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Annals of Hematology
Published in: Annals of Hematology 4/2008

01-04-2008 | Original Article

Achievement of optimal average relative dose intensity and correlation with survival in diffuse large B-cell lymphoma patients treated with CHOP

Authors: A. Bosly, D. Bron, A. Van Hoof, R. De Bock, Z. Berneman, A. Ferrant, L. Kaufman, M. Dauwe, G. Verhoef, for the Lymphoma Dose Project: a National Study

Published in: Annals of Hematology | Issue 4/2008

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Abstract

The treatment of diffuse large B-cell lymphoma with chemotherapy was retrospectively evaluated in 348 patients who had received at least three cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)-like, ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone)-like or CHVmP-BV (cyclophosphamide, hydroxorubicin, Vm-26, prednisone, vincristine and bleomycin) treatment in Belgium between 1995 and 2000. In our sample, the proportion who received each of the three regimens was 78.4, 16.4, and 5.2%, respectively. Of those prescribed CHOP-like regimens, 15% received <80% average relative dose intensity (ARDI). In 210 patients treated with CHOP-21 (77% of the CHOP-like group), median survival was 7.08 years in those who received >90% of the ARDI, significantly longer than in those who received ≤;90% of the ARDI (p = 0.002). Dose reductions and/or delays, mainly due to hematological toxicities, resulted in a reduction in treatment intensity. These data indicate that patient outcome is improved when the intensity of chemotherapy treatment is optimal.
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Metadata
Title
Achievement of optimal average relative dose intensity and correlation with survival in diffuse large B-cell lymphoma patients treated with CHOP
Authors
A. Bosly
D. Bron
A. Van Hoof
R. De Bock
Z. Berneman
A. Ferrant
L. Kaufman
M. Dauwe
G. Verhoef
for the Lymphoma Dose Project: a National Study
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
Annals of Hematology / Issue 4/2008
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-007-0399-y

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