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CardioVascular and Interventional Radiology

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01-06-2013 | CIRSE Standards of Practice Guidelines

Standards of Practice in Transarterial Radioembolization

Authors: Andreas H. Mahnken, Carlo Spreafico, Geert Maleux, Thomas Helmberger, Tobias F. Jakobs

Published in: CardioVascular and Interventional Radiology | Issue 3/2013

Excerpt

Primary cancer to the liver is the second most frequent cause of cancer death worldwide. There are 750,000 new cases of liver cancer worldwide [1], and metastatic liver disease is the most common cause of cancer death. Only about 25 % of patients with primary or secondary liver cancer are eligible for surgery, with a roughly 50 % 5-year overall survival in metastatic colorectal cancer (CRC) and little more than 20 months’ median overall survival with systemic chemotherapy alone [2]. Thus, interventional techniques evolved as a first-line treatment in primary liver tumors and are increasingly used in metastatic liver disease. Radiation-based approaches are appealing because they are known to be cytocidal in sufficient doses and they are independent from chemical or other energy-based treatment techniques. Although delivery of >70 Gy is thought to be needed to achieve solid tumor destruction [3], the tolerance of normal liver tissue is approximately 30 Gy [4]. These conditions resulted in the idea of selective transarterial radiation delivery and triggered the development of various transarterial radiation-based therapies, with ⁹⁰Y microspheres being the current mainstay of radioembolization (RE). …

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Title: Standards of Practice in Transarterial Radioembolization
Authors: Andreas H. Mahnken
Carlo Spreafico
Geert Maleux
Thomas Helmberger
Tobias F. Jakobs
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: CardioVascular and Interventional Radiology / Issue 3/2013
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-013-0600-8

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Standards of Practice in Transarterial Radioembolization

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