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Published in:

01-07-2008 | Review

NOX enzymes and Toll-like receptor signaling

Authors: Eric Ogier-Denis, Sanae Ben Mkaddem, Alain Vandewalle

Published in: Seminars in Immunopathology | Issue 3/2008

Abstract

Invading microorganisms are recognized by the host innate immune system through pattern recognition receptors. Among these receptors, Toll-like receptors (TLRs) are able to sense the molecular signatures of microbial pathogens, protozoa, fungi, and virus and activate proinflammatory signaling cascades. In addition to their role in bacterial killing by phagocytes, reactive oxygen species generated by NADPH oxidase (NOX) homologues also play key roles in signaling and host defense in a variety of cell types. Recent studies have demonstrated a link between TLR activation and NOX homologues following microbial recognition highlighting their important role in the innate immune response and host defense.

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Title: NOX enzymes and Toll-like receptor signaling
Authors: Eric Ogier-Denis
Sanae Ben Mkaddem
Alain Vandewalle
Publication date: 01-07-2008
Publisher: Springer-Verlag
Published in: Seminars in Immunopathology / Issue 3/2008
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-008-0120-9

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Other articles of this Issue 3/2008

NOX enzymes in immuno-inflammatory pathologies

Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane

Genetics and immunopathology of chronic granulomatous disease

Reply to the remarks by Joachim Roesler on the article Genetics and immunopathology of chronic granulomatous disease

The NADPH oxidase NOX2 plays a role in periodontal pathologies

Role of Nox2 in elimination of microorganisms

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