Published in:
01-04-2003 | Clinical Investigations
Transcatheter Arterial Chemoembolization of Liver Tumors: Effects of Embolization Protocol on Injectable Volume of Chemotherapy and Subsequent Arterial Patency
Published in: CardioVascular and Interventional Radiology | Issue 2/2003
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The purpose of this study was to determine whether
transcatheter arterial chemoembolization (TACE) protocol affects the
total volume of chemotherapy injected into the liver as well as
subsequent arterial patency. A total of 160 patients with primary or
secondary liver cancer were treated with 3 different chemoembolization
protocols at a single institution. Data were analyzed retrospectively.
Group 1 (n = 36) consisted of slurry of chemotherapy,
oil and polyvinyl alcohol particles (PVA), group 2 (n =
91), chemotherapy and oil followed by PVA, and group 3
(n = 33), chemotherapy and oil followed by Gelfoam
pledgets. The total volume of chemotherapy injected into the liver was
recorded. Arterial patency was determined during subsequent
chemoembolizations. The mean percentage of total intended chemotherapy
dose administered was 54.6% for group 1, 75.3% for group 2, and
80.6% for group 3. Arterial patency at follow-up angiography was 56%
for group 1, 74% for group 2, and 81% for group 3. The slurry
protocol (group 1) significantly reduced arterial patency and
injectable volume of chemotherapy during TACE.