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Published in:

01-05-2018 | Review

Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation

Authors: Linda S. Sorkin, Kelly A. Eddinger, Sarah A. Woller, Tony L. Yaksh

Published in: Seminars in Immunopathology | Issue 3/2018

Abstract

Neurogenic inflammation results from the release of biologically active agents from the peripheral primary afferent terminal. This release reflects the presence of releasable pools of active product and depolarization-exocytotic coupling mechanisms in the distal afferent terminal and serves to alter the physiologic function of innervated organ systems ranging from the skin and meninges to muscle, bone, and viscera. Aside from direct stimulation, this biologically important release from the peripheral afferent terminal can be initiated by antidromic activity arising from five anatomically distinct points of origin: (i) afferent collaterals at the peripheral-target organ level, (ii) afferent collaterals arising proximal to the target organ, (iii) from mid-axon where afferents lacking myelin sheaths (C fibers and others following demyelinating injuries) may display crosstalk and respond to local irritation, (iv) the dorsal root ganglion itself, and (v) the central terminals of the afferent in the dorsal horn where local circuits and bulbospinal projections can initiate the so-called dorsal root reflexes, i.e., antidromic traffic in the sensory afferent.

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Title: Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation
Authors: Linda S. Sorkin
Kelly A. Eddinger
Sarah A. Woller
Tony L. Yaksh
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: Seminars in Immunopathology / Issue 3/2018
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-017-0669-2

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