Top

Published in:

01-10-2009 | Letter to the Editor

Telomere length of donors influences granulocyte recovery in children after hematopoietic stem cell transplantation

Authors: Rosa Mangerini, Edoardo Lanino, Paola Terranova, Maura Faraci, Maria Pia Pistillo, Gian Franco Gaetani, Anna Maria Ferraris

Published in: Annals of Hematology | Issue 10/2009

Excerpt

Dear Editor, …

Zakian VA (1995) Telomeres: beginning to understand the end. Science 270:1601–1607, doi:10.1126/science.270.5242.1601 PubMedCrossRef

Engelhardt M, Kumar R, Albanell J, Pettengell R, Han W, Moore MA (1997) Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 90:182–193PubMed

Akiyama M, Hoshi Y, Sakurai S, Yamada H, Yamada O, Mizoguchi H (1998) Changes of telomere length in children after hematopoietic stem cell transplantation. Bone Marrow Transplant 21:167–171, doi:10.1038/sj.bmt.1701060 PubMedCrossRef

Shay JW (1998) Accelerated telomere shortening in bone-marrow recipients. Lancet 351:153–154, doi:10.1016/S0140-6736(05)78218-0 PubMedCrossRef

Awaya N, Baerlocher GM, Manley TJ, Sanders JE, Mielcarek M, Torok-Storb B, Lansdorp PM (2002) Telomere shortening in hematopoietic stem cell transplantation: a potential mechanism for late graft failure. Biol Blood Marrow Transplant 8:597–600, doi:10.1053/bbmt.2002.v8.abbmt080597 PubMedCrossRef

Vaziri H, Benchimol S (1998) Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 8:279–282, doi:10.1016/S0960-9822(98)70109-5 PubMedCrossRef

Widmann TA, Willmann B, Pfreundschuh M, Beelen DW (2005) Influence of telomere length on short-term recovery after allogeneic stem cell transplantation. Exp Hematol 33:1257–1261, doi:10.1016/j.exphem.2005.05.019 PubMedCrossRef

Lincz LF, Scorgie FE, Sakoff JA, Fagan KA, Ackland SP, Enno A (2004) Telomere length predicts neutrophil recovery in the absence of G-CSF after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 34:439–445, doi:10.1038/sj.bmt.1704607 PubMedCrossRef

Vaziri H, Schächter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D, Harley CB (1993) Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52:661–667PubMed

10.

Ferraris AM, Pujic N, Mangerini R, Rapezzi D, Gallamini A, Racchi O, Casciaro S, Gaetani GF (2005) Clonal granulocytes in polycythaemia vera and essential thrombocythaemia have shortened telomeres. Br J Haematol 130:391–393, doi:10.1111/j.1365-2141.2005.05618.x PubMedCrossRef

11.

Rufer N, Brümmendorf TH, Chapuis B, Helg C, Lansdorp PM, Roosnek E (2001) Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation. Blood 97:575–577, doi:10.1182/blood.V97.2.575 PubMedCrossRef

12.

Roelofs H, de Pauw ES, Zwinderman AH, Opdam SM, Willemze R, Tanke HJ, Fibbe WE (2003) Homeostasis of telomere length rather than telomere shortening after allogeneic peripheral blood stem cell transplantation. Blood 101:358–362, doi:10.1182/blood-2002-06-1832 PubMedCrossRef

13.

Wynn RF, Cross MA, Hatton C, Will AM, Lashford LS, Dexter TM, Testa NG (1998) Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants. Lancet 351:178–181, doi:10.1016/S0140-6736(97)08256-1 PubMedCrossRef

14.

Lee J, Kook H, Chung I, Kim H, Park M, Kim C, Nah J, Hwang T (1999) Telomere length changes in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 24:411–415, doi:10.1038/sj.bmt.1701923 PubMedCrossRef

15.

Notaro R, Cimmino A, Tabarini D, Rotoli B, Luzzatto L (1997) In vivo telomere dynamics of human hematopoietic stem cells. Proc Natl Acad Sci USA 94:13782–13785, doi:10.1073/pnas.94.25.13782 PubMedCrossRef

Title: Telomere length of donors influences granulocyte recovery in children after hematopoietic stem cell transplantation
Authors: Rosa Mangerini
Edoardo Lanino
Paola Terranova
Maura Faraci
Maria Pia Pistillo
Gian Franco Gaetani
Anna Maria Ferraris
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: Annals of Hematology / Issue 10/2009
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-009-0712-z

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 10/2009

Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms

High CD4/CD8 ratio in allografts predicts adverse outcomes in unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation for chronic myeloid leukemia

Incidental diagnosis of CML in a patient with anemia and IgG lamda monoclonal protein in blood

Hepatitis C antiviral response in thalassemia: what is the role of liver iron concentration?

Newly diagnosed versus relapsed idiopathic thrombotic thrombocytopenic purpura: a comparison of presenting clinical characteristics and response to treatment

The α1-adrenergic receptor antagonists, benoxathian and prazosin, induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials