Published in:
01-05-2010 | Original Article
Meta-analysis of incidence and risk of hypokalemia with cetuximab-based therapy for advanced cancer
Authors:
Yunfei Cao, Lidan Liu, Cun Liao, Aihua Tan, Feng Gao
Published in:
Cancer Chemotherapy and Pharmacology
|
Issue 1/2010
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Abstract
Purpose
To gain a better understanding of the incidence and risk of hypokalemia in patients who received cetuximab-based therapy.
Patients and methods
Databases, including Pubmed, EMBASE, The Cochrane Library, annual meeting of American Society of Clinical Oncology (2000–2008), and Web of science were searched to identify relevant studies. Eligible studies were prospective phase II–III clinical trials of patients with cancer assigned cetuximab at the dose of 400 mg/m2 IV on day 1 and 250 mg/m2 weekly thereafter. The primary endpoint was incidence of hypokalemia.
Results
Eleven clinical reports were identified which included a total of 2,254 patients who were available for analysis, with 1,324 patients assigned cetuximab-based treatment. The results showed high incidence of grade 3 and 4 hypokalemia [6.2% (95% CI 4.9–7.7)] and high incidence of all-grade hypokalemia [8.0% (95% CI 4.5–13.9)] associated with cetuximab-based therapy for advanced cancer. Compared with non-cetuximab therapy, cetuximab-based therapy has higher risk of grade 3 and 4 hypokalemia [1.81 (95% CI 1.12–2.93)].
Conclusion
Cetuximab-based therapy is associated with a significant risk of hypokalemia. Early monitoring and effective management of hypokalemia is important for patients that received cetuximab-based therapy.