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World Journal of Surgery

Published in:

01-04-2012

Pancreatectomy Combined with Superior Mesenteric Vein–Portal Vein Resection for Pancreatic Cancer: A Meta-analysis

Authors: Yanming Zhou, Zhiming Zhang, Yujian Liu, Bin Li, Donghui Xu

Published in: World Journal of Surgery | Issue 4/2012

Abstract

Background

Pancreatectomy combined with superior mesenteric vein–portal vein resection (VR) for pancreatic cancer remains a matter of debate. The present study is a meta-analysis of the available evidence.

Methods

Articles published until end of March 2011, comparing the results of pancreatic resections with VR versus without VR, were searched. Pooled odds ratios (OR) and weighted mean differences (WMD; with 95% Confidence Intervals [95% CI]) were calculated using either the fixed effects model or the random effects model.

Results

Nineteen nonrandomized studies met the inclusion criteria, comprising 2,247 patients. There was no difference in perioperative morbidity (OR: 0.95; 95% CI: 0.74–1.21; P = 0.67), mortality (OR: 1.19; 95% CI: 0.73–1.96; P = 0.48), or 5-year overall survival (OR: 0.57; 95% CI: 0.32–1.02; P = 0.06) between patients with VR and those without VR.

Conclusions

Pancreatectomy combined with VR resection for pancreatic cancer is justified because it can result in good perioperative outcome and long-term survival comparable to that obtained with standard resection. Owing to the selection bias and low level of clinical evidence available so far, the results should be interpreted with caution.

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Title: Pancreatectomy Combined with Superior Mesenteric Vein–Portal Vein Resection for Pancreatic Cancer: A Meta-analysis
Authors: Yanming Zhou
Zhiming Zhang
Yujian Liu
Bin Li
Donghui Xu
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 4/2012
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-012-1461-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pancreatectomy Combined with Superior Mesenteric Vein–Portal Vein Resection for Pancreatic Cancer: A Meta-analysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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