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Seminars in Immunopathology
Published in: Seminars in Immunopathology 3/2012

01-05-2012 | Review

Sialoadhesin in recognition of self and non-self

Authors: Mariliis Klaas, Paul R. Crocker

Published in: Seminars in Immunopathology | Issue 3/2012

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Abstract

The immune system is tightly regulated to maintain an appropriate balance between immune activation and tolerance. Macrophages play a key role in this process since they express many pathogen recognition molecules as well as receptors for ‘self’. Sialoadhesin is a major macrophage receptor that specifically recognizes sialic acid, an abundant component of host glycoconjugates but which can also be found on several human pathogens. In recent years, several studies have demonstrated that sialoadhesin can contribute to the uptake and processing of sialylated pathogens as well as playing an important role in regulating inflammatory and autoimmune responses via recognition of self.
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Metadata
Title
Sialoadhesin in recognition of self and non-self
Authors
Mariliis Klaas
Paul R. Crocker
Publication date
01-05-2012
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 3/2012
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-012-0310-3

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