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CardioVascular and Interventional Radiology
Published in: CardioVascular and Interventional Radiology 2/2017

01-02-2017 | Review

The Role of Interventional Oncology in the Management of Lung Cancer

Authors: Ejona Duka, Anna Maria Ierardi, Chiara Floridi, Alberto Terrana, Federico Fontana, Gianpaolo Carrafiello

Published in: CardioVascular and Interventional Radiology | Issue 2/2017

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Abstract

Interventional radiological procedures for diagnosis and treatment of lung cancer have become increasingly important. Imaging-guided percutaneous biopsy has become the modality of choice for diagnosing lung cancer, and in the era of target therapies, it is an useful tool to define earlier patient-specific tumor phenotypes. In functionally inoperable patients, especially the ablative procedures are potentially curative alternatives to surgery. In addition to thermally ablative treatment, selective chemoembolization by a vascular access allows localized therapy. These treatments are considered for patients in a reduced general condition which does not allow systemic chemotherapy. The present article reviews the role of interventional oncology in the management of primary lung cancer, focusing on the state of the art for each procedure.
Literature
1.
Stewart BW, Wild C. World Cancer Report. Lyon: International Agency for Research on Cancer; World Health Organization; 2014.
2.
Gangi A, Buy X. Imagerie interventionelle du cancer bronchique: du diagnostic ai traitement. Rev Mal Respir. 2007;24:6S137–45.CrossRefPubMed
3.
Priola AM, Priola SM, Cataldi A, et al. Accuracy of CT-guided transthoracic needle biopsy of lung lesions: factors affecting diagnostic yield. Radiol Med. 2007;112:1142–59.CrossRefPubMed
4.
5.
Fujita S, Mio T, Sonobe M, et al. Accuracy of epidermal growth factor receptor mutation analysis on the basis of small biopsy specimens in patients with nonsmall cell lung cancer. Int J Cancer. 2006;119:1751–2.CrossRefPubMed
6.
Hsieh MH, Fang YF, Chang WC, et al. Complex mutation patterns of epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in patients with non-small cell lung cancer. Lung Cancer. 2006;53:311–22.CrossRefPubMed
7.
Solomon SB, Zakowski MF, Pao W, et al. Core needle lung biopsy specimens: adequacy for EGFR and KRAS mutational analysis. AJR Am J Roentgenol. 2010;194:266–9.CrossRefPubMedPubMedCentral
8.
Yoon HJ, Lee HY, Lee KS, et al. Repeat biopsy for mutational analysis of non-small cell lung cancers resistant to previous chemotherapy: adequacy and complications. Radiology. 2012;265:939–48.CrossRefPubMed
9.
Rotolo N, Floridi C, Imperatori A, et al. Comparison of cone-beam CT-guided and CT fluoroscopy-guided transthoracic needle biopsy of lung nodules. Eur Radiol. 2016;26:381–9.CrossRefPubMed
10.
O’Neill AC, McCarthy C, Ridge CA, et al. Rapid needle-out patient-rollover time after percutaneous CT-guided transthoracic biopsy of lung nodules: effect on pneumothorax rate. Radiology. 2012;262(1):314–9.CrossRefPubMed
11.
Kim JI, Park CM, Lee SM, et al. Rapid needle-out patient-rollover approach after cone beam CT-guided lung biopsy: effect on pneumothorax rate in 1,191 consecutive patients. Eur Radiol. 2015;25:1845–53.CrossRefPubMed
12.
Dendo S, Kanazawa S, Ando A, et al. Preoperative localization of small pulmonary lesions with a short hook wire and suture system: experience with 168 procedures. Radiology. 2002;225(2):511–8.CrossRefPubMed
13.
Pereira PL, Masala S. Cardiovascular and Interventional Radiological Society of Europe (CIRSE). Standards of practice: guidelines for thermal ablation of primary and secondary lung tumors. Cardiovasc Intervent Radiol. 2012;35(2):247–54.CrossRefPubMed
14.
15.
Goldberg SN, Gazelle GS, Compton CC, et al. Radiofrequency tissue ablation in the rabbit lung: efficacy and complications. Acad Radiol. 1995;2:776–84.CrossRefPubMed
16.
Dupuy DE, Zagoria RJ, Akerley W, et al. Percutaneous radiofrequency ablation of malignancies in the lung. AJR Am J Roentgenol. 2000;174:57–9.CrossRefPubMed
17.
