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Annals of Hematology
Published in: Annals of Hematology 3/2014

01-03-2014 | Letter to the Editor

ABCB6 RNA expression in leukemias—expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia

Authors: Ajay Abraham, Sreeja Karathedath, Savitha Varatharajan, Preetha Markose, Ezhilarasi Chendamarai, Ashok Kumar Jayavelu, Biju George, Alok Srivastava, Vikram Mathews, Poonkuzhali Balasubramanian

Published in: Annals of Hematology | Issue 3/2014

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Excerpt

Dear Editor, …
Literature
1.
Chavan H, Oruganti M, Krishnamurthy P (2011) The ATP-binding cassette transporter ABCB6 is induced by arsenic and protects against arsenic cytotoxicity. Toxicol Sci 120(2):519–528CrossRefPubMed
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Davison K, Cote S, Mader S, Miller WH (2003) Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines. Leukemia 17(5):931–940CrossRefPubMed
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Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cave H, Pane F, Aerts JL, De Micheli D, Thirion X, Pradel V, Gonzalez M, Viehmann S, Malec M, Saglio G, van Dongen JJ (2003) Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia—a Europe Against Cancer program. Leukemia 17(12):2318–2357CrossRefPubMed
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Gillet JP, Calcagno AM, Varma S, Marino M, Green LJ, Vora MI, Patel C, Orina JN, Eliseeva TA, Singal V, Padmanabhan R, Davidson B, Ganapathi R, Sood AK, Rueda BR, Ambudkar SV, Gottesman MM (2011) Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc Natl Acad Sci U S A 108(46):18708–18713CrossRefPubMedCentralPubMed
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Gupta M, Ashok Kumar J, Sitaram U, Neeraj S, Nancy A, Balasubramanian P, Abraham A, Mathews V, Viswabandya A, George B, Chandy M, Srivastava A, Srivastava VM (2010) The t(6;9)(p22;q34) in myeloid neoplasms: a retrospective study of 16 cases. Cancer Genet Cytogenet 203(2):297–302CrossRefPubMed
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Krishnamurthy P, Schuetz JD (2011) The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival. Curr Pharm Biotechnol 12(4):647–655CrossRefPubMed
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Langmann T, Mauerer R, Zahn A, Moehle C, Probst M, Stremmel W, Schmitz G (2003) Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues. Clin Chem 49(2):230–238CrossRefPubMed
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Marzac C, Garrido E, Tang R, Fava F, Hirsch P, De Benedictis C, Corre E, Lapusan S, Lallemand JY, Marie JP, Jacquet E, Legrand O (2011) ATP Binding Cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their prognostic impact in a cohort of 281 acute myeloid leukemia patients. Haematologica 96(9):1293–1301CrossRefPubMed
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Paterson JK, Shukla S, Black CM, Tachiwada T, Garfield S, Wincovitch S, Ernst DN, Agadir A, Li X, Ambudkar SV, Szakacs G, Akiyama S, Gottesman MM (2007) Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane. Biochemistry 46(33):9443–9452CrossRefPubMed
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Polireddy K, Chavan H, Abdulkarim BA, Krishnamurthy P (2011) Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma. Mol Oncol 5(5):410–425CrossRefPubMedCentralPubMed
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Radich JP (2008) Molecular classification of acute myeloid leukemia: are we there yet? J Clin Oncol 26(28):4539–4541CrossRefPubMed
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Sallmyr A, Fan J, Datta K, Kim KT, Grosu D, Shapiro P, Small D, Rassool F (2008) Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML. Blood 111(6):3173–3182CrossRefPubMed
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Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagari D, Du G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz J (2012) The ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity. J Biol Chem 287(16):12679–12690CrossRefPubMed
Metadata
Title
ABCB6 RNA expression in leukemias—expression is low in acute promyelocytic leukemia and FLT3-ITD-positive acute myeloid leukemia
Authors
Ajay Abraham
Sreeja Karathedath
Savitha Varatharajan
Preetha Markose
Ezhilarasi Chendamarai
Ashok Kumar Jayavelu
Biju George
Alok Srivastava
Vikram Mathews
Poonkuzhali Balasubramanian
Publication date
01-03-2014
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 3/2014
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-013-1821-2

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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