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CardioVascular and Interventional Radiology

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01-04-2014 | Clinical Investigation

Systematic Review and Meta-Analysis of Thermal Ablation Versus Surgical Nephrectomy for Small Renal Tumours

Authors: K. Katsanos, L. Mailli, M. Krokidis, A. McGrath, T. Sabharwal, A. Adam

Published in: CardioVascular and Interventional Radiology | Issue 2/2014

Abstract

Purpose

A systematic review was undertaken to provide a meta-analysis of clinical trials comparing thermal ablation with surgical nephrectomy for small renal tumours.

Methods

PubMed (MEDLINE), EMBASE, AMED, and Scopus were searched in August 2013 for eligible prospective or retrospective comparative trials following the PRISMA selection process. Thermal ablation was compared with surgical nephrectomy. Quality of included studies was assessed on the Newcastle-Ottawa Scale (NOS). The primary endpoint was disease-free survival and was analyzed on the log-hazard scale. Secondary outcome measures included complications, local recurrence, and decline of renal function. Hazard ratios (HR) and risk ratios (RR) were calculated with a random effects model, and meta-regression analysis was performed to explore clinical heterogeneity.

Results

Six clinical trials (1 randomized and 5 cohort; 6–8 stars on the NOS scale) involving 587 patients with small renal tumors (mean size 2.5 cm) treated with either thermal ablation (percutaneous or laparoscopic application of radiofrequency or microwave) or surgical nephrectomy (open or laparoscopic) were analyzed. Overall complication rate was significantly lower in the ablation group (7.4 vs. 11 %; RR: 0.55, 95 % confidence interval [CI]: 0.31–0.97, p = 0.04). Postoperative decline of eGFR was higher in case of nephrectomy (mean difference: −14.6 ml/min/1.73 m², 95 % CI: −27.96 to −1.23, p = 0.03). Local recurrence rate was the same in both groups (3.6 vs. 3.6 %; RR: 0.92, 95 % CI: 0.4–2.14, p = 0.79) and disease-free survival also was similar up to 5 years (HR: 1.04, 95 % CI: 0.48–2.24, p = 0.92).

Conclusions

Thermal ablation of small renal masses produces oncologic outcomes similar to surgical nephrectomy and is associated with significantly lower overall complication rates and a significantly less decline of renal function. More randomized, controlled trials are necessary.

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Title: Systematic Review and Meta-Analysis of Thermal Ablation Versus Surgical Nephrectomy for Small Renal Tumours
Authors: K. Katsanos
L. Mailli
M. Krokidis
A. McGrath
T. Sabharwal
A. Adam
Publication date: 01-04-2014
Publisher: Springer US
Published in: CardioVascular and Interventional Radiology / Issue 2/2014
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-014-0846-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Systematic Review and Meta-Analysis of Thermal Ablation Versus Surgical Nephrectomy for Small Renal Tumours

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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