Nahum Goldberg S, Dupuy DE. Image-guided radiofrequency tumor ablation: challenges and opportunities—part I. J Vasc Interv Radiol. 2001;12:1021–32.CrossRefPubMed
18.
Vogl TJ, Naguib NN, Lehnert T, et al. Radiofrequency, microwave and laser ablation of pulmonary neoplasms: clinical studies and technical considerations—Review article. Eur J Radiol. 2011;77:346–57.CrossRefPubMed
19.
Zhu JC, Yan TD, Morris DL. A systematic review of radiofrequency ablation for lung tumors. Ann Surg Oncol. 2008;15:1765–74.CrossRefPubMed
20.
Kim SR, Han HJ, Park SJ, et al. Comparison between surgery and radiofrequency ablation for stage I non-small cell lung cancer. Eur J Radiol. 2011;81:395–9.CrossRefPubMed
21.
Zemlyak A, Moore WH, Bilfinger TV. Comparison of survival after sublobar resections and ablative therapies for stage I non-small cell lung cancer. J Am Coll Surg. 2010;211:68–72.CrossRefPubMed
22.
Safi S, Rauch G, op den Winkel J, et al. Sublobar resection, radiofrequency ablation or radiotherapy in stage I non-small cell lung cancer. Respiration. 2015;89:550–7.CrossRefPubMed
23.
Dupuy DE, Fernando HC, Hillman S, et al. Radiofrequency ablation of stage IA non-small cell lung cancer in medically inoperable patients: results from the American College of Surgeons Oncology Group Z4033 (Alliance) trial. Cancer. 2015;121:3491–8.CrossRefPubMedPubMedCentral
24.
25.
Ridge CA, Silk M, Petre EN, et al. Radiofrequency ablation of T1 lung carcinoma: comparison of outcomes for first primary, metachronous, and synchronous lung tumors. J Vasc Interv Radiol. 2014;25:989–96.CrossRefPubMed
26.
Kodama H, Yamakado K, Hasegawa T, et al. Radiofrequency ablation using a multiple-electrode switching system for lung tumors with 2.0–5.0-cm maximum diameter: phase II clinical study. Radiology. 2015;277:895–902.CrossRefPubMed
27.
Simon CJ, Dupuy DE, DiPetrillo TA, et al. Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients. Radiology. 2007;243:268–75.CrossRefPubMed
28.
Palussiere J, Lagarde P, Auperin A, et al. Percutaneous lung thermal ablation of non-surgical clinical N0 non-small cell lung cancer: results of eight years’ experience in 87 patients from two centers. Cardiovasc Intervent Radiol. 2015;38:160–6.CrossRefPubMed
29.
Hiraki T, Gobara H, Mimura H, et al. Percutaneous radiofrequency ablation of clinical stage I non-small cell lung cancer. J Thorac Cardiovasc Surg. 2011;142:24–30.CrossRefPubMed
30.
Huang L, Han Y, Zhao J, et al. Is radiofrequency thermal ablation a safe and effective procedure in the treatment of pulmonary malignancies? Eur J Cardiothorac Surg. 2011;39:348–51.CrossRefPubMed
31.
Ambrogi MC, Fanucchi O, Cioni R, et al. Long-term results of radiofrequency ablation treatment of stage I non-small cell lung cancer: a prospective intention-to-treat study. J Thorac Oncol. 2011;6(12):2044–51.CrossRefPubMed
32.
Lanuti M, Sharma A, Willers H, et al. Radiofrequency ablation for stage I non-small cell lung cancer: management of locoregional recurrence. Ann Thorac Surg. 2012;93:921–7.CrossRefPubMed
33.
Lencioni R, Crocetti L, Cioni R, et al. Response to radiofrequency ablation of pulmonary tumours: a prospective, intention intention-to-treat, multicentre clinical trial (the RAPTURE study). Lancet Oncol. 2008;9:621–8.CrossRefPubMed
34.
Liu B, Liu L, Hu M, et al. vPercutaneous radiofrequency ablation for medically inoperable patients with clinical stage I non-small cell lung cancer. Thorac Cancer. 2015;6:327–33.CrossRefPubMed
35.
Carrafiello G, Mangini M, Fontana F, et al. Radiofrequency ablation for single lung tumours not suitable for surgery: seven years’ experience. Radiol Med. 2012;117:1320–32.CrossRefPubMed
36.
Carrafiello G, Mangini M, De Bernardi I, et al. Microwave ablation therapy for treating primary and secondary lung tumours: technical note. Radiol Med. 2010;115:962–74.CrossRefPubMed
37.
