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Published in: Annals of Hematology 12/2010

01-12-2010 | Original Article

Endocrine and bone disease in appropriately treated adult patients with beta-thalassemia major

Authors: Marina Baldini, Stella Forti, Alessia Marcon, Fabio Massimo Ulivieri, Alessandra Orsatti, Benedetta Tampieri, Lorena Airaghi, Laura Zanaboni, Maria Domenica Cappellini

Published in: Annals of Hematology | Issue 12/2010

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Abstract

With the optimization of transfusional and chelation regimens, beta-thalassemia has changed from a pediatric disease with poor life expectancy into a chronic disease. Bone demineralization is an important cause of morbidity in older patients; the etiology is multifactorial and partially unknown. We examined, cross-sectionally, 111 adult patients with beta-thalassemia major (66 females and 45 males, 32.6 ± 6 years) who were regularly transfused, sufficiently chelated and replaced for endocrine defects. Bone demineralization was detected in 92.7% of patients with different severity according to gender and site: osteopenia was the prominent finding at the femur, osteoporosis at the lumbar spine (p < 0.001), more evident in males. The femoral site was more influenced by biochemical and clinical factors; despite adequate replacement, the femoral T-score was lower in the hypogonadic group than in the eugonadic group (p = 0.047). A significant correlation was found between the bone mass and body mass index (BMI), alkaline phosphatase (ALP), and pre-transfusional Hb levels. The multivariate analysis indicated as significant regressors ALP, BMI and hypoparathyroidism (T-score, p = 0.005, 0.035, and 0.002; Z-score, 0.002, 0.009, and 0.003, respectively) at the femoral site; whereas, only ALP at the lumbar spine (p = 0.008 and 0.045 for T-and Z-scores, respectively). The statistical significance was reached more frequently by the T-score, while the Z-score seemed to be a less sensitive parameter. Despite best care facilities, bone demineralization in thalassemic patients remains a challenge. Further exploration of the relationships between bone loss and endocrine, biochemical and hematologic parameters is warranted to find effective measures to reduce the risk of fracture in this disease.
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Metadata
Title
Endocrine and bone disease in appropriately treated adult patients with beta-thalassemia major
Authors
Marina Baldini
Stella Forti
Alessia Marcon
Fabio Massimo Ulivieri
Alessandra Orsatti
Benedetta Tampieri
Lorena Airaghi
Laura Zanaboni
Maria Domenica Cappellini
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
Annals of Hematology / Issue 12/2010
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-010-1007-0

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