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Published in: CardioVascular and Interventional Radiology 6/2008

01-11-2008 | Technical Note

Continuous Intra-Arterial Nimodipine for the Treatment of Cerebral Vasospasm

Authors: Thomas E. Mayer, Martin Dichgans, Andreas Straube, Tobias Birnbaum, Stephanie Müller-Schunk, Gerhard F. Hamann, Gernot Schulte-Altedorneburg

Published in: CardioVascular and Interventional Radiology | Issue 6/2008

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Abstract

Two patients with refractory symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) were treated by continuous intra-arterial nimodipine infusion via a catheter placed in the internal carotid artery or vertebral artery for 3 and 12 days, respectively. Recovery of the neurological deficits, normalization of MR perfusion, a decrease in the elevated mean flow velocity measured by transcranial duplex sonography, and angiographic recanalization were observed. Continuous intra-arterial nimodipine might be a treatment option in severe refractory vasospasm following SAH.
Literature
1.
go back to reference Weir B, MacDonald L (1993) Cerebral vasospasm. Clin Neurosurg 40:40–45PubMed Weir B, MacDonald L (1993) Cerebral vasospasm. Clin Neurosurg 40:40–45PubMed
2.
go back to reference Rinkel G, Feigin V, Algra A, Bergh W, Vermeulen M, Gijn J (2005) Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev 25:CD000277 Rinkel G, Feigin V, Algra A, Bergh W, Vermeulen M, Gijn J (2005) Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev 25:CD000277
3.
go back to reference Meyer FB (1990) Calcium antagonists and vasospasm. Neurosurg Clin N Am 1:367–376PubMed Meyer FB (1990) Calcium antagonists and vasospasm. Neurosurg Clin N Am 1:367–376PubMed
4.
go back to reference Rosenwasser RH, Armonda RA, Thomas JE, Benitez RP, Gannon PM, Harrop J (1999) Therapeutic modalities for the management of cerebral vasospasm: timing of endovascular options. Neurosurgery 44:975–979PubMedCrossRef Rosenwasser RH, Armonda RA, Thomas JE, Benitez RP, Gannon PM, Harrop J (1999) Therapeutic modalities for the management of cerebral vasospasm: timing of endovascular options. Neurosurgery 44:975–979PubMedCrossRef
5.
go back to reference Terry A, Zipfel G, Milner E et al (2006) Safety and technical efficacy of over-the-wire balloons for the treatment of subarachnoid hemorrhage-induced cerebral vasospasm. Neurosurg Focus 21:E14PubMedCrossRef Terry A, Zipfel G, Milner E et al (2006) Safety and technical efficacy of over-the-wire balloons for the treatment of subarachnoid hemorrhage-induced cerebral vasospasm. Neurosurg Focus 21:E14PubMedCrossRef
6.
go back to reference Numaguchi Y, Zoarski GH, Clouston JE et al (1997) Repeat intra-arterial papaverine for recurrent cerebral vasospasm after subarachnoid haemorrhage. Neuroradiology 39:751–759PubMedCrossRef Numaguchi Y, Zoarski GH, Clouston JE et al (1997) Repeat intra-arterial papaverine for recurrent cerebral vasospasm after subarachnoid haemorrhage. Neuroradiology 39:751–759PubMedCrossRef
7.
go back to reference Liu JK, Tenner MS, Gottfried ON et al (2004) Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm. J Neurosurg 100:414–421PubMed Liu JK, Tenner MS, Gottfried ON et al (2004) Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm. J Neurosurg 100:414–421PubMed
8.
go back to reference Biondi A, Ricciardi GK, Puybasset L et al (2004) Intra-arterial nimodipine for the treatment of symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage: preliminary results. Am J Neuroradiol 25:1067–1076PubMed Biondi A, Ricciardi GK, Puybasset L et al (2004) Intra-arterial nimodipine for the treatment of symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage: preliminary results. Am J Neuroradiol 25:1067–1076PubMed
9.
go back to reference Hui C, Lau KP (2005) Efficacy of intra-arterial nimodipine in the treatment of cerebral vasospasm complicating subarachnoid haemorrhage. Clin Radiol 60:1030–1036PubMedCrossRef Hui C, Lau KP (2005) Efficacy of intra-arterial nimodipine in the treatment of cerebral vasospasm complicating subarachnoid haemorrhage. Clin Radiol 60:1030–1036PubMedCrossRef
10.
go back to reference Badjatia N, Topcuoglu MA, Pryor JC et al (2004) Preliminary experience with intra-arterial nicardipine as a treatment for cerebral vasospasm. Am J Neuroradiol 25:819–826PubMed Badjatia N, Topcuoglu MA, Pryor JC et al (2004) Preliminary experience with intra-arterial nicardipine as a treatment for cerebral vasospasm. Am J Neuroradiol 25:819–826PubMed