Wolf FJ, Grand DJ, Machan JT, et al. Microwave ablation of lung malignancies: effectiveness, CT findings, and safety in 50 patients. Radiology. 2008;247:871–9.CrossRefPubMed
38.
Lu Q, Cao W, Huang L, Wan Y, et al. CT-guided percutaneous microwave ablation of pulmonary malignancies: results in 69 cases. World J Surg Oncol. 2012;7(10):80.CrossRef
39.
Belfiore G, Ronza F, Belfiore MP, et al. Patients’ survival in lung malignancies treated by microwave ablation: our experience on 56 patients. Eur J Radiol. 2013;82:177–81.CrossRefPubMed
40.
Liu H, Steinke K. High-powered percutaneous microwave ablation of stage I medically non-small cell lung cancer: a preliminary study. J Med Imaging Radiat Oncol. 2013;57:466–744.CrossRefPubMed
41.
Yang X, Ye X, Zheng A, et al. Percutaneous microwave ablation of stage I medically inoperable non-small cell lung cancer: clinical evaluation of 47 cases. J Surg Oncol. 2014;110:758–63.CrossRefPubMedPubMedCentral
42.
Wei Z, Ye X, Yang X, et al. Microwave ablation plus chemotherapy improved progression-free survival of advanced non-small cell lung cancer compared to chemotherapy alone. Med Oncol. 2015;32:464.CrossRefPubMed
43.
Wei Z, Ye X, Yang X, et al. Microwave ablation in combination with chemotherapy for the treatment of advanced non-small cell lung cancer. Cardiovasc Intervent Radiol. 2015;38:135–42.CrossRefPubMed
44.
Xu X, Ye X, Liu G, et al. Targeted percutaneous microwave ablation at the pulmonary lesion combined with mediastinal radiotherapy with or without concurrent chemotherapy in locally advanced non-small cell lung cancer evaluation in a randomized comparison study. Med Oncol. 2015;32:227.CrossRefPubMed
45.
Carrafiello G, Mangini M, Fontana F, et al. Microwave ablation of lung tumours: single-centre preliminary experience. Radiol Med. 2014;119:75–82.CrossRefPubMed
46.
47.
Hinshaw JL, Lee FT Jr, Laeseke PF, et al. Temperature isotherms during pulmonary cryoablation and their correlation with the zone of ablation. J Vasc Intervent Radiol. 2010;21:1424–8.CrossRef
48.
Hinshaw JL, Littrup PJ, Durick N, et al. Optimizing the protocol for pulmonary cryoablation: a comparison of a dual- and triple- freeze protocol. Cardiovasc Intervent Radiol. 2010;33:1180–5.CrossRefPubMedPubMedCentral
49.
Inoue M, Nakatsuka S, Jinzaki M. Cryoablation of early-stage primary lung cancer. Biomed Res Int. 2014;2014:52–1691.CrossRef
50.
Yamauchi Y, Izumi Y, Hashimoto K, et al. Percutaneous cryoablation for the treatment of medically inoperable stage I non-small cell lung cancer. PLoS ONE. 2012;7:e33223.CrossRefPubMedPubMedCentral
51.
Zhang X, Tian J, Zhao L, et al. CT-guided conformal cryoablation for peripheral NSCLC: initial experience. Eur J Radiol. 2012;81:3354–62.CrossRefPubMed
52.
Pusceddu C, Sotgia B, Fele RM et al (2013) CT-guided thin needles percutaneous cryoablation (PCA) in patients with primary and secondary lung tumors: a preliminary experience. Eur J Radiol 82:246–e253.
53.
Yashiro H, Nakatsuka S, Inoue M, et al. Factors affecting local progression after percutaneous cryoablation of lung tumors. J Vasc Intervent Radiol. 2013;24:813–21.CrossRef
54.
Golder WA. Chemoembolization of the lungs: basic anatomical elements, experimental results, clinical experience. Onkologe. 2008;14:934–9.CrossRef
55.
56.
Walker CM, Rosado-de-Christenson ML, Martínez-Jiménez S, et al. Bronchial arteries: anatomy, function, hypertrophy, and anomalies. Radiographics. 2015;35:32–49.CrossRefPubMed
57.
Vogl TJ, Shafinaderi M, Zangos S, et al. Regional chemotherapy of the lung: transpulmonary chemoembolization in malignant lung tumors. Semin Intervent Radiol. 2013;30:176–84.CrossRefPubMedPubMedCentral
58.
