Top

CardioVascular and Interventional Radiology

Published in:

01-09-2004

Gigantic Cavernous Hemangioma of the Liver Treated by Intra-Arterial Embolization with Pingyangmycin-Lipiodol Emulsion: A Multi-Center Study

Authors: Qingle Zeng, Yanhao Li, Yong Chen, Yong Ouyang, Xiang He, Heping Zhang

Published in: CardioVascular and Interventional Radiology | Issue 5/2004

Abstract

Purpose: To evaluate the therapeutic effect and safety of pingyangmycin-lipiodol emulsion (PLE) intra-arterial embolization for treating gigantic cavernous hemangioma of the liver (CHL).

Methods: Three hospitals (Nanfang Hospital, Inner Mongolia Autonomous Region’s Hospital and Huai He Hospital) participated in the study during 1997–2001. A total of 98 patients with CHL were embolized with PLE via the hepatic artery. The therapeutic effects including changes in tumor diameter, symptomatic improvement and occurrence of complications were evaluated for a period of 12 months after the procedure.

Results: The tumor diameters decreased significantly from 9.7 ± 2.3 cm to 5.6 ± 1.6 cm 6 months after the treatment (P < 0.01), and then to 3.0 ± 1.2 cm at 12 months (P < 0.01). Transient impairment of liver function was found in 77 cases after embolization, 69 cases of which returned to normal in 2 weeks, and the other eight cases of which recovered 1 month later. The clinical symptoms were significantly relieved in all 53 symptomatic patients. Persistent pain in the hepatic region was found in two cases, and these two patients resorted to surgery eventually.

Conclusion: Intra-arterial PLE embolization proves to be effective and safe in treating patients with CHL.

Graanov, AM, Tarazov, PG, Polysalov, VN 1994Arterial embolization in treatment of hepatic cavernous hemangiomaKhirurgiia (Mosk)41317

Jesic, R, Radojkovic, S, Tomic, D, Krstic, M, Jankovic, G, Milinic, N, Pavlovic, A, Crnobaric, M, Cvejic, T, Aleksic, T 1998Personal experience in embolization of liver hemangiomasSrp-Arh-Cvejic-Lek126349354

Althaus, S, Ashdown, B, Coldwell, D, Helton, WS, Freeny, PC 1996Transcatheter arterial embolization of two symptomatic giant cavernous hemangiomas of the liverCardiovasc Intervent Radiol19364367CrossRefPubMed

Zhao, ZR, Li, GW, Wang, GT, Li, Ruiming, Yang, Zengshang, Dai, Shejiao, Peng, Yuping 1994Investigation on blood supply and embolization treatment of cavernous hemangioma of the liverChin J Radiol28472475

Zhong, GH, Ma, Q, Zhou, ZR, Fengzhi, Xu 2000Inner hemangioma ligation and pingyangmycin injection of hemangioma (with 30 cases report)Chin J Plast Surg16133135

Zheng, Qintian, Li, Gongcai, Gu, Jianzhang, Zhang, Xiansheng, Chen, Jindian 1990The histological and ultrastructure study of hemangiomaChin J Pediatr Surg1178

Li, Linsun 1994Clinical interventional therapeuticsJiangsu Science and Technology Publishing CompanyNanjing86

Bhattacharya, S, Dhillon, AP, Winslet, MC, Davidson, BR, Shukla, N, Gupta, SD, Al-Mufti, R, Hobbs, KE 1996Human liver cancer cells and endothelial cells incorporate iodised oilB J Cancer73877881

Ouyang, Y, Ouyang, XH, Yu, M, Gu, SB 2001Frequency of arteriovenous shunts in hepatic cavernous hemangiomas in adults as seen on selective arteriography and postembolization radiographyCardiovasc Intervent Radiol24161167CrossRefPubMed

10.

Matalon, S, Harper, WV, Goldinger, JM, Nickerson, PA, Olszowka, J 1985Modification of pulmonary oxygen toxicity by bleomycin treatmentJ Appl Physiol5818021809PubMed

11.

Hay, JG, Haslam, PL, Dewar, A, Addis, B, Tumer-Warwick, M, Laurent, GJ 1987The development of acute lung injury following the combination of intravenous bleomycin and exposure to hyperoxia in ratsThorax42374382PubMed

12.

Jin, Hong, Tian, Qinglin, Yao, Hande, Yang, Jianjun, Cai, Shaohua, Yu, Guo, Tian, Yapping, Wu, Dezheng 1992A preliminary approach to pathological and biochemical changes of the lungs injured by domestic pingyangmycinChin J Pathol2178280

13.

Zeng, QL, Li, YH, Chen, Y, Xiaoli, Xu, Enjie, Lu, Jiangyu, Wang 2000The experimental study of intra-arterial infusion of pingyangmycin-lipiodol emulsion in rabbitsJ Clin Radiol19376379

14.

Zeng, QL, Li, YH, Chen, Y, Xu, Xiaoli, Wang, Tianyu 2000Clinical application of pingyangmycin-lipiodol emulsion embolization to treat cavernous hemangioma of liverChin J Radiol208689

Title: Gigantic Cavernous Hemangioma of the Liver Treated by Intra-Arterial Embolization with Pingyangmycin-Lipiodol Emulsion: A Multi-Center Study
Authors: Qingle Zeng
Yanhao Li
Yong Chen
Yong Ouyang
Xiang He
Heping Zhang
Publication date: 01-09-2004
Publisher: Springer-Verlag
Published in: CardioVascular and Interventional Radiology / Issue 5/2004
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-003-2754-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gigantic Cavernous Hemangioma of the Liver Treated by Intra-Arterial Embolization with Pingyangmycin-Lipiodol Emulsion: A Multi-Center Study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 5/2004

Heparin-Coated Angiographic Catheters: An In Vivo Comparison of Three Coating Methods with Different Heparin Release Profiles

Dual Balloon-Occluded Retrograde Transvenous Obliteration of Gastric Varix Draining into the Left Adrenal Vein and Left Inferior Phrenic Vein

Superselective Embolization in Posttraumatic Priapism with Glubran 2 Acrylic Glue

Percutaneous Endovascular Treatment of Chronic Iliac Artery Occlusion

Renal Angioplasty in Non-atheromatous Renal Artery Stenosis: Technical Results and Clinical Outcome in 43 Patients

Comparison of Echo and MRI in the Imaging Evaluation of Intracardiac Masses