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World Journal of Surgery

Published in:

01-01-2012

Risk Factors and Outcome of Intra-abdominal Hypertension in Patients with Severe Acute Pancreatitis

Authors: Lu Ke, Hai-bin Ni, Jia-kui Sun, Zhi-hui Tong, Wei-qin Li, Ning Li, Jie-shou Li

Published in: World Journal of Surgery | Issue 1/2012

Abstract

Background

Intra-abdominal hypertension (IAH) is common in patients with severe acute pancreatitis (SAP). The aim of the present study was to investigate the risk factors of IAH in SAP patients and assess the prognosis of SAP combined with IAH.

Methods

To analyze the data from patients with SAP, both univariate and multivariate logistic regression analyses were applied, using 16 indices, including age, gender, Acute Physiology and Chronic Health Evaluation II scores (APACHE II), 24 h fluid balance, hematocrit, serum calcium level, and so on. Clinical prognosis such as mortality, hospital duration, of SAP patients with or without IAH was also compared.

Results

First 24 h fluid balance (Odds Ratio [OR], 1.003; 95% Confidence Interval [CI], 1.001–1.006), number of fluid collections (OR, 1.652; 95% CI, 1.023–2.956), and serum calcium level (OR, 0.132; 95% CI, 0.012–0.775) were found to be independent risk factors for IAH in patients with SAP. Moreover, patients with SAP and IAH had significantly longer average length of stay, both in the hospital and in the intensive care unit, higher rates of systemic and local complications, and more invasive treatments.

Conclusions

The significant risk factors for IAH in patients with SAP include 24 h fluid balance (first day), number of fluid collections, and serum calcium level. Additionally, IAH is associated with extremely poor prognosis, evidenced by high rates of mortality, morbidity, and the need for invasive interventions.

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Title: Risk Factors and Outcome of Intra-abdominal Hypertension in Patients with Severe Acute Pancreatitis
Authors: Lu Ke
Hai-bin Ni
Jia-kui Sun
Zhi-hui Tong
Wei-qin Li
Ning Li
Jie-shou Li
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 1/2012
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-011-1295-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Risk Factors and Outcome of Intra-abdominal Hypertension in Patients with Severe Acute Pancreatitis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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