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01-08-2011 | Original Article

Phase I study of LY2181308, an antisense oligonucleotide against survivin, in patients with advanced solid tumors

Authors: M. Tanioka, H. Nokihara, N. Yamamoto, Y. Yamada, K. Yamada, Y. Goto, T. Fujimoto, R. Sekiguchi, K. Uenaka, S. Callies, T. Tamura

Published in: Cancer Chemotherapy and Pharmacology | Issue 2/2011

Abstract

Purpose

LY2181308 is an antisense oligonucleotide that complementarily binds to survivin mRNA and inhibits its expression in tumor tissue. This phase I dose escalation study evaluated the tolerability, pharmacokinetics, and anticancer activity of LY2181308 in Japanese.

Methods

Patients with solid tumors refractory to standard therapy received LY2181308 (400, 600, or 750 mg) as a 3-h intravenous infusion for 3 consecutive days and thereafter once a week.

Results

LY2181308 was administered to 14 patients, aged 44–73 (median 60) years. Flu-like syndrome, prolonged prothrombin time-international normalized ratio (PT-INR), thrombocytopenia, and fatigue were common reversible grade 1/2 toxicities. The dose-limiting toxicity was reversible grade 3 elevation of ALT/AST/γ-GTP in 1 patient treated at the 750-mg dose. Pharmacokinetic analysis showed a long terminal half-life of 21 days and an extensive tissue distribution of LY2181308. In 12 evaluable patients, one patient had stable disease, while the remaining 11 patients had progressive disease.

Conclusions

LY2181308 monotherapy is well tolerated up to 750 mg with a manageable toxicity, the pharmacokinetic profile warrants further evaluation of LY2181308 in combination with cytotoxic agents or radiotherapy.

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Nokihara H, Yamamoto N, Yamada Y, Yamada K, Goto Y, Tanioka M, Nambu Y, Uenaka K, Sekiguchi R, Tamura T (2009) A phase 1 study of an antisense oligonucleotide against survivin (LY2181308) in Japanese patients with solid tumors. Mol Cancer Ther 8:B48. doi:10.1158/1535-7163.TARG-09-B48

Title: Phase I study of LY2181308, an antisense oligonucleotide against survivin, in patients with advanced solid tumors
Authors: M. Tanioka
H. Nokihara
N. Yamamoto
Y. Yamada
K. Yamada
Y. Goto
T. Fujimoto
R. Sekiguchi
K. Uenaka
S. Callies
T. Tamura
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: Cancer Chemotherapy and Pharmacology / Issue 2/2011
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-010-1506-7

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