11.
go back to reference Feng L, Fitzsimmons BF, Young WL et al (2002) Intraarterially administered verapamil as adjunct therapy for cerebral vasospasm: safety and 2-year experience. Am J Neuroradiol 23:1284 –1290PubMed Feng L, Fitzsimmons BF, Young WL et al (2002) Intraarterially administered verapamil as adjunct therapy for cerebral vasospasm: safety and 2-year experience. Am J Neuroradiol 23:1284 –1290PubMed
12.
go back to reference Böker DK, Solymosi L, Wassmann H (1985) Immediate postangiographic intraarterial treatment of cerebral vasospasm after subarachnoid hemorrhage with nimodipine: report on 3 cases. Neurochirurgia 28:118–120PubMed Böker DK, Solymosi L, Wassmann H (1985) Immediate postangiographic intraarterial treatment of cerebral vasospasm after subarachnoid hemorrhage with nimodipine: report on 3 cases. Neurochirurgia 28:118–120PubMed
13.
go back to reference Grotenhuis JA, Bettag W, Fiebach BJ, Dabir K (1984) Intracarotid slow bolus injection of nimodipine during angiography for treatment of cerebral vasospasm after SAH: a preliminary report. J Neurosurg 61:231–240PubMedCrossRef Grotenhuis JA, Bettag W, Fiebach BJ, Dabir K (1984) Intracarotid slow bolus injection of nimodipine during angiography for treatment of cerebral vasospasm after SAH: a preliminary report. J Neurosurg 61:231–240PubMedCrossRef
14.
go back to reference Grotenhuis JA, Bettag W (1986) Prevention of symptomatic vasospasm after SAH by constant venous infusion of nimodipine. Neurol Res 8:243–249PubMedCrossRef Grotenhuis JA, Bettag W (1986) Prevention of symptomatic vasospasm after SAH by constant venous infusion of nimodipine. Neurol Res 8:243–249PubMedCrossRef
15.
go back to reference Zygmunt SC, Delgado-Zygmunt TJ (1995) The haemodynamic effect of transcranial Doppler-guided high-dose nimodipine treatment in established vasospasm after subarachnoid hemorrhage. Acta Neurochir 135:179–185CrossRef Zygmunt SC, Delgado-Zygmunt TJ (1995) The haemodynamic effect of transcranial Doppler-guided high-dose nimodipine treatment in established vasospasm after subarachnoid hemorrhage. Acta Neurochir 135:179–185CrossRef
16.
go back to reference Suzuki S, Ito O, Sayama T, Yamaguchi S, Goto K, Sasaki T (2006) Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: preliminary report of two cases. Neuroradiology 48:50–53PubMedCrossRef Suzuki S, Ito O, Sayama T, Yamaguchi S, Goto K, Sasaki T (2006) Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: preliminary report of two cases. Neuroradiology 48:50–53PubMedCrossRef
17.
go back to reference Qureshi AI, Luft AR, Sharma M, Guterman LR, Hopkins LN (2000) Prevention and treatment of thromboembolic and ischemic complications associated with endovascular procedures: part II. Clinical aspects and recommendations. Neurosurgery 46:1360–1375PubMedCrossRef Qureshi AI, Luft AR, Sharma M, Guterman LR, Hopkins LN (2000) Prevention and treatment of thromboembolic and ischemic complications associated with endovascular procedures: part II. Clinical aspects and recommendations. Neurosurgery 46:1360–1375PubMedCrossRef
18.
go back to reference Barth M, Capelle HH, Weidauer S et al (2007) Effect of nicardipine prolonged-release implants on cerebral vasospasm and outcome after severe aneurysmal subarachnoid hemorrhage. A prospective, randomized, double-blind phase IIa clinical study. Stroke 38:330–336PubMedCrossRef Barth M, Capelle HH, Weidauer S et al (2007) Effect of nicardipine prolonged-release implants on cerebral vasospasm and outcome after severe aneurysmal subarachnoid hemorrhage. A prospective, randomized, double-blind phase IIa clinical study. Stroke 38:330–336PubMedCrossRef
19.
go back to reference Vajkoczy P, Meyer B, Weidauer S et al (2005) Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter Phase IIa study. J Neurosurg 103:9–17PubMed Vajkoczy P, Meyer B, Weidauer S et al (2005) Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter Phase IIa study. J Neurosurg 103:9–17PubMed
Metadata
Title
Continuous Intra-Arterial Nimodipine for the Treatment of Cerebral Vasospasm
Authors
Thomas E. Mayer
Martin Dichgans
Andreas Straube
Tobias Birnbaum
Stephanie Müller-Schunk
Gerhard F. Hamann
Gernot Schulte-Altedorneburg
Publication date
01-11-2008
Publisher
Springer-Verlag
Published in
CardioVascular and Interventional Radiology / Issue 6/2008
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-008-9346-0

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