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Rheumatology International
Published in: Rheumatology International 4/2007

01-02-2007 | Case Report

Hypertrophic pulmonary osteoarthropathy (HPOA) (Pierre Marie–Bamberger syndrome): two cases presenting as acute inflammatory arthritis. Description and review of the literature

Authors: David J. Armstrong, Elisabeth M. A. McCausland, Gary D. Wright

Published in: Rheumatology International | Issue 4/2007

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Abstract

We report the cases of two middle-aged male smokers who presented to the early synovitis clinic with an acute phase response, synovitis of the wrists and ankles and clubbing of the fingers, but no respiratory symptoms. Both proved to have primary lung tumours with hypertrophic pulmonary osteoarthropathy, in one case resolving promptly with treatment of the carcinoma. We review the literature, including theories on pathogenesis.
Literature
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Martinez-Lavin M, Pineda C, Valdez T et al (1988) Primary hypertrophic osteoarthropathy. Semin Arthritis Rheum 17:156–162PubMedCrossRef
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Yacoub MH (1965) Cervical vagotomy for pulmonary osteoarthropathy. Br J Chest 59:28–31CrossRef
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Stenseth JH, Clagett OT, Woolner LB (1967) Hypertrophic pulmonary osteoarthropathy. Dis Chest 52:62–68PubMed
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Segal AM, MacKenzie AH (1982) Hypertrophic osteoarthropathy: a 10 year retrospective analysis. Semin Arthritis Rheum 12:220–232PubMedCrossRef
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Nishi K, Matsumura M, Myou S et al (1994) Two cases of pulmonary hypertrophic osteoarthropathy associated with primary lung cancer, in which symptoms were rapidly improved by resection of the primary lesions. Nihon Kyobu Shikkan Gakkai Zasshi 32:271–276PubMed
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Schumacher R (1976) Articular manifestations of hypertrophic pulmonary osteoarthropathy in bronchogenic carcinoma. Arthritis Rheum 19:629–635PubMedCrossRef
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Gosney MA, Gosney JR, Lye M (1990) Plasma growth hormone and digital clubbing in carcinoma of the bronchus. Thorax 45:545–547PubMedCrossRef
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Hojo S, Fujita J, Yamadori I et al (1997) Hepatocyte growth factor and digital clubbing. Intern Med 36:44–46PubMed
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Uchisanko H, Suga K, Tanaka N et al (1995) Bone scintigraphy in growth-hormone-secreting pulmonary cancer and hypertrophic pulmonary osteoarthropathy. J Nucl Med 99:662–671
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Dickinson CJ, Martin JF (1987) Megakaryocytes and platelet clumps as the cause of finger clubbing. Lancet 14:6–8
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Marinez-Levin M, Pineda C (2003) Hypertrophic osteoarthropathy. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (eds) Rheumatology, 3rd edn. Mosby, Edinburgh, pp 1763–1767
Metadata
Title
Hypertrophic pulmonary osteoarthropathy (HPOA) (Pierre Marie–Bamberger syndrome): two cases presenting as acute inflammatory arthritis. Description and review of the literature
Authors
David J. Armstrong
Elisabeth M. A. McCausland
Gary D. Wright
Publication date
01-02-2007
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 4/2007
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-006-0224-2

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