a significant increase of all the four IgG subclass concentrations in sera of patients with RA compared to those of the controls (P < 0.001). When the patients were divided according to clinical activity, the IgG subclass concentrations were similar between the two groups (P > 0.05). Our data suggest that besides IgG1, IgG2 and IgG3, IgG4 may involve in the pathogenesis of the disease.

Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa K (2001) High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 344:732–738CrossRefPubMed

Chapuy-Regaud S, Nogueira L, Clavel C, Sebbag M, Vincent C, Serre G (2005) IgG subclass distribution of the rheumatoid arthritis-specific autoantibodies to citrullinated fibrin. Clin Exp Immunol 139:542–550CrossRefPubMed

Martini A, Plebani A, Ravelli A, Avanzini MA, Jefferis R, Zonta L, Notarangelo LD, Ugazio AG, Burgio R (1986) IgG subclass serum levels in juvenile chronic arthritis. Ann Rheum Dis 45:400–404CrossRefPubMed

Shakib F, Stanworth DR (1976) IgG subclass composition of rheumatoid arthritic sera and joint fluids. Ann Rheum Dis 35:263–266CrossRefPubMed

Pressac M, Allouche F, Circaud R, Aymard P (1995) Evaluation of human IgG subclass assays on Beckman array. Ann Clin Biochem 32(Pt 3):281–288PubMed

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324CrossRefPubMed

Fransen J, Langenegger T, Michel BA, Stucki G (2000) Feasibility and validity of the RADAI, a self-administered rheumatoid arthritis disease activity index. Rheumatology (Oxford) 39:321–327CrossRef

Martini A, Avanzini MA, Ravelli A, Zonta L, Plebani A, de Benedetti F, Burgio RG (1989) Variation of serum IgG subclass concentrations with disease activity in juvenile chronic arthritis. Ann Rheum Dis 48:582–585CrossRefPubMed

Ravetch JV, Bolland S (2001) IgG Fc receptors. Annu Rev Immunol 19:275–290CrossRefPubMed

10.

Engelmann R, Brandt J, Eggert M, Karberg K, Krause A, Neeck G, Mueller-Hilke B (2008) IgG1 and IgG4 are the predominant subclasses among auto-antibodies against two citrullinated antigens in RA. Rheumatology (Oxford) 47:1489–1492CrossRef

11.

Cohen PL, Cheek RL, Hadler JA, Yount WJ, Eisenberg RA (1987) The subclass distribution of human IgG rheumatoid factor. J Immunol 139:1466–1471PubMed

12.

Mihai S, Chiriac MT, Herrero-Gonzalez JE, Goodall M, Jefferis R, Savage CO, Zillikens D, Sitaru C (2007) IgG4 autoantibodies induce dermal-epidermal separation. J Cell Mol Med 11:1117–1128CrossRefPubMed

13.

Kawa S, Kitahara K, Hamano H, Ozaki Y, Arakura N, Yoshizawa K, Umemura T, Ota M, Mizoguchi S, Shimozuru Y, Bahram S (2008) A novel immunoglobulin - immunoglobulin interaction in autoimmunity. PLoS ONE 3:e1637CrossRefPubMed

14.

van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martínez-Martínez P, Vermeulen E, den Bleker TH, Wiegman L, Vink T, Aarden LA, De Baets MH, van de Winkel JG, Aalberse RC, Parren PW (2007) Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 317:1554–1557CrossRefPubMed

15.

Aalberse RC, van der Gaag R, van Leeuwen J (1983) Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol 130:722–726PubMed

Title: Elevation of serum IgG subclass concentration in patients with rheumatoid arthritis
Authors: Guigao Lin
Jinming Li
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 6/2010
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-1330-8

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 6/2010

Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1

Increased plasma myeloperoxidase levels in systemic lupus erythematosus

Abatacept as an option therapy in difficult to treat psoriatic arthritis

Rapidly progressive neuropathic arthropathy of the knee in possible association with a huge extruded cervical intervertebral disc herniation

Long-term remission of severe refractory dermatopolymyositis with a weekly-scheme of immunoglobulin followed by rituximab therapy

Spontaneous displacement of olecranon fracture through geode salvaged by elbow replacement

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials