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Surgical and Radiologic Anatomy

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01-07-2013 | Anatomic Bases of Medical, Radiological and Surgical Techniques

Demonstration of different histological layers of the pachygyria/agyria cortex using diffusion tensor MR imaging

Authors: Zarina A. Aziz, Jitender Saini, P. S. Bindu, G. G. Sharath Kumar

Published in: Surgical and Radiologic Anatomy | Issue 5/2013

Abstract

Purpose

Pachygyria/agyria are congenital brain malformations characterized by presence of a few broad, flat gyri with thickened cortex, resulting from arrest of neuronal migration in early gestation. We are hereby describing diffusion tensor imaging findings in different histological layers of lissencephaly cortex in two children.

Method

DTI in addition to conventional MR imaging was performed in two children on a 3 T MRI and post-processed with vendor supplied software to generate the fractional anisotropy, mean diffusivity and trace maps. Tractography was also performed to identify presence of tracts in the thickened cortex.

Results

DTI demonstrated the dysplastic multilayered cortex in cases of pachygyria/agyria; the thickened fourth layer and superficial layer demonstrated high anisotropy on diffusion tensor imaging.

Conclusion

DTI is a useful tool for identifying gross histological features of pachygyria–agyria complex. Superficial layer and thickened fourth layer demonstrate high anisotropy. Identification of anisotropy in the superficial layer has not been described in previous reports.

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Title: Demonstration of different histological layers of the pachygyria/agyria cortex using diffusion tensor MR imaging
Authors: Zarina A. Aziz
Jitender Saini
P. S. Bindu
G. G. Sharath Kumar
Publication date: 01-07-2013
Publisher: Springer-Verlag
Published in: Surgical and Radiologic Anatomy / Issue 5/2013
Print ISSN: 0930-1038
Electronic ISSN: 1279-8517
DOI: https://doi.org/10.1007/s00276-012-1050-8

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Demonstration of different histological layers of the pachygyria/agyria cortex using diffusion tensor MR imaging

Abstract

Purpose

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

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