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Published in:

01-10-2003

Diagnosis of invasive fungal infections in hematology and oncology

Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

Authors: M. Ruhnke, A. Böhme, D. Buchheidt, K. Donhuijsen, H. Einsele, R. Enzensberger, A. Glasmacher, H. Gümbel, C.-P. Heussel, M. Karthaus, E. Lambrecht, T. Südhoff, H. Szelényi

Published in: Annals of Hematology | Special Issue 2/2003

Abstract

Invasive fungal infections are a primary cause of morbidity and mortality in patients with hematological malignancies. Establishing a definite diagnosis of invasive fungal infection in febrile neutropenic patients is particularly challenging and time-consuming, but a delay of antifungal treatment leads to higher mortality. This situation has lead to the strategy of initiation "empirical" antifungal therapy prior to the detection of fungi. Meanwhile, improvements in diagnostic procedures are achieved, especially with imaging techniques and non-culture based methods which include antigen-based assays, metabolite detection and molecular detection of fungal DNA from body fluid samples using conserved or specific genome sequences. The AGIHO presents recommendations for the diagnosis of invasive fungal infections with risk-adapted screening concepts for the neutropenic and febrile episodes of patients with hemato-oncological disorders.

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Title: Diagnosis of invasive fungal infections in hematology and oncology
Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
Authors: M. Ruhnke
A. Böhme
D. Buchheidt
K. Donhuijsen
H. Einsele
R. Enzensberger
A. Glasmacher
H. Gümbel
C.-P. Heussel
M. Karthaus
E. Lambrecht
T. Südhoff
H. Szelényi
Publication date: 01-10-2003
Publisher: Springer-Verlag
Published in: Annals of Hematology / Issue Special Issue 2/2003
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-003-0768-0

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