Franke UF, Wittwer T, Lessel M, et al. Evaluation of isolated lung perfusion as neoadjuvant therapy of lung metastases using a novel in vivo pig model: i. Influence of perfusion pressure and hyperthermia on functional and morphological lung integrity. Eur J Cardiothorac Surg. 2004;26:792–9.CrossRefPubMed
59.
Schneider P, Kampfer S, Loddenkemper C, et al. Chemoembolization of the lung improves tumor control in a rat model. Clin Cancer Res. 2002;8:2463–8.PubMed
60.
Lindemayr S, Lehnert T, Korkusuz H, et al. Transpulmonary chemoembolization: a novel approach for the treatment of unresectable lung tumors. Tech Vasc Intervent Rad. 2007;10:114–9.CrossRef
61.
Baylatry MT, Pelage JP, Wassef M, et al. Pulmonary artery chemoembolization in a sheep model: evaluation of performance and safety of irinotecan eluting beads (DEB-IRI). J Biomed Mater Res B Appl Biomater. 2011;98:351–9.CrossRefPubMed
62.
Park HS, Kim YI, Kim HY, et al. Bronchial artery and systemic artery embolization in the management of primary lung cancer patients with hemoptysis. Cardiovasc Intervent Radiol. 2007;30:638–43.CrossRefPubMed
63.
Garcia-Olivé I, Sanz-Santos J, Centeno C, et al. Results of bronchial artery embolization for the treatment of hemoptysis caused by neoplasm. J Vasc Interv Radiol. 2014;25:221–8.CrossRefPubMed
64.
Prévost JB, Nuyttens JJ, Hoogeman MS, et al. Endovascular coils as lung tumour markers in real-time tumour tracking stereotactic radiotherapy: preliminary results. Eur Radiol. 2008;18:1569–76.CrossRefPubMedPubMedCentral
65.
Karaman K, Dokdok AM, Karadeniz O, et al. Intravascular placement of metallic coils as lung tumor markers for cyberknife stereotactic radiation therapy. Korean J Radiol. 2015;16:626–31.CrossRefPubMedPubMedCentral
66.
Mallick R, Demmy T. Regional lung chemotherapy techniques. Innovations (Phila). 2011;6:1–9.CrossRef
67.
Nakanishi M, Demura Y, Umeda Y, et al. Multi-arterial infusion chemotherapy for non-small cell lung carcinoma–significance of detecting feeding arteries and tumor staining. Lung Cancer. 2008;61:227–34.CrossRefPubMed
68.
Demmy TL, Tomaszewski G, Dy GK, et al. Thoracoscopic organ suffusion for regional lung chemotherapy (preliminary results). Ann Thorac Surg. 2009;88:385–90.CrossRefPubMed
69.
Ferris EJ. Pulmonary hemorrhage. Vascular evaluation and interventional therapy. Chest. 1981;80:710–4.CrossRefPubMed
70.
Chun JY, Morgan R, Belli AM, et al. Radiological management of hemoptysis: a comprehensive review of diagnostic imaging and bronchial arterial embolization. Cardiovasc Intervent Radiol. 2010;33:240–50.CrossRefPubMed
71.
Hahn S, Kim YJ, Kwon W, et al. Comparison of the effectiveness of embolic agents for bronchial artery embolization: gelfoam versus polyvinyl alcohol. Korean J Radiol. 2010;11:542–6.CrossRefPubMedPubMedCentral
72.
Yoon W, Kim JK, Kim YH, et al. Bronchial and nonbronchial systemic artery embolization for life-threatening hemoptysis: a comprehensive review. Radiographics. 2002;22:1395–409.CrossRefPubMed
73.
Baltacioglu F, Cimsit NC, Bostanci K, et al. Transarterial microcatheter glue embolization of the bronchial artery for life-threatening hemoptysis: technical and clinical results. Eur J Radiol. 2010;73:380–4.CrossRefPubMed
74.
Razavi MK, Murphy K. Embolization of bronchial arteries with N-butyl cyanoacrylate for management of massive hemoptysis: a technical review. Tech Vasc Interv Radiol. 2007;10:276–82.CrossRefPubMed
75.
Woo S, Yoon CJ, Chung JW, et al. Bronchial artery embolization to control hemoptysis: comparison of N-butyl-2-cyanoacrylate and polyvinyl alcohol particles. Radiology. 2013;269:594–602.CrossRefPubMed
76.
Andersen PE. Imaging and interventional radiological treatment of hemoptysis. Acta Radiol. 2006;47:780–92.CrossRefPubMed
77.
Ittrich H, Klose H, Adam G. Radiologic management of haemoptysis: diagnostic and interventional bronchial arterial embolisation. Fortschr Röntgenstr. 2015;187:248–59.CrossRef
78.
Nakanishi M, Umeda Y, Demura Y, et al. Effective use of multi-arterial infusion chemotherapy for advanced non-small cell lung cancer patients: four clinical specified cases. Lung Cancer. 2007;55:241–7.CrossRefPubMed
79.
Nakanishi M, Yoshida Y, Natazuka T. Prospective study of transarterial infusion of docetaxel and cisplatin to treat non-small-cell lung cancer in patients contraindicated for standard chemotherapy. Lung Cancer. 2012;77:353–8.CrossRefPubMed
80.
Yuan Z, Li WT, Ye XD, et al. Intra-arterial infusion chemotherapy for advanced non-small-cell lung cancer: preliminary experience on the safety, efficacy, and clinical outcomes. J Vasc Interv Radiol. 2013;24(1521–8):e4.
81.
82.
Fagedet D, Thony F, Timsit JF, et al. Endovascular treatment of malignant superior vena cava syndrome: results and predictive factors of clinical efficacy. Cardiovasc Intervent Radiol. 2013;36:140–9.CrossRefPubMed
83.
Lanciego C, Pangua C, Chacón JI, et al. Endovascular stenting as the first step in the overall management of malignant superior vena cava syndrome. AJR Am J Roentgenol. 2009;193:549–58.CrossRefPubMed
84.
Uberoi R. Quality assurance guidelines for superior vena cava stenting in malignant disease. Cardiovasc Intervent Radiol. 2006;29:319–22.CrossRefPubMed
85.
Bierdrager E, Lampmann LEH, Lohle PNM, et al. Endovascular stenting in neoplastic superior vena cava syndrome prior to chemotherapy or radiotherapy. Neth J Med. 2005;63:20–3.PubMed
86.
Nagata T, Makutani S, Uchida H, et al. Follow-up results of 71 patients undergoing metallic stent placement for the treatment of a malignant obstruction of the superior vena cava. Cardiovasc Intervent Radiol. 2007;30:959–67.CrossRefPubMed
87.
Gwon DI, Ko GY, Kim JH, et al. Malignant superior vena cava syndrome: a comparative cohort study of treatment with covered stents versus uncovered stents. Radiology. 2013;266:979–87.CrossRefPubMed
88.
Maleux G, Gillardin P, Fieuws S, et al. Large-bore nitinol stents for malignant superior vena cava syndrome: factors influencing outcome. AJR Am J Roentgenol. 2013;201:667–74.CrossRefPubMed
89.
Sobrinho G, Aguiar P. Stent placement for the treatment of malignant superior vena cava syndrome—a single-center series of 56 patients. Arch Bronconeumol. 2014;50:135–40.CrossRefPubMed
90.
91.
Cho Y, Gwon DI, Ko GY, et al. Covered stent placement for the treatment of malignant superior vena cava syndrome: is unilateral covered stenting safe and effective? Korean J Radiol. 2014;15:87–94.CrossRefPubMedPubMedCentral
92.
Andersen PE, Midtgaard A, Brenöe AS, et al. A new nitinol stent for use in superior vena cava syndrome. Initial clinical experience. J Cardiovasc Surg. 2015;56:877–81.
93.
Mokry T, Bellemann N, Sommer CM, et al. Retrospective study in 23 patients of the self-expanding sinus-XL stent for treatment of malignant superior vena cava obstruction caused by non-small cell lung cancer. J Vasc Interv Radiol. 2015;26:357–65.CrossRefPubMed
94.
Gulati A, Shah R, Puttanniah V, et al. A retrospective review and treatment paradigm of interventional therapies for patients suffering from intractable thoracic chest wall pain in the oncologic population. Pain Med. 2015;16:802–10.CrossRefPubMed
95.
Wong FC, Lee TW, Yuen KK, et al. Intercostal nerve blockade for cancer pain: effectiveness and selection of patients. Hong Kong Med J. 2007;13:266–70.PubMed
Metadata
Title
The Role of Interventional Oncology in the Management of Lung Cancer
Authors
Ejona Duka
Anna Maria Ierardi
Chiara Floridi
Alberto Terrana
Federico Fontana
Gianpaolo Carrafiello
Publication date
01-02-2017
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 2/2017
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-016-1495-